• 1. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 4. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 5. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361

Ethyl 2-(4-chloro-3-nitrophenyl)acetate (CAS No. 745053-53-6): A Comprehensive Overview in Modern Chemical Research

Ethyl 2-(4-chloro-3-nitrophenyl)acetate, a compound with the chemical identifier CAS No. 745053-53-6, has garnered significant attention in the field of chemical and pharmaceutical research due to its versatile applications and structural properties. This compound, characterized by its ethyl ester and nitro-substituted phenyl ring, serves as a crucial intermediate in the synthesis of various pharmacologically active molecules.

The molecular structure of Ethyl 2-(4-chloro-3-nitrophenyl)acetate consists of a phenyl ring substituted with both a chloro group at the fourth position and a nitro group at the third position, linked to an acetic acid ethyl ester moiety. This specific arrangement imparts unique reactivity and functionality, making it a valuable building block in organic synthesis. The presence of both electron-withdrawing nitro and electron-donating chloro groups enhances its utility in constructing complex molecular architectures.

In recent years, the pharmaceutical industry has shown increasing interest in developing novel therapeutic agents derived from nitroaromatic compounds. The nitro group in Ethyl 2-(4-chloro-3-nitrophenyl)acetate can be selectively reduced to an amine, providing a pathway to synthesize aminoaromatic derivatives that exhibit diverse biological activities. This transformation is particularly relevant in the development of antimicrobial and anti-inflammatory agents, where aminoaromatic compounds have demonstrated promising efficacy.

Moreover, the chloro-substituted phenyl ring in Ethyl 2-(4-chloro-3-nitrophenyl)acetate allows for further functionalization through nucleophilic aromatic substitution reactions. This property is exploited in the synthesis of heterocyclic compounds, which are integral to many modern drugs. Researchers have leveraged these reactions to develop novel scaffolds for kinase inhibitors, which are critical in treating cancers and inflammatory diseases.

Recent studies have highlighted the role of Ethyl 2-(4-chloro-3-nitrophenyl)acetate in the development of advanced materials. Its ability to undergo cross-coupling reactions with various organic halides has been utilized to create conjugated polymers with applications in organic electronics. These polymers exhibit excellent charge transport properties, making them suitable for use in organic light-emitting diodes (OLEDs) and photovoltaic cells.

The compound's stability under various reaction conditions also makes it a preferred choice for industrial-scale synthesis. Its resistance to hydrolysis and oxidation ensures high yields and purity in multi-step synthetic pathways. This reliability is crucial for pharmaceutical manufacturers who require consistent quality control throughout the production process.

From a synthetic chemistry perspective, Ethyl 2-(4-chloro-3-nitrophenyl)acetate serves as a versatile intermediate for constructing complex molecules. Its reactivity allows chemists to introduce diverse functional groups at specific positions on the aromatic ring, enabling the creation of structurally diverse libraries of compounds. This approach is particularly valuable in high-throughput screening programs aimed at identifying lead compounds for drug development.

The growing interest in green chemistry has also influenced the use of Ethyl 2-(4-chloro-3-nitrophenyl)acetate. Researchers are exploring solvent-free reactions and catalytic methods to minimize waste and energy consumption. These efforts align with global initiatives to promote sustainable chemical practices, ensuring that future generations inherit a cleaner and more efficient chemical industry.

In conclusion, Ethyl 2-(4-chloro-3-nitrophenyl)acetate (CAS No. 745053-53-6) is a multifaceted compound with significant implications in pharmaceuticals, materials science, and synthetic chemistry. Its unique structural features and reactivity make it an indispensable tool for researchers seeking to develop novel therapeutics and advanced materials. As scientific understanding continues to evolve, the applications of this compound are expected to expand further, driving innovation across multiple disciplines.

• 6093-34-1(4-Chloro-3,5-dinitrophenylacetic acid)
• 692288-62-3((4-Chloro-phenyl)-acetic acid 4-nitro-benzyl ester)
• 37777-68-7(4-Chloro-3-nitrophenylacetic acid)
• 792916-44-0(BENZENEACETIC ACID, 2,5-DICHLORO-4-NITRO-, ETHYL ESTER)
• 101486-10-6(BENZENEACETIC ACID, 4-CHLORO-3,5-DINITRO-, 3-IODO-2-PROPYNYL ESTER)
• 50537-08-1(Ethyl 2-(3-chloro-4-nitrophenyl)propanoate)
• 24646-28-4(Benzeneacetic acid, 3-chloro-alpha-methyl-4-nitro-, methyl ester)
• 627490-27-1(BENZENEPROPANOIC ACID, 4-CHLORO-3-NITRO-, METHYL ESTER)
• 300355-23-1(Methyl 2-(4-chloro-3-nitrophenyl)acetate)
• 409082-01-5(Benzeneacetic acid, 2-chloro-5-nitro-, ethyl ester)