Cas no 70588-04-4 (4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl)
4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl Chemical and Physical Properties
Names and Identifiers
-
- 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl
- 1,4-Nitronaphthylamine
- 1-Amino-4-nitronaphthalene
- 1-Naphthalenamine
- 1-NAPHTHYLAMINE, 4-NITRO-
- 4-Amino-1-nitronaphthalene
- 4-amino-1-oxyl-2,2,6,6-tetramethylpiperidine-d17
- 4-amino-perdeutero-2,2,6,6-tetramethylpiperidine-N-oxyl
- 4-Nitro-1-naphthalenamine
- 4-Nitro-1-naphthamine
- 4-Nitro-1-naphthylamine
- 4-nitro-1-naphtylamine
- 4-nitronaphthalen-1-yl-amine
- amino-4-nitronaphthalene
- 4-Amino-2,2,6,6-tetramethylpiperidine 1-oxide
- CHEMBL607022
- AM20080358
- DTXSID0065808
- 4-Amino-2,2,6,6-tetramethylpiperidine 1-Oxyl
- AS-17420
- 2,2,6,6-tetramethyl-4-aminopiperidine-1-oxyl
- 4-Amino-2,2,6,6-tetramethylpiperidinyloxyl
- CS-W002004
- CHEBI:180672
- AKOS005254395
- 2,2,6,6-tetramethylpiperidine-N-oxyl-4-amine
- SB41070
- NSC 239129
- 4-Amino-2,2,6,6-tetramethylpiperidine 1-oxyl, free radical
- 70588-04-4
- A1343
- EINECS 238-738-2
- 4-Amino-TEMPO free radical
- CCRIS 8498
- 4-Amino-2,2,6,6-tetramethylpiperidine-1-oxyl, free rad Tempamine
- 4-Amino-TEMPO, free radical
- FT-0617614
- 4-amino-2,2,6,6-tetramethylpiperidinyloxy
- 1-Piperidinyloxy,4-amino-2,2,6,6-tetramethyl-
- 4-Amino-2,2,6,6-tetramethylpiperidine1-Oxyl
- 4-Amino-TEMPO, free radical, 97%
- 1007462-04-5
- 4-Amino-TEMPO-piperidinyl-d17, >=98 atom % D, >=98% (CP)
-
- MDL： MFCD01075413
- Inchi： 1S/C9H19N2O/c1-8(2)5-7(10)6-9(3,4)11(8)12/h7H,5-6,10H2,1-4H3
- InChI Key： XUXUHDYTLNCYQQ-UHFFFAOYSA-N
- SMILES： [O]N1C(C)(C)CC(CC1(C)C)N |^1:0|
Computed Properties
- Exact Mass: 171.149738234g/mol
- Monoisotopic Mass: 171.149738234g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 12
- Rotatable Bond Count: 0
- Complexity: 159
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 0.6
- Topological Polar Surface Area: 30.3?2
Experimental Properties
- Melting Point: 38-41?°C (lit.)
4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl Security Information
-
Symbol:
- Signal Word：Warning
- Hazard Statement： H315-H319-H335
- Warning Statement： P305+P351+P338
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： 26-36
-
Hazardous Material Identification：
- Risk Phrases：36/37/38
4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | A630261-10mg |
4-Amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl |
70588-04-4 | 10mg |
$ 316.00 | 2023-04-19 |
4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl Related Literature
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Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
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Hamid Heydari,Mohammad B. Gholivand New J. Chem., 2017,41, 237-244
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Zhonghua Xiang,Chuanqi Fang,Sanhua Leng,Dapeng Cao J. Mater. Chem. A, 2014,2, 7662-7665
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Jieun Kim,Han-Saem Park,Tae-Hee Kim,Sung Yeol Kim,Hyun-Kon Song Phys. Chem. Chem. Phys., 2014,16, 5295-5300
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Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
Additional information on 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl
Research Brief on 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS: 70588-04-4): Recent Advances and Applications
4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl (CAS: 70588-04-4) is a deuterated nitroxide radical that has garnered significant attention in the field of chemical biology and medicinal research due to its unique properties as a spin label and its potential applications in studying biomolecular dynamics. This research brief synthesizes the latest findings on this compound, focusing on its synthesis, characterization, and applications in biomedical research.
Recent studies have highlighted the role of 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl in electron paramagnetic resonance (EPR) spectroscopy. The deuterium substitution in the compound enhances its stability and reduces line broadening, making it an excellent probe for investigating protein dynamics and membrane interactions. A 2023 study published in the Journal of Physical Chemistry B demonstrated its utility in mapping conformational changes in membrane proteins, providing insights into their functional mechanisms.
In addition to its spectroscopic applications, this compound has been explored for its potential in drug delivery systems. Researchers have utilized its radical scavenging properties to develop targeted therapies for oxidative stress-related diseases. A recent preclinical study (2024) reported in Chemical Communications showed that 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl could effectively mitigate oxidative damage in neuronal cells, suggesting its promise as a neuroprotective agent.
The synthesis of 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl has also seen advancements. A novel catalytic deuteration method, published in Organic Letters (2023), offers a more efficient route to produce high-purity deuterated nitroxides, including this compound. This breakthrough addresses previous challenges related to yield and isotopic purity, facilitating broader adoption in research and therapeutic development.
Looking ahead, the integration of 4-amino-2,2,6,6-tetramethylpiperidine-d17-1-oxyl with advanced imaging techniques, such as super-resolution microscopy, is an emerging area of interest. Preliminary results from collaborative studies indicate its potential to bridge EPR data with high-resolution structural biology, offering a more comprehensive understanding of biomolecular systems. These developments underscore the compound's versatility and its growing importance in both fundamental and applied research.
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