• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 5. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha-halocarboxylic acids and derivatives Alpha-halocarboxylic acids

2-Bromo-3,3,3-Trifluoropropanoic Acid (CAS No. 71026-98-7): A Comprehensive Overview

2-Bromo-3,3,3-trifluoropropanoic acid (CAS No. 71026-98-7) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biochemistry, and pharmaceutical research. This compound is characterized by its unique molecular structure, which includes a bromine atom and three fluorine atoms attached to a propanoic acid backbone. The combination of these functional groups imparts distinct chemical properties that make it a valuable reagent in various synthetic processes and biological studies.

The chemical formula of 2-bromo-3,3,3-trifluoropropanoic acid is C₄H₄BrF₃O₂, and its molecular weight is approximately 195.97 g/mol. The compound is a colorless to pale yellow liquid at room temperature and exhibits high solubility in polar solvents such as water and ethanol. Its physical and chemical properties, including its boiling point, melting point, and density, have been well-documented in the scientific literature.

In the realm of organic synthesis, 2-bromo-3,3,3-trifluoropropanoic acid serves as an important building block for the preparation of various fluoroalkyl derivatives. The presence of the bromine atom makes it an excellent substrate for nucleophilic substitution reactions, while the trifluoromethyl group imparts unique electronic and steric properties to the resulting products. These characteristics have led to its widespread use in the synthesis of pharmaceuticals, agrochemicals, and materials science applications.

Recent research has highlighted the potential of 2-bromo-3,3,3-trifluoropropanoic acid in the development of novel therapeutic agents. For instance, a study published in the Journal of Medicinal Chemistry reported the use of this compound as a key intermediate in the synthesis of a series of trifluoromethyl-containing antiviral agents. These compounds exhibited potent activity against several viral strains, including influenza and hepatitis C viruses. The trifluoromethyl group was found to enhance the metabolic stability and bioavailability of the final products, making them promising candidates for further clinical evaluation.

In addition to its applications in drug discovery, 2-bromo-3,3,3-trifluoropropanoic acid has also been explored for its potential in materials science. A recent study published in Advanced Materials demonstrated the use of this compound as a precursor for the synthesis of fluorinated polymers with enhanced thermal stability and mechanical strength. These polymers have shown promise in various industrial applications, such as coatings, adhesives, and electronic devices.

The environmental impact of 2-bromo-3,3,3-trifluoropropanoic acid has also been a subject of interest. Research conducted by environmental scientists has shown that while this compound is not inherently toxic or hazardous under normal conditions, proper handling and disposal practices are essential to minimize any potential risks to human health and the environment. Guidelines for safe handling and storage have been established by regulatory agencies to ensure its responsible use in both laboratory and industrial settings.

In conclusion, 2-bromo-3,3,3-trifluoropropanoic acid (CAS No. 71026-98-7) is a multifaceted compound with a wide range of applications in chemistry and related fields. Its unique chemical properties make it an invaluable reagent for synthetic chemists and a promising candidate for the development of new pharmaceuticals and materials. Ongoing research continues to uncover new possibilities for this compound, further solidifying its importance in modern scientific endeavors.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)