• 1. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Methyl 2-(4-chloro-3-nitrophenyl)acetate: A Comprehensive Overview

Methyl 2-(4-chloro-3-nitrophenyl)acetate, commonly referenced by its CAS number 300355-23-1, is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, materials science, and pharmacology. This compound is characterized by its unique structure, which combines a methyl ester group with a substituted phenyl ring containing both chlorine and nitro functionalities. The presence of these groups imparts distinctive chemical properties, making it a valuable intermediate in various synthetic pathways and applications.

The synthesis of Methyl 2-(4-chloro-3-nitrophenyl)acetate typically involves multi-step processes that leverage the reactivity of aromatic rings under specific conditions. Recent advancements in catalytic methodologies have enabled more efficient and selective syntheses, reducing production costs and minimizing environmental impact. For instance, researchers have explored the use of palladium-catalyzed coupling reactions to construct the phenyl acetate moiety with high precision. These developments underscore the importance of continuous innovation in synthetic chemistry to meet the growing demand for this compound in diverse industries.

In terms of applications, Methyl 2-(4-chloro-3-nitrophenyl)acetate has found utility as an intermediate in the preparation of biologically active molecules. Its ability to undergo nucleophilic substitution reactions makes it particularly useful in drug discovery programs targeting various therapeutic areas. Recent studies have highlighted its role in the synthesis of potential anticancer agents, where the nitro group serves as a redox-sensitive moiety capable of triggering drug activation under specific cellular conditions. Additionally, the chlorine substituent enhances the compound's lipophilicity, facilitating its absorption across biological membranes.

The structural versatility of Methyl 2-(4-chloro-3-nitrophenyl)acetate also extends to its use in materials science. For example, it has been employed as a precursor in the fabrication of advanced polymers and coatings with tailored optical and electronic properties. The nitro group contributes to the stability of these materials under harsh conditions, while the ester functionality allows for controlled cross-linking during polymerization processes. Such applications highlight the compound's potential beyond traditional pharmaceutical uses.

From an environmental perspective, understanding the fate and behavior of Methyl 2-(4-chloro-3-nitrophenyl)acetate in natural systems is crucial for ensuring sustainable practices. Recent research has focused on its biodegradation pathways under aerobic and anaerobic conditions, revealing that microbial communities can metabolize this compound through enzymatic mechanisms targeting the ester and nitro functionalities. These findings are instrumental in developing eco-friendly disposal methods and minimizing ecological risks associated with its production and use.

In conclusion, Methyl 2-(4-chloro-3-nitrophenyl)acetate (CAS No. 300355-23-1) stands as a testament to the ingenuity of modern organic chemistry. Its unique structure, coupled with advancements in synthetic methodologies and application development, positions it as a key player in various scientific domains. As research continues to uncover new facets of its chemistry and utility, this compound is poised to remain at the forefront of innovation for years to come.

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