• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 4. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 5. An integrated droplet-digital microfluidic system for on-demand droplet creation, mixing, incubation, and sorting?
  Lab Chip, 2019,19, 524-535

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids

6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid: A Comprehensive Overview

The compound with CAS No 677762-07-1, known as 6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid, is a significant molecule in the field of organic chemistry and pharmacology. This compound belongs to the class of dihydropyridines, which are widely studied for their diverse biological activities and potential applications in drug development. The dihydropyridine core of this molecule is particularly interesting due to its structural flexibility and ability to interact with various biological targets.

Recent studies have highlighted the antioxidant properties of 6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid, making it a promising candidate for applications in oxidative stress-related diseases. Researchers have demonstrated that this compound can effectively scavenge free radicals and reduce oxidative damage in cellular models, suggesting its potential as a therapeutic agent in conditions such as neurodegenerative disorders and cardiovascular diseases.

In addition to its antioxidant activity, this compound has shown anti-inflammatory effects in preclinical studies. The ability of 6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid to inhibit pro-inflammatory cytokines and modulate immune responses has drawn attention from researchers exploring new strategies for treating inflammatory diseases such as arthritis and inflammatory bowel disease.

The synthesis of 6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid involves a multi-step process that typically includes the preparation of the dihydropyridine ring followed by oxidation and functionalization steps. Recent advancements in synthetic chemistry have enabled more efficient and scalable methods for producing this compound, which is crucial for its potential large-scale use in pharmaceutical applications.

Moreover, computational studies have provided insights into the molecular mechanisms underlying the biological activities of this compound. Molecular docking studies have revealed that 6-Oxo-1-(Propan-2-yl)-1,6-Dihydropyridine-3-Carboxylic Acid interacts with key protein targets involved in oxidative stress and inflammation, further supporting its therapeutic potential.

Looking ahead, the development of derivatives of 6-Oxo-1-(Propan-2-y l)-1,6-Dihydro pyridine -3-Carbox ylic Acid is an active area of research aimed at enhancing its bioavailability and efficacy. These efforts are expected to pave the way for novel drug candidates with improved pharmacokinetic profiles and therapeutic outcomes.

In conclusion, 6-Oxo -1 -(Propan -2 -yl ) -1 , 6 -Dihydro py ridine -3 -Carbox ylic Acid represents a valuable molecule with significant potential in the fields of pharmacology and drug discovery. Its unique chemical structure, coupled with its diverse biological activities, positions it as a key player in the development of new therapeutic agents for various diseases.

• 138042-14-5(3-Pyridinecarboxylic acid, 1,6-dihydro-6-oxo-1-(2-propenyl)-, methylester)
• 939411-29-7(1-Neopentyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 1041605-13-3(1-(2-Hydroxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 677762-57-1(1-Cyclopropyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 3719-45-7(1-Methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 846551-86-8(1-Cyclohexyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 15889-88-0(4-Oxo-4H-quinolizine-1-carboxylic acid)
• 677762-00-4(1-Ethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 939411-30-0(1-(2-Methylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxylic acid)
• 24903-83-1(3-Pyridinecarboxylicacid, 1,6-dihydro-1-(1-methylethyl)-6-oxo-, ethyl ester)