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  Neha Sharma,Himanshi Sharma,Manoj Kumar,Maria Grishina,Unnat Pandit,Poonam,Brijesh Rathi Org. Biomol. Chem. 2022 20 6673
• 2. Nickel catalyzed three-component sulfonylation of non-activated alkyl chlorides
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

2-Chloro-5-(chloromethyl)pyridine (CAS No. 70258-18-3): An Overview of Its Properties, Applications, and Recent Research Developments

2-Chloro-5-(chloromethyl)pyridine (CAS No. 70258-18-3) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceuticals. This compound, also known as 2-chloro-5-chloromethylpyridine or CCMP, is characterized by its unique structure, which includes a pyridine ring substituted with a chloromethyl group and a chlorine atom at specific positions. The combination of these functional groups imparts distinct chemical properties and reactivity, making it a valuable intermediate in various synthetic pathways.

The molecular formula of 2-Chloro-5-(chloromethyl)pyridine is C₆H₅Cl₂N, and its molecular weight is approximately 164.01 g/mol. The compound is typically obtained as a colorless to pale yellow liquid with a characteristic odor. It is soluble in common organic solvents such as ethanol, acetone, and dichloromethane but has limited solubility in water. These physical properties make it suitable for use in a variety of chemical reactions and processes.

In the realm of synthetic chemistry, 2-Chloro-5-(chloromethyl)pyridine serves as an important building block for the synthesis of more complex molecules. Its reactivity is primarily centered around the chloromethyl group, which can undergo nucleophilic substitution reactions to form new carbon-nucleophile bonds. This versatility has led to its widespread use in the preparation of pyridine derivatives, which are essential components in many pharmaceuticals and agrochemicals.

Recent research has highlighted the potential applications of 2-Chloro-5-(chloromethyl)pyridine in the development of novel therapeutic agents. For instance, studies have shown that certain pyridine derivatives derived from this compound exhibit potent antiviral and antibacterial activities. A notable example is the synthesis of N-substituted pyridinium salts, which have been found to be effective against a range of viral infections, including influenza and herpes simplex virus (HSV). These findings underscore the importance of 2-Chloro-5-(chloromethyl)pyridine as a key intermediate in the design of new antiviral drugs.

In addition to its pharmaceutical applications, 2-Chloro-5-(chloromethyl)pyridine has also been explored for its potential in agrochemicals. Pyridine-based compounds are known for their herbicidal and insecticidal properties, and recent studies have demonstrated that derivatives of 2-Chloro-5-(chloromethyl)pyridine can be used to develop environmentally friendly pesticides. These compounds are designed to target specific pests while minimizing their impact on non-target organisms and the environment.

The environmental fate and toxicity of 2-Chloro-5-(chloromethyl)pyridine have been subjects of ongoing research. Studies have shown that while the compound itself may not be highly toxic, its breakdown products can pose environmental risks if not properly managed. Therefore, efforts are being made to develop more sustainable synthetic routes and disposal methods to minimize any potential adverse effects.

In conclusion, 2-Chloro-5-(chloromethyl)pyridine (CAS No. 70258-18-3) is a multifaceted compound with significant applications in various fields. Its unique chemical structure and reactivity make it an invaluable intermediate in synthetic chemistry, while its potential in pharmaceuticals and agrochemicals highlights its importance in developing new therapeutic agents and environmentally friendly pesticides. As research continues to uncover new properties and applications, the role of 2-Chloro-5-(chloromethyl)pyridine is likely to expand further, contributing to advancements in multiple scientific disciplines.

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