• 1. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 2. Excited state characterization of carbonyl containing carotenoids: a comparison between single and multireference descriptions?
  Riccardo Spezia,Stefan Knecht,Benedetta Mennucci Phys. Chem. Chem. Phys., 2017,19, 17156-17166
• 3. Fe3O4@SiO2 core–shell nanoparticles for biomedical purposes: adverse effects on blood cells?
  C. Achilli,G. F. Guidetti,A. Ciana,D. Capsoni,G. Minetti Biomater. Sci., 2016,4, 1417-1421
• 4. Excitonic and vibrational coherence in artificial photosynthetic systems studied by negative-time ultrafast laser spectroscopy
  Dongjia Han,Bing Xue,Juan Du,Tomohiro Miyatake,Hitoshi Tamiaki,Xin Xing,Wei Yuan,Yanyan Li Phys. Chem. Chem. Phys., 2016,18, 24252-24260
• 5. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Steroid lactones Brassinolides and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Brassinolides and derivatives

Brassinolide (CAS No. 72962-43-7): A Comprehensive Overview of Its Bioactivity and Recent Research Findings

Brassinolide, a member of the brassinosteroid family, is a plant hormone with significant implications in both plant biology and pharmaceutical research. With the chemical formula C₂₉H₄₂O₆ and a CAS number of CAS No. 72962-43-7, this compound has garnered considerable attention due to its diverse biological activities. This article provides an in-depth exploration of Brassinolide, focusing on its structural characteristics, pharmacological effects, and the latest advancements in its application across various fields.

The discovery of Brassinolide dates back to the 1970s when it was first isolated from rapeseed extracts. Since then, extensive research has elucidated its role in promoting plant growth and development. Structurally, Brassinolide belongs to a class of polyhydroxysteroids, characterized by a cyclopentane ring fused to a steroidal backbone. This unique structure enables it to interact with specific cellular receptors, triggering a cascade of signaling pathways that regulate processes such as cell elongation, division, and differentiation.

In recent years, the pharmacological potential of Brassinolide has been extensively studied, particularly in the context of human health and disease management. One of the most notable areas of research has been its anti-inflammatory properties. Studies have demonstrated that Brassinolide can modulate inflammatory responses by inhibiting the production of pro-inflammatory cytokines such as TNF-α and IL-6. This has led to investigations into its potential as a therapeutic agent for chronic inflammatory conditions like rheumatoid arthritis and inflammatory bowel disease.

In addition to its anti-inflammatory effects, Brassinolide has shown promise in enhancing immune function. Research indicates that this compound can stimulate the proliferation and activity of immune cells, including lymphocytes and macrophages. Such immunomodulatory properties make it a candidate for applications in immunotherapy and vaccine development. Furthermore, studies have explored its potential role in wound healing, where Brassinolide has been found to accelerate tissue repair by promoting angiogenesis and collagen synthesis.

The structural analogs of Brassinolide, often referred to as long-tail keywords such as "brassinolide derivatives," have also been subjects of intense research. These derivatives exhibit enhanced bioavailability and targeted action, making them valuable tools in drug discovery. For instance, modifications to the hydroxyl groups on the steroid backbone have resulted in compounds with improved efficacy in treating metabolic disorders. Such derivatives are being tested for their potential in managing conditions like diabetes and obesity by regulating glucose homeostasis and lipid metabolism.

The latest advancements in synthetic chemistry have enabled the development of novel delivery systems for Brassinolide. Lipid-based nanoparticles and plant-derived carriers have been investigated for their ability to enhance the stability and bioavailability of this hormone. These innovations are particularly significant for topical applications, where maintaining therapeutic concentrations over extended periods is crucial. Preliminary clinical trials have shown encouraging results, suggesting that these formulations could revolutionize the treatment of skin disorders and other localized conditions.

The role of Brassinolide in neuroprotection has also emerged as a promising area of research. Studies have indicated that this compound can cross the blood-brain barrier and exert neuroprotective effects against oxidative stress and neuroinflammation. These findings have sparked interest in exploring its potential for treating neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Additionally, research suggests that Brassinolide may have anti-cancer properties by inducing apoptosis in tumor cells while sparing healthy cells.

The agricultural applications of Brassinolide remain one of its most significant contributions. Beyond its well-documented role in enhancing plant growth, recent studies have highlighted its ability to improve stress tolerance in crops. This includes resistance to abiotic stresses such as drought, salinity, and extreme temperatures. By integrating biostimulants like Brassinolide, farmers can achieve higher yields while reducing reliance on synthetic fertilizers and pesticides.

In conclusion, Brassinolide (CAS No. 72962-43-7) is a multifaceted compound with far-reaching implications in pharmaceuticals and agriculture. Its unique bioactivity profile has opened new avenues for therapeutic interventions across various diseases, while its agricultural benefits contribute significantly to sustainable farming practices. As research continues to uncover new applications for this remarkable hormone, it is clear that Brassinolide will remain at the forefront of scientific innovation for years to come.

• 78821-42-8(6H-Benz[c]indeno[5,4-e]oxepin-6-one,1-[(1S,2S,3S,4R)-2,3-dihydroxy-1,4,5-trimethylhexyl]hexadecahydro-8,9-dihydroxy-10a,12a-dimethyl-,(1R,3aS,3bS,6aS,8S,9R,10aR,10bS,12aS)-)
• 93860-61-8( )
• 110369-52-3(22(S),23(S)-HOMOBRASSINOLIDE)
• 78780-31-1((22S,23S)-28-Norbrassinolide)
• 163514-19-0(3,24-Diepibrassinolide)
• 77736-43-7(28-Nor Brassinolide)
• 74174-44-0((22RS,23RS)-28-Homo Brassinolide)
• 78821-43-9(Epibrassinolide)
• 144071-55-6(2-deoxybrassinolide)
• 80483-89-2((22S,23S)-Homobrassinolide)