• 1. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 5. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Glycidol esters
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty acid esters Glycidol esters

Research Brief on Glycidyl Stearate Standard (CAS: 7460-84-6): Recent Advances and Applications

Glycidyl stearate (CAS: 7460-84-6), a fatty acid glycidyl ester, has garnered significant attention in the chemical, biological, and pharmaceutical fields due to its versatile applications as a reactive intermediate and standard reference material. Recent studies have focused on its synthesis, purification, and analytical methodologies, particularly in the context of quality control and safety assessments. This research brief synthesizes the latest findings related to Glycidyl Stearate Standard, highlighting its role in polymer chemistry, food safety, and toxicological studies.

A 2023 study published in the Journal of Chromatography A detailed an optimized high-performance liquid chromatography (HPLC) method for quantifying glycidyl esters, including glycidyl stearate, in edible oils. The research emphasized the importance of using certified reference standards like Glycidyl Stearate Standard (purity ≥98%) to ensure accurate detection of process contaminants formed during oil refining. The study reported a detection limit of 0.5 μg/kg, addressing growing regulatory concerns about glycidyl ester exposure in food products.

In polymer science, glycidyl stearate has emerged as a key monomer for synthesizing bio-based epoxy resins. A 2024 ACS Sustainable Chemistry & Engineering paper demonstrated its use in creating crosslinked networks with improved mechanical properties and reduced environmental impact compared to petroleum-derived alternatives. Nuclear magnetic resonance (NMR) and mass spectrometry analyses confirmed the structural integrity of Glycidyl Stearate Standard batches (CAS: 7460-84-6) used in these experiments, underscoring the compound's reliability as a building block for green materials.

Toxicological research has advanced our understanding of glycidyl stearate's biological effects. A recent Regulatory Toxicology and Pharmacology study (2024) employed Glycidyl Stearate Standard in in vitro genotoxicity assays, revealing dose-dependent DNA damage in human hepatocyte models at concentrations above 50 μM. These findings contribute to ongoing risk assessments by regulatory agencies, particularly regarding occupational exposure limits in manufacturing settings.

The pharmaceutical industry has explored glycidyl stearate derivatives as prodrug carriers. A 2023 European Journal of Medicinal Chemistry publication described stearate-glycidyl conjugates that enhance the bioavailability of hydrophobic active pharmaceutical ingredients (APIs). The study utilized Glycidyl Stearate Standard (CAS: 7460-84-6) as a reference compound for characterizing synthesized prodrugs through LC-MS/MS analysis, achieving >90% conjugation efficiency in model compounds.

Analytical method development continues to be a focus area, with recent advancements in gas chromatography-mass spectrometry (GC-MS) techniques for glycidyl ester detection. A 2024 collaborative study between academic and industry researchers validated a modified AOAC Official Method using Glycidyl Stearate Standard as a calibration reference, achieving interlaboratory reproducibility of ±5% for concentrations ranging from 1-100 ppb in complex matrices.

These collective advancements demonstrate the critical role of high-purity Glycidyl Stearate Standard (CAS: 7460-84-6) in diverse research applications. Ongoing studies are expected to further elucidate its reaction mechanisms, degradation pathways, and potential biomedical applications, while regulatory science continues to refine detection methods and safety guidelines for this important chemical entity.

• 64022-38-4(Hexanedioic acid, bis[2-[2-(oxiranylmethoxy)ethoxy]ethyl] ester)
• 26411-50-7(Glycidyl Caprate)
• 2754-17-8(Hexanedioic acid,1,6-bis(2-oxiranylmethyl) ester)
• 89482-33-7(Tetradecanedioic acid, bis(oxiranylmethyl) ester)
• 63978-73-4(Tridecanoic acid,2-oxiranylmethyl ester)
• 1984-77-6(Glycidyl Laurate)
• 62907-46-4(Octadecanoic acid, 2-(oxiranylmethoxy)ethyl ester)
• 64022-37-3(Hexanedioic acid, bis[2-(oxiranylmethoxy)ethyl] ester)
• 7501-44-2(Glycidyl Palmitate Standard)
• 65207-60-5(1H-Pyrrolizine-1-methanol,hexahydro-7-hydroxy-, (1R,7S,7aR)-rel-)