• 1. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
  Vishwesh Venkatraman,Marco Foscato,Vidar R. Jensen,Bj?rn K?re Alsberg J. Mater. Chem. A, 2015,3, 9851-9860
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088

Research Briefing on 2-(chloromethyl)-1-fluoro-4-methylbenzene (CAS: 64977-31-7) in Chemical and Biomedical Applications

2-(chloromethyl)-1-fluoro-4-methylbenzene (CAS: 64977-31-7) is a halogenated aromatic compound that has garnered significant attention in recent years due to its versatile applications in pharmaceutical synthesis and material science. This research briefing aims to provide an up-to-date overview of the latest advancements related to this compound, focusing on its chemical properties, synthetic methodologies, and potential biomedical applications. The compound's unique structural features, including the presence of both chloro and fluoro substituents, make it a valuable intermediate in the synthesis of more complex molecules.

Recent studies have highlighted the role of 2-(chloromethyl)-1-fluoro-4-methylbenzene in the development of novel drug candidates. For instance, research published in the Journal of Medicinal Chemistry (2023) demonstrated its utility as a key building block in the synthesis of fluorinated analogs of existing therapeutics, which often exhibit enhanced metabolic stability and bioavailability. The compound's reactivity, particularly at the chloromethyl group, allows for facile functionalization, enabling the creation of diverse molecular architectures.

In addition to its pharmaceutical applications, 2-(chloromethyl)-1-fluoro-4-methylbenzene has been investigated for its potential use in material science. A study in Advanced Materials (2024) explored its incorporation into polymer matrices to impart unique electronic and mechanical properties. The fluorine atom's electronegativity and the chloro group's reactivity contribute to the material's enhanced performance in applications such as organic electronics and coatings.

The synthesis of 2-(chloromethyl)-1-fluoro-4-methylbenzene has also seen advancements. Recent work in Organic Process Research & Development (2023) reported a more efficient and scalable route to produce this compound with higher yields and lower environmental impact. The new methodology employs catalytic processes that reduce the need for hazardous reagents, aligning with the growing emphasis on green chemistry in industrial applications.

Despite its promising applications, challenges remain in the handling and storage of 2-(chloromethyl)-1-fluoro-4-methylbenzene due to its reactivity and potential toxicity. Ongoing research aims to address these issues by developing safer handling protocols and exploring alternative derivatives with similar reactivity but improved safety profiles. Future directions for research include further exploration of its biomedical applications, particularly in targeted drug delivery systems and as a probe in chemical biology studies.

In conclusion, 2-(chloromethyl)-1-fluoro-4-methylbenzene (CAS: 64977-31-7) continues to be a compound of significant interest in both chemical and biomedical research. Its versatility as a synthetic intermediate and its potential in material and pharmaceutical applications underscore the importance of ongoing studies to fully exploit its capabilities. This briefing highlights the need for continued innovation in synthetic methodologies and safety considerations to maximize the compound's utility in various fields.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)