• 1. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 2. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 5. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

1-Cyclopropyl-6-oxo-1,6-dihydropyridine-3-carboxylic Acid: A Comprehensive Overview

1-Cyclopropyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid (CAS No. 677762-57-1) is a compound of significant interest in the field of organic chemistry and pharmacology. This compound belongs to the class of dihydropyridines, which are well-known for their structural versatility and potential applications in drug discovery. The molecule features a cyclopropyl group attached to the dihydropyridine ring, along with a carboxylic acid moiety at the 3-position and a ketone group at the 6-position. These structural elements contribute to its unique chemical properties and biological activity.

Recent studies have highlighted the importance of dihydropyridine derivatives in various therapeutic areas, including cardiovascular diseases, neurodegenerative disorders, and cancer. The cyclopropyl substitution in this compound introduces steric hindrance and enhances the stability of the molecule, making it a promising candidate for further exploration. Researchers have also investigated the synthesis pathways of this compound, focusing on optimizing reaction conditions to achieve higher yields and purities.

The carboxylic acid group in 1-Cyclopropyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid plays a crucial role in its chemical reactivity. This functional group can undergo various transformations, such as esterification or amidation, to generate derivatives with enhanced bioavailability or target specificity. For instance, recent advancements in click chemistry have enabled the creation of bioconjugates that retain the core structure of this compound while improving its pharmacokinetic properties.

In terms of biological activity, this compound has shown potential as a modulator of ion channels, particularly voltage-gated calcium channels. Experimental data suggest that it may exert its effects through interactions with specific residues within the channel's transmembrane domains. Furthermore, computational modeling studies have provided insights into the molecular docking patterns of this compound, revealing key interactions that could be exploited for drug design.

The cyclopropyl group also imparts unique electronic properties to the molecule, influencing its ability to penetrate cellular membranes and interact with target proteins. Preclinical studies have demonstrated that this compound exhibits moderate cytotoxicity against certain cancer cell lines, suggesting its potential as an anticancer agent. However, further research is required to elucidate its mechanism of action and identify optimal dosing regimens.

From a synthetic perspective, the preparation of 1-Cyclopropyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid involves multi-step reactions that require precise control over reaction conditions. The use of transition metal catalysts has been explored to facilitate key transformations, such as cyclopropanation or oxidation steps. These advancements have not only improved synthetic efficiency but also opened avenues for scaling up production for preclinical testing.

Looking ahead, the development of this compound into a clinically relevant drug will depend on several factors, including its pharmacokinetic profile, safety profile, and efficacy in animal models. Collaborative efforts between academic researchers and pharmaceutical companies are essential to overcoming these challenges and translating laboratory findings into real-world applications.

• 939411-29-7(1-Neopentyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 1041605-13-3(1-(2-Hydroxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 677762-39-9(1,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 3719-45-7(1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 939411-65-1(1,6-Dihydro-1-(3-methylcyclohexyl)-6-oxo-3-Pyridinecarboxylic acid)
• 846551-86-8(1-Cyclohexyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 933696-86-7(3-Pyridinecarboxylic acid, 1-cyclopentyl-1,6-dihydro-6-oxo-)
• 677762-00-4(1-Ethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 677762-07-1(6-oxo-1-(propan-2-yl)-1,6-dihydropyridine-3-carboxylic acid)
• 939411-30-0(1-(2-Methylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid)