• 1. 988. Triazanaphthalenes. Part II. Covalent hydration in 1,4,6-triazanaphthalenes
  Adrien Albert,G. B. Barlin J. Chem. Soc. 1963 5156
• 2. Ionisation constants of heterocyclic substances. Part VIII. 1,3,5-Triazaindenes
  G. B. Barlin J. Chem. Soc. B 1966 285

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives 2-halopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines 2-halopyridines

Comprehensive Overview of 2-Chloro-4-hydrazinopyridine (CAS No. 700811-29-6): Properties, Applications, and Industry Insights

2-Chloro-4-hydrazinopyridine (CAS No. 700811-29-6) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This pyridine derivative is characterized by its unique molecular structure, combining a chloro substituent at the 2-position and a hydrazine functional group at the 4-position. Its versatility as a chemical intermediate makes it invaluable for synthesizing complex molecules, particularly in drug discovery and material science.

Recent trends in AI-driven drug discovery and green chemistry have amplified interest in compounds like 2-Chloro-4-hydrazinopyridine. Researchers frequently search for "pyridine-based building blocks" or "hydrazine derivatives in medicinal chemistry," reflecting its relevance in modern synthetic routes. The compound's CAS number 700811-29-6 is often queried in patent databases, underscoring its industrial importance.

From a structural perspective, the electron-withdrawing chloro group enhances reactivity in nucleophilic substitution reactions, while the hydrazino moiety offers opportunities for condensation reactions—key for creating heterocyclic scaffolds. This dual functionality aligns with the growing demand for multifunctional intermediates in high-throughput screening libraries.

In pharmaceutical applications, 2-Chloro-4-hydrazinopyridine serves as a precursor for biologically active compounds targeting enzyme inhibition. Its role in developing kinase inhibitors and antimicrobial agents is frequently cited in recent literature. The compound's structure-activity relationship (SAR) is a hot topic, with computational chemists using molecular docking simulations to predict its derivatives' efficacy.

Environmental and regulatory considerations are also critical. The compound's synthetic pathways are being optimized to reduce waste, aligning with sustainable chemistry principles. Analytical methods like HPLC purity testing and LC-MS characterization ensure compliance with Good Manufacturing Practices (GMP) standards.

Market analyses reveal rising demand for custom synthesis of 700811-29-6, particularly from contract research organizations (CROs). Suppliers emphasize batch-to-batch consistency and scalable production, addressing needs in preclinical development.

Future prospects include exploring 2-Chloro-4-hydrazinopyridine in catalysis and material science, where its chelating properties could enable innovations in coordination polymers. As structure-based drug design evolves, this compound's role in fragment-based approaches is anticipated to expand.

• 2587-02-2(4-Amino-2,6-dichloropyridine)
• 14432-12-3(2-chloropyridin-4-amine)
• 1049730-38-2(2,6-dichloropyridin-4-amine Hydrochloride)
• 865705-31-3(2-Chloro-5-hydrazinopyridine hydrochloride)
• 883865-21-2(2-Chloro-4-hydrazinylpyridine hydrochloride)
• 2897-42-9(2-Chloropyridin-4-amine Hydrochloride)
• 2377920-18-6(2-Chloro-4-[2-(propan-2-ylidene)hydrazin-1-yl]pyridine)
• 145934-89-0(2-Chloro-5-hydrazinylpyridine)
• 1955506-81-6(2-Chloro-4-hydrazinylpyridine dihydrochloride)
• 893616-23-4(2,6-dichloro-4-hydrazinylpyridine)