• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
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• 3. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 4. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
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  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines

Introduction to 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine (CAS No. 72600-67-0)

2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine, identified by its CAS number 72600-67-0, is a fluorinated pyridine derivative that has garnered significant attention in the field of pharmaceutical and agrochemical research. This compound, characterized by its chloro, fluoro, and trifluoromethyl substituents, exhibits unique chemical properties that make it a valuable intermediate in the synthesis of various biologically active molecules.

The structural features of 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine contribute to its versatility in medicinal chemistry. The presence of a chlorine atom at the 2-position enhances its reactivity in nucleophilic substitution reactions, while the fluorine atoms at the 3- and 5-positions introduce electron-withdrawing effects that modulate the electronic properties of the pyridine ring. Additionally, the trifluoromethyl group at the 5-position further strengthens these effects, making the compound an attractive scaffold for designing novel compounds with enhanced binding affinity and metabolic stability.

In recent years, 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine has been extensively studied for its potential applications in drug discovery. Its fluorinated structure is particularly relevant in the development of kinase inhibitors, which are critical targets in oncology and inflammatory diseases. For instance, fluorinated pyridines have been shown to improve oral bioavailability and resistance to metabolic degradation, making them ideal for therapeutic applications.

One of the most compelling aspects of 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine is its role as a key intermediate in the synthesis of small-molecule inhibitors targeting protein-protein interactions. These interactions are often implicated in various diseases, including cancer and neurodegenerative disorders. By leveraging the reactivity of the chlorine and fluorine substituents, researchers can design molecules that selectively modulate these interactions, leading to potential therapeutic breakthroughs.

Recent advances in computational chemistry have further highlighted the importance of 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine in drug design. Molecular modeling studies have demonstrated that the compound can be effectively incorporated into drug candidates to enhance their binding affinity to target proteins. Specifically, the fluorine atoms have been shown to improve hydrophobic interactions with aromatic residues in protein active sites, while the chlorine atom facilitates polar interactions through hydrogen bonding or coordination with charged residues.

The agrochemical industry has also recognized the potential of 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine as a building block for developing novel pesticides. Fluorinated pyridines are known for their ability to enhance insecticidal and herbicidal activity due to their stability under environmental conditions and their interaction with biological targets in pests. This has led to several patents and commercial products that incorporate derivatives of this compound.

In conclusion, 2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine (CAS No. 72600-67-0) is a multifaceted compound with significant applications in pharmaceuticals and agrochemicals. Its unique structural features make it an invaluable intermediate for synthesizing biologically active molecules with improved pharmacokinetic properties. As research continues to uncover new therapeutic targets and synthetic methodologies, the role of this compound is expected to expand further, solidifying its position as a cornerstone in modern drug discovery.

• 34552-15-3(2-Chloro-3-fluoro-5-methylpyridine)
• 72587-20-3(2-Chloro-5-fluoro-3-(trifluoromethyl)pyridine)
• 628692-22-8(2-Chloro-3-fluoro-4-(trifluoromethyl)pyridine)
• 1227511-50-3(2-Chloro-4-fluoro-5-(trifluoromethyl)pyridine)
• 1806802-56-1(2,4-Dichloro-5-(difluoromethyl)-3-fluoropyridine)
• 1099598-11-4(2,6-Dichloro-3-fluoro-5-(trifluoromethyl)pyridine)
• 1374659-31-0(2-chloro-3-(difluoromethyl)-5-fluoro-pyridine)
• 52334-81-3(2-chloro-5-(trifluoromethyl)pyridine)
• 1374659-39-8(2,6-dichloro-3-(difluoromethyl)-5-fluoropyridine)
• 431942-66-4(Pyridine, 2-chloro-3-fluoro-4-methyl-5-(trifluoromethyl)-)