• 1. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 2. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 3. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 4. Exciplex emission from the mixed dimer of naphthalene and 2-cyanonaphthalene in a supersonic jet
  Aloke Das,K. K. Mahato,Chayan K. Nandi,Tapas Chakraborty,Shridhar R. Gadre,Nikhil A. Gokhale Phys. Chem. Chem. Phys., 2002,4, 2162-2168
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

Comprehensive Guide to 4-Methoxy-N,6-dimethylpyrimidin-2-amine (CAS No. 66131-76-8): Properties, Applications, and Market Insights

4-Methoxy-N,6-dimethylpyrimidin-2-amine (CAS No. 66131-76-8) is a specialized organic compound belonging to the pyrimidine family. This heterocyclic amine is gaining attention in pharmaceutical and agrochemical research due to its unique structural properties. With the growing demand for pyrimidine derivatives in drug discovery, understanding this compound's characteristics becomes increasingly valuable for researchers and industry professionals.

The molecular structure of 4-methoxy-N,6-dimethylpyrimidin-2-amine features a pyrimidine core substituted with methoxy and dimethylamino groups at specific positions. This configuration contributes to its moderate polarity and influences its solubility profile, making it soluble in common organic solvents like ethanol and acetone but less so in water. Recent studies highlight its potential as a building block for pharmaceutical intermediates, particularly in developing novel therapeutic agents.

In pharmaceutical applications, 4-methoxy-N,6-dimethylpyrimidin-2-amine serves as a crucial precursor in synthesizing various bioactive molecules. Researchers are particularly interested in its role in creating kinase inhibitors, a hot topic in cancer research. The compound's ability to modulate enzyme activity makes it valuable for developing treatments targeting specific cellular pathways, aligning with current trends in personalized medicine and targeted therapy approaches.

The agrochemical industry has also shown interest in pyrimidine-based compounds like 4-methoxy-N,6-dimethylpyrimidin-2-amine. Its structural features make it a potential candidate for developing new-generation crop protection agents. With increasing global focus on sustainable agriculture and reduced environmental impact, this compound's derivatives may contribute to creating more selective and eco-friendly pesticides.

From a synthetic chemistry perspective, 4-methoxy-N,6-dimethylpyrimidin-2-amine offers several advantages. Its relatively stable nature under standard conditions makes it convenient for laboratory handling and storage. The compound typically appears as a white to off-white crystalline powder with characteristic physical properties that facilitate its identification and quality control in industrial settings.

Market analysis indicates growing demand for specialty pyrimidine derivatives like 4-methoxy-N,6-dimethylpyrimidin-2-amine. The global market for fine chemicals used in pharmaceutical research continues to expand, driven by increased R&D investment and the need for novel therapeutic compounds. Suppliers specializing in heterocyclic building blocks are reporting steady growth in inquiries for this specific compound.

Quality specifications for 4-methoxy-N,6-dimethylpyrimidin-2-amine typically include purity assessments through HPLC analysis, moisture content determination, and residual solvent testing. Reputable manufacturers provide detailed certificates of analysis (CoA) to ensure compliance with industry standards. Current Good Manufacturing Practice (cGMP) compliant versions are becoming increasingly available to meet pharmaceutical industry requirements.

Environmental and safety considerations for handling 4-methoxy-N,6-dimethylpyrimidin-2-amine follow standard laboratory protocols. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and safety glasses is recommended when working with this compound. Storage conditions typically suggest keeping the material in a cool, dry place away from strong oxidizers.

Recent patent literature reveals growing interest in applications of 4-methoxy-N,6-dimethylpyrimidin-2-amine derivatives. Several filings describe its incorporation into novel drug candidates targeting inflammatory diseases and metabolic disorders. This aligns with current pharmaceutical trends addressing chronic conditions in aging populations, making this compound particularly relevant to modern therapeutic development.

Analytical characterization of 4-methoxy-N,6-dimethylpyrimidin-2-amine typically employs techniques such as NMR spectroscopy, mass spectrometry, and infrared spectroscopy. These methods confirm structural identity and purity, crucial for research applications where precise molecular composition is essential. Advanced users often employ X-ray crystallography to study its solid-state properties.

The stability profile of 4-methoxy-N,6-dimethylpyrimidin-2-amine has been investigated under various conditions. Results indicate good thermal stability at room temperature, with decomposition observed only at elevated temperatures. This characteristic makes it suitable for various synthetic transformations without significant degradation concerns under typical reaction conditions.

Supply chain dynamics for pyrimidine derivatives like 4-methoxy-N,6-dimethylpyrimidin-2-amine have evolved in recent years. While traditionally produced in specialized facilities, more manufacturers are now offering this compound in both research and bulk quantities. The development of efficient synthetic routes has improved availability while maintaining competitive pricing in the fine chemicals market.

Future research directions for 4-methoxy-N,6-dimethylpyrimidin-2-amine include exploring its potential in materials science applications. The compound's electronic properties make it interesting for developing organic semiconductors or as a component in advanced material formulations. Such applications could open new market opportunities beyond its current pharmaceutical and agrochemical uses.

For researchers sourcing 4-methoxy-N,6-dimethylpyrimidin-2-amine, verification of supplier credentials and quality documentation is essential. Reputable suppliers provide comprehensive technical data sheets and support analytical needs for specific applications. The compound is increasingly available through both traditional chemical distributors and specialized fine chemical providers.

In conclusion, 4-methoxy-N,6-dimethylpyrimidin-2-amine (CAS No. 66131-76-8) represents an important pyrimidine derivative with growing significance in multiple industries. Its versatile applications in pharmaceutical research and potential in agrochemical development position it as a valuable compound in modern chemical innovation. As research continues to uncover new applications, the importance of this specialized chemical building block is likely to increase in coming years.

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