Cas no 685513-91-1 (5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine)

5-Bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine is a halogenated and silyl-protected pyrrolopyridine derivative, notable for its utility in organic synthesis and pharmaceutical research. The bromo and fluoro substituents enhance its reactivity in cross-coupling reactions, such as Suzuki or Buchwald-Hartwig couplings, enabling precise functionalization. The tris(isopropyl)silyl (TIPS) group provides steric protection for the pyrrole nitrogen, improving stability during synthetic transformations. This compound serves as a versatile intermediate for constructing complex heterocyclic scaffolds, particularly in drug discovery targeting kinase inhibitors or other biologically active molecules. Its well-defined reactivity and protective group strategy make it valuable for controlled derivatization in medicinal chemistry applications.
5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine structure
685513-91-1 structure
Product Name:5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine
CAS No:685513-91-1
MF:C16H24BrFN2Si
MW:371.363067626953
MDL:MFCD11616414
CID:832957
PubChem ID:49758946
Update Time:2025-10-29

5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine Chemical and Physical Properties

Names and Identifiers

    • 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-4-fluoro-1-[tris(1-methylethyl)silyl]-
    • 5-Bromo-4-fluoro-1-(triisopropylsilanyl)-7-azaindole
    • 5-Brom-4-<wbr>
    • 5-bromo-4<wbr>
    • LogP
    • 5-bromo-4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
    • C16H24BrFN2Si
    • AIJAFOFKGPWSSO-UHFFFAOYSA-N
    • 3327AH
    • PB10927
    • 5-Bromo-4-fluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyri dine
    • 1-(Triisopropylsilyl)-4-fluoro-5-bromo-1H-pyrrolo[2,3-b]pyridine
    • 5-Bromo-4-fluoro-1-[tris(propan-2-yl)sil
    • 5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine
    • P11171
    • CS-B0519
    • 5-BROMO-4-FLUORO-1-[TRIS(1-METHYLETHYL)SILYL]-1H-PYRROLO[2,3-B]PYRIDINE
    • CS-13155
    • (5-bromo-4-fluoropyrrolo[2,3-b]pyridin-1-yl)-tri(propan-2-yl)silane
    • SCHEMBL1470626
    • DTXSID601151345
    • 685513-91-1
    • AKOS025395269
    • MDL： MFCD11616414
    • Inchi： 1S/C16H24BrFN2Si/c1-10(2)21(11(3)4,12(5)6)20-8-7-13-15(18)14(17)9-19-16(13)20/h7-12H,1-6H3
    • InChI Key： AIJAFOFKGPWSSO-UHFFFAOYSA-N
    • SMILES： BrC1=CN=C2C(=C1F)C=CN2[Si](C(C)C)(C(C)C)C(C)C

Computed Properties

  • Exact Mass: 370.08800
  • Monoisotopic Mass: 370.088
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 4
  • Complexity: 342
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 17.8

Experimental Properties

  • Density: 1.24
  • Boiling Point: 334.9°C at 760 mmHg
  • Flash Point: 156.3°C
  • Refractive Index: 1.54
  • PSA: 17.82000
  • LogP: 5.96150

5-bromo-4-fluoro-1-[tris(propan-2-yl)silyl]-1H-pyrrolo[2,3-b]pyridine Pricemore >>

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