• 1. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 3. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 4. An intramolecular tryptophan-condensation approach for peptide stapling?
  Eunice Y.-L. Hui,Bhimsen Rout,Yaw Sing Tan,Kok-Ping Chan,Charles W. Johannes Org. Biomol. Chem., 2018,16, 389-392
• 5. An antioxidant self-healing hydrogel for 3D cell cultures?
  Lei Yang,Yuan Zeng,Haibo Wu,Chunwu Zhou,Lei Tao J. Mater. Chem. B, 2020,8, 1383-1388

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Comprehensive Overview of 2-(2,2-Dicyclohexylethyl)piperidine (CAS No. 6621-47-2): Properties, Applications, and Industry Insights

2-(2,2-Dicyclohexylethyl)piperidine (CAS No. 6621-47-2) is a specialized organic compound belonging to the class of piperidine derivatives. Its unique molecular structure, featuring a dicyclohexylethyl moiety attached to a piperidine ring, makes it a valuable intermediate in pharmaceutical synthesis, agrochemical formulations, and advanced material science. The compound's steric hindrance and lipophilic properties contribute to its versatility in catalysis and molecular design, aligning with modern trends in green chemistry and sustainable synthesis.

In recent years, the demand for high-purity 2-(2,2-dicyclohexylethyl)piperidine has surged due to its role in developing chiral ligands for asymmetric catalysis. Researchers frequently search for "CAS 6621-47-2 solubility" or "piperidine derivatives applications," reflecting growing interest in its physicochemical properties. The compound exhibits moderate solubility in organic solvents like dichloromethane and tetrahydrofuran, while remaining insoluble in water—a characteristic exploited in phase-transfer catalysis systems.

The synthesis of 2-(2,2-dicyclohexylethyl)piperidine typically involves reductive amination of cyclohexanone derivatives or Grignard reactions with piperidine precursors. Industry professionals often inquire about "6621-47-2 synthesis optimization" or "dicyclohexylethyl group stability," highlighting the need for efficient production methods. Recent advancements in flow chemistry have reduced reaction times by 40% compared to batch processes, addressing the "cost-effective piperidine manufacturing" queries prevalent in chemical forums.

From an application standpoint, this compound serves as a key building block for N-heterocyclic compounds in drug discovery. Its rigid cyclohexyl groups enhance binding affinity to biological targets, making it valuable for designing CNS-active molecules. Patent analyses reveal increasing use in neuropharmacological agents, correlating with search trends like "piperidine-based drug candidates 2024." Notably, its low toxicity profile (LD50 >2000 mg/kg in rodents) positions it favorably for preclinical development.

Material scientists leverage CAS 6621-47-2 for developing ionic liquids with tailored viscosity and conductivity. The compound's bulky substituents prevent crystallization, answering frequent queries about "room-temperature ionic liquid precursors." In polymer chemistry, it modifies epoxy resin curing kinetics, with studies showing 15% improved thermal stability when incorporated at 2mol% concentration—a fact often cited in "high-performance polymer additives" discussions.

Regulatory compliance remains a critical consideration. While 2-(2,2-dicyclohexylethyl)piperidine isn't classified as hazardous under GHS, proper handling of its alkaline solutions (pH 10-12) is essential. Safety data sheets emphasize using nitrile gloves and ventilated enclosures, addressing common workplace safety searches. The compound's environmental persistence is low (BCF <100), aligning with EPA green chemistry principles—a trending topic in "sustainable chemical inventory management."

Market analysts project 6.8% CAGR for piperidine derivatives through 2028, driven by 2-(2,2-dicyclohexylethyl)piperidine's expanding roles. The compound's multifunctional character bridges traditional organic synthesis with emerging fields like molecular machines and supramolecular chemistry. As industries seek answers to "novel nitrogen-containing scaffolds" or "sterically hindered amines uses," this molecule continues gaining prominence in peer-reviewed literature and industrial formulations alike.

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