Cas no 73418-86-7 (2-ethoxypyrimidin-5-amine)

2-ethoxypyrimidin-5-amine structure
2-ethoxypyrimidin-5-amine structure
Product Name:2-ethoxypyrimidin-5-amine
CAS No:73418-86-7
MF:C6H9N3O
MW:139.155160665512
MDL:MFCD10697094
CID:552246
PubChem ID:45080263
Update Time:2025-04-23

2-ethoxypyrimidin-5-amine Chemical and Physical Properties

Names and Identifiers

    • 5-Pyrimidinamine,2-ethoxy-
    • 2-Ethoxy-5-pyrimidinamine
    • 2-ethoxypyrimidin-5-amine
    • 5-Pyrimidinamine, 2-ethoxy- (9CI)
    • AKOS010387990
    • 73418-86-7
    • SY306298
    • AB58985
    • EN300-1225372
    • DTXSID50663922
    • D70974
    • YCA41886
    • F1912-0243
    • MFCD10697094
    • 5-amino-2-ethoxypyrimidine
    • SCHEMBL14865426
    • MDL: MFCD10697094
    • Inchi: 1S/C6H9N3O/c1-2-10-6-8-3-5(7)4-9-6/h3-4H,2,7H2,1H3
    • InChI Key: KPNZINMQYGYLCI-UHFFFAOYSA-N
    • SMILES: O(C1N=CC(=CN=1)N)CC

Computed Properties

  • Exact Mass: 139.074561919g/mol
  • Monoisotopic Mass: 139.074561919g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 2
  • Complexity: 91
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.2
  • Topological Polar Surface Area: 61?2

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Additional information on 2-ethoxypyrimidin-5-amine

5-Pyrimidinamine,2-ethoxy- (CAS No 73418-86-7): Properties, Applications, and Market Insights

5-Pyrimidinamine,2-ethoxy- (CAS No 73418-86-7) is a specialized pyrimidine derivative with growing significance in pharmaceutical and agrochemical research. This compound, characterized by its ethoxy-substituted pyrimidine core, has attracted attention due to its versatile chemical properties and potential applications in drug discovery. The molecular structure features a 2-ethoxy group attached to the pyrimidine amine backbone, which enhances its reactivity and binding affinity in biological systems.

The global market for pyrimidine-based compounds like 5-Pyrimidinamine,2-ethoxy- is experiencing steady growth, driven by increasing demand in medicinal chemistry and crop protection solutions. Recent studies highlight its role as a key intermediate in synthesizing novel therapeutic agents, particularly in oncology and antiviral research. Researchers are actively exploring its structure-activity relationships to develop more effective pharmaceutical candidates with improved bioavailability.

From a chemical perspective, 5-Pyrimidinamine,2-ethoxy- demonstrates excellent stability under standard laboratory conditions, making it suitable for various synthetic applications. Its solubility profile (soluble in common organic solvents like DMSO and ethanol) facilitates its use in diverse reaction systems. The compound's molecular weight of 139.15 g/mol and precise structural configuration contribute to its growing popularity among synthetic chemists.

In pharmaceutical applications, this ethoxy-substituted pyrimidine serves as a valuable building block for developing kinase inhibitors and nucleoside analogs. The 2-ethoxy modification enhances the compound's ability to interact with biological targets while maintaining favorable pharmacokinetic properties. Current research focuses on its potential in treating viral infections and certain cancers, aligning with today's healthcare priorities.

The agrochemical industry has also recognized the potential of 5-Pyrimidinamine,2-ethoxy- as a precursor for novel crop protection agents. Its structural features enable the development of compounds with improved pest resistance and environmental profiles. This application addresses the growing demand for sustainable agriculture solutions, a key concern in modern farming practices.

Quality control standards for CAS 73418-86-7 typically require high purity levels (>98%), verified through advanced analytical techniques like HPLC and NMR spectroscopy. Manufacturers emphasize strict synthesis protocols to ensure batch-to-batch consistency, meeting the rigorous demands of research and industrial applications. Proper storage conditions (typically 2-8°C in airtight containers) maintain the compound's stability over extended periods.

Emerging trends in green chemistry have influenced the production methods for 2-ethoxy-5-pyrimidinamine, with researchers developing more efficient and environmentally friendly synthesis routes. These advancements align with the pharmaceutical industry's push toward sustainable manufacturing practices while maintaining cost-effectiveness and scalability.

From a regulatory standpoint, 5-Pyrimidinamine,2-ethoxy- currently falls under standard chemical handling guidelines without special restrictions in most jurisdictions. However, researchers and manufacturers should always consult the latest safety data sheets and regional regulations before handling or transporting the compound.

The scientific literature contains numerous references to pyrimidine amine derivatives similar to CAS 73418-86-7, highlighting their importance in modern chemistry. Patent databases reveal growing interest in this chemical space, particularly for applications in precision medicine and targeted therapies, reflecting broader trends in pharmaceutical development.

Future research directions for 5-Pyrimidinamine,2-ethoxy- may explore its potential in bioconjugation chemistry and prodrug development, areas gaining significant attention in drug delivery innovation. The compound's balanced lipophilicity and hydrogen bonding capacity make it particularly suitable for these emerging applications.

For researchers sourcing 2-ethoxy-5-pyrimidinamine, it's essential to verify suppliers' credentials and quality assurance processes. Reputable manufacturers typically provide comprehensive analytical data and certificates of analysis, ensuring the material meets specific research requirements. Current market prices vary based on purity and quantity, with bulk purchases often available at competitive rates.

In conclusion, 5-Pyrimidinamine,2-ethoxy- (CAS No 73418-86-7) represents an important chemical building block with diverse applications across multiple industries. Its unique structural features and synthetic versatility position it as a valuable tool for researchers developing next-generation pharmaceutical and agrochemical solutions. As scientific understanding of pyrimidine chemistry continues to advance, this compound will likely play an increasingly significant role in addressing current and future challenges in human health and agriculture.

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