• 1. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 2. An analysis of the WTC fires using CIB correlations and simple modeling
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• 3. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 5. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles Benzothiazoles
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Benzothiazoles

Comprehensive Overview of 4,6-Dibromobenzothiazole (CAS No. 700-48-1): Properties, Applications, and Industry Insights

4,6-Dibromobenzothiazole (CAS 700-48-1) is a halogenated heterocyclic compound that has garnered significant attention in pharmaceutical, agrochemical, and material science research. With the molecular formula C₇H₃Br₂NS, this brominated benzothiazole derivative exhibits unique reactivity due to its electron-deficient aromatic system, making it a versatile intermediate in synthetic chemistry. The compound's high purity and thermal stability have positioned it as a critical building block for advanced applications.

Recent trends in green chemistry and sustainable synthesis have driven interest in optimizing production methods for 4,6-Dibromobenzothiazole. Researchers are exploring catalytic bromination techniques to improve yield while minimizing waste—a response to growing environmental concerns. The compound's role in OLED materials and organic semiconductors has also surged, aligning with the global push for energy-efficient display technologies. Analytical techniques like HPLC and GC-MS are routinely employed to verify the compound's purity, reflecting industry demands for precise quality control.

In pharmaceutical applications, 700-48-1 serves as a precursor for bioactive molecules targeting inflammation and microbial resistance—topics dominating medical research. Its structural motif appears in kinase inhibitors and antiviral agents, addressing current healthcare challenges. The agrochemical sector utilizes this intermediate in developing next-generation pesticides with improved selectivity, responding to stricter environmental regulations worldwide.

From a commercial perspective, 4,6-Dibromobenzothiazole suppliers emphasize batch-to-batch consistency, with technical specifications typically listing ≥98% purity. Storage recommendations highlight protection from moisture and light to maintain stability—a key consideration for industrial users. Pricing trends reflect fluctuations in bromine feedstock availability, a factor monitored by procurement specialists across industries.

Emerging studies investigate the compound's potential in corrosion inhibition and polymer modification, expanding its utility beyond traditional applications. Regulatory compliance remains paramount, with manufacturers adhering to REACH and other global chemical management frameworks. As analytical instrumentation advances, new characterization data continues to refine our understanding of this structurally intriguing molecule.

The scientific community actively publishes on 700-48-1 synthetic routes, with recent journals highlighting atom-economical approaches. Patent analysis reveals growing IP activity around benzothiazole derivatives, particularly in electronic materials. For researchers, the compound's X-ray crystallography data provides valuable insights into molecular packing—information critical for materials engineering.

Industrial scale-up challenges for 4,6-Dibromobenzothiazole production often focus on bromine utilization efficiency, with process intensification strategies gaining traction. Quality benchmarks now frequently include residual solvent limits, reflecting heightened purity requirements in end-use applications. The compound's spectroscopic fingerprints (IR, NMR) serve as important reference standards for analytical laboratories worldwide.

Looking ahead, innovation in heterocyclic chemistry will likely uncover new applications for this brominated scaffold. Its compatibility with cross-coupling reactions maintains relevance in medicinal chemistry, while materials scientists value its electron-transport properties. With proper handling protocols and advancing synthetic methodologies, CAS 700-48-1 continues to demonstrate multifaceted importance across scientific disciplines.

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