• 1. Aggregated-fluorescent detection of PFAS with a simple chip
  Cheng Fang,Jinjian Wu,Zahra Sobhani,Md. Al Amin,Youhong Tang Anal. Methods, 2019,11, 163-170
• 2. Alumina grafted SBA-15 sustainable bifunctional catalysts for direct cross-coupling of benzylic alcohols to diarylmethanes?
  Chandran Rajendran,Govindaswamy Satishkumar,Charlotte Lang,Eric M. Gaigneaux Catal. Sci. Technol., 2020,10, 2583-2592
• 3. Acenaphthenic hopanoids, a novel series of aromatised
  Teresita Carrillo-Hernández,Philippe Schaeffer,Pierre Albrecht Chem. Commun., 2001, 1976-1977
• 4. An amphipathic trans-acting phosphorothioate RNA element delivers an uncharged phosphorodiamidate morpholino sequence in mdx mouse myotubes?
  H. V. Jain,D. Verthelyi,S. L. Beaucage RSC Adv., 2017,7, 42519-42528
• 5. An aptamer-based keypad lock system?
  Yaqing Liu,Jiangtao Ren,Jing Li,Jiyang Liu,Erkang Wang Chem. Commun., 2012,48, 802-804

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

Exploring Methyl 2-methylpyrimidine-4-carboxylate (CAS No. 73955-55-2): Properties, Applications, and Innovations

Methyl 2-methylpyrimidine-4-carboxylate (CAS No. 73955-55-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This ester derivative of pyrimidine is characterized by its unique molecular structure, combining a methyl group at the 2-position and a carboxylate ester at the 4-position of the pyrimidine ring. Its versatility as a building block in synthetic chemistry makes it invaluable for developing novel drug candidates and functional materials.

In recent years, the demand for heterocyclic compounds like Methyl 2-methylpyrimidine-4-carboxylate has surged due to their role in designing kinase inhibitors and antiviral agents. Researchers are particularly interested in its potential to modulate biological pathways, a topic frequently searched in academic databases and AI-driven platforms. The compound’s CAS No. 73955-55-2 is often queried alongside terms such as "synthetic routes," "spectral data," and "scalable production methods," reflecting its industrial relevance.

From a structural perspective, the pyrimidine core of this compound is a key pharmacophore in many FDA-approved drugs. Its ester functionality allows for further derivatization, enabling chemists to explore structure-activity relationships (SAR) efficiently. This adaptability aligns with current trends in fragment-based drug discovery, a hot topic in medicinal chemistry forums and patent literature.

Environmental and sustainability concerns have also influenced research around Methyl 2-methylpyrimidine-4-carboxylate. Green chemistry approaches, such as catalytic esterification and solvent-free reactions, are being investigated to synthesize this compound with reduced ecological impact—a subject frequently discussed in ACS Sustainable Chemistry journals and LinkedIn groups focused on green synthesis.

Analytical characterization of CAS No. 73955-55-2 typically involves advanced techniques like NMR spectroscopy and HPLC-MS, which are critical for quality control in commercial batches. Startups and CROs (Contract Research Organizations) increasingly search for reliable suppliers of this compound, emphasizing the need for detailed COA (Certificate of Analysis) documentation—a frequently asked question in procurement discussions.

Looking ahead, the integration of AI-driven retrosynthesis tools is expected to revolutionize the production of Methyl 2-methylpyrimidine-4-carboxylate. Platforms like IBM RXN for Chemistry and BenchSci now feature this compound in predictive models, addressing user queries about "optimized synthetic pathways" and "cost-effective scaling." These innovations highlight its enduring importance in both academic and industrial settings.

• 2450-08-0(Methyl pyrimidine-4-carboxylate)
• 76240-14-7(Ethyl 2-methylpyrimidine-4-carboxylate)
• 6345-43-3(4,6-dimethyl pyrimidine-4,6-dicarboxylate)
• 1356111-30-2(Ethyl 2-(hydroxymethyl)pyrimidine-4-carboxylate)
• 944899-56-3(Ethyl 2-(chloromethyl)pyrimidine-4-carboxylate)
• 612088-38-7(4,6-PYRIMIDINEDICARBOXYLIC ACID, MONOMETHYL ESTER)
• 73955-53-0(Methyl 6-methylpyrimidine-4-carboxylate)
• 62846-82-6(Ethyl 4-Pyrimidinecarboxylate)
• 1196153-38-4(methyl 2-ethynylpyrimidine-4-carboxylate)
• 148149-29-5(Ethyl 6-methylpyrimidine-4-carboxylate)