Cas no 666839-74-3 (Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)-)
Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)- is a heterocyclic compound featuring a pyrimidine core substituted with chloro, fluoro, and piperazinyl functional groups. This structure imparts versatility in pharmaceutical and agrochemical applications, particularly as an intermediate in the synthesis of biologically active molecules. The presence of both chloro and fluoro substituents enhances reactivity and selectivity in nucleophilic substitution reactions, while the piperazinyl group contributes to improved solubility and binding affinity in target interactions. Its well-defined chemical properties make it a valuable building block for drug discovery, especially in the development of kinase inhibitors and antimicrobial agents. The compound is typically handled under controlled conditions due to its sensitivity to moisture and light.
666839-74-3 structure
Product Name:Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)-
CAS No:666839-74-3
MF:C8H10ClFN4
MW:216.643203258514
CID:501038
PubChem ID:53393355
Update Time:2025-06-09
Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)- Chemical and Physical Properties
Names and Identifiers
-
- Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)-
- 2-chloro-5-fluoro-4-piperazin-1-ylpyrimidine
- 666839-74-3
- AKOS015904321
- DTXSID20693872
- 2-CHLORO-5-FLUORO-4-(PIPERAZIN-1-YL)PYRIMIDINE
- A835521
- 2-Chloro-5-fluoro-4-(1-piperazinyl)-pyrimidine
-
- Inchi： 1S/C8H10ClFN4/c9-8-12-5-6(10)7(13-8)14-3-1-11-2-4-14/h5,11H,1-4H2
- InChI Key： XWTZBZZMKAJSSV-UHFFFAOYSA-N
- SMILES： ClC1=NC=C(C(=N1)N1CCNCC1)F
Computed Properties
- Exact Mass: 216.058
- Monoisotopic Mass: 216.058
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 14
- Rotatable Bond Count: 1
- Complexity: 188
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 1.1
- Topological Polar Surface Area: 41?2
Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)- Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Chemenu | CM523674-1g |
2-Chloro-5-fluoro-4-(piperazin-1-yl)pyrimidine |
666839-74-3 | 97% | 1g |
$320 | 2023-02-02 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1639468-1g |
2-Chloro-5-fluoro-4-(piperazin-1-yl)pyrimidine |
666839-74-3 | 98% | 1g |
￥4358.00 | 2024-05-04 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1639468-5g |
2-Chloro-5-fluoro-4-(piperazin-1-yl)pyrimidine |
666839-74-3 | 98% | 5g |
￥13259.00 | 2024-05-04 | |
| Ambeed | A846346-1g |
2-Chloro-5-fluoro-4-(piperazin-1-yl)pyrimidine |
666839-74-3 | 97% | 1g |
$323.0 | 2025-04-17 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | BB12-1223-5g |
2-chloro-5-fluoro-4-piperazinopyrimidine |
666839-74-3 | nan | 5g |
￥7581.60 | 2025-04-13 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | BB12-1223-10g |
2-chloro-5-fluoro-4-piperazinopyrimidine |
666839-74-3 | nan | 10g |
￥9266.40 | 2025-04-13 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | BB12-1223-25g |
2-chloro-5-fluoro-4-piperazinopyrimidine |
666839-74-3 | nan | 25g |
￥17901.00 | 2025-04-13 | |
| SHANG HAI SHAO YUAN SHI JI Co., Ltd. | BB12-1223-50g |
2-chloro-5-fluoro-4-piperazinopyrimidine |
666839-74-3 | nan | 50g |
￥29484.00 | 2025-04-13 |
Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)- Related Literature
-
Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
-
Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
-
Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
-
Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
666839-74-3 (Pyrimidine,2-chloro-5-fluoro-4-(1-piperazinyl)-) Related Products
- 749898-92-8(Pyrimidine,2-chloro-4-(4-methyl-1-piperazinyl)-)
- 16255-90-6(2-(2-Chloro-5-fluoropyrimidin-4-yl)aminoethanol)
- 40423-82-3(2-chloro-5-fluoro-4-(1-piperidyl)pyrimidine)
- 174728-03-1(2-Chloro-4-(piperazin-1-yl)pyrimidine)
- 477592-83-9(4-PYRIMIDINAMINE, 2-CHLORO-5-FLUORO-N-2-PROPYNYL-)
- 923119-59-9(2-Chloro-5-fluoro-4-(pyrrolidin-1-yl)pyrimidine)
- 385390-91-0(2-Chloro-5-fluoro-4-(4-methylpiperazin-1-yl)pyrimidine)
- 321529-80-0(2-Chloro-N-ethyl-5-fluoropyrimidin-4-amine)
- 1420868-89-8(2-Chloro-4-(piperazin-1-yl)pyrimidine hydrochloride)
- 355829-23-1(2-Chloro-5-fluoro-N,N-dimethylpyrimidin-4-amine)
Recommended suppliers
Zhangzhou Sinobioway Peptide Co.,Ltd.
Gold Member
Audited Supplier
CN Supplier
Reagent
Essenoi Fine Chemical Co., Limited
Gold Member
Audited Supplier
CN Supplier
Reagent
Hangzhou Cedareal Technology Co., Ltd.
Gold Member
Audited Supplier
CN Supplier
Bulk
Nanjing Jubai Biopharm
Gold Member
Audited Supplier
CN Supplier
Bulk
Shanghai Jinhuan Chemical CO., LTD.
Gold Member
Audited Supplier
CN Supplier
Bulk
