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  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Recent Advances in the Study of 1-4-(4-Pyridinyl)phenyl-ethanone (CAS: 70581-00-9) in Chemical Biology and Pharmaceutical Research

The compound 1-4-(4-Pyridinyl)phenyl-ethanone (CAS: 70581-00-9) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential applications in drug discovery and development. This research briefing aims to provide a comprehensive overview of the latest findings related to this compound, including its synthesis, biological activity, and therapeutic potential. The information presented herein is based on a thorough review of recent academic literature, industry reports, and technical documents.

Recent studies have highlighted the unique structural features of 1-4-(4-Pyridinyl)phenyl-ethanone, which make it a promising candidate for the development of novel therapeutic agents. The compound's pyridinyl and phenyl groups contribute to its ability to interact with various biological targets, including enzymes and receptors. Researchers have explored its potential as an inhibitor of key signaling pathways involved in inflammation, cancer, and neurodegenerative diseases. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in modulating the activity of protein kinases, which are critical targets in oncology.

In addition to its biological activity, advancements in the synthetic routes for 1-4-(4-Pyridinyl)phenyl-ethanone have been reported. A recent publication in Organic Letters detailed an optimized method for its synthesis, which improves yield and purity while reducing environmental impact. This development is particularly relevant for scaling up production for preclinical and clinical studies. Furthermore, computational modeling studies have provided insights into the compound's binding modes and interactions with biological targets, facilitating the design of derivatives with enhanced potency and selectivity.

The therapeutic potential of 1-4-(4-Pyridinyl)phenyl-ethanone extends beyond its direct biological effects. Researchers have investigated its role as a scaffold for the development of multifunctional drugs. For example, a 2022 study in Bioorganic & Medicinal Chemistry Letters reported the design of hybrid molecules combining this scaffold with other pharmacophores, resulting in compounds with dual activity against inflammatory and infectious diseases. Such innovations underscore the versatility of 1-4-(4-Pyridinyl)phenyl-ethanone in drug design.

Despite these promising findings, challenges remain in the development of 1-4-(4-Pyridinyl)phenyl-ethanone-based therapeutics. Issues such as bioavailability, metabolic stability, and potential off-target effects need to be addressed through further research. Recent efforts have focused on structural modifications to improve these properties, as evidenced by a 2023 study in the European Journal of Medicinal Chemistry, which reported the synthesis of analogs with improved pharmacokinetic profiles.

In conclusion, 1-4-(4-Pyridinyl)phenyl-ethanone (CAS: 70581-00-9) represents a valuable compound in the toolkit of medicinal chemists and pharmacologists. Its diverse biological activities and potential for structural optimization make it a promising candidate for the development of next-generation therapeutics. Continued research into its mechanisms of action, synthetic accessibility, and therapeutic applications will be essential for translating these findings into clinical benefits. This briefing serves as a timely update on the current state of research and highlights the exciting opportunities for future investigations in this area.

• 72034-25-4(Phenyl(pyridin-4-yl)methanone hydrochloride)
• 143620-85-3(Ethanone, 1-[4-(4-pyridinylcarbonyl)phenyl]-)
• 1122-54-9(4-Acetylpyridine)
• 208190-04-9(3-(Pyridin-4-yl)benzaldehyde)
• 99163-12-9(4-Pyridin-4-yl-benzaldehyde)
• 14548-46-0(4-Benzoylpyridine)
• 6918-15-6(dipyridin-4-ylmethanone)
• 14548-30-2(Methanone, (4-methylphenyl)-4-pyridinyl-)
• 90395-45-2(1-(4-(Pyridin-3-yl)phenyl)ethanone)
• 918540-98-4(1,2-Ethanedione, 1-[1,1'-biphenyl]-3-yl-2-(4-pyridinyl)-)