Cas no 649-15-0 (N,N-Diethyl-p-toluenesulfonamide)

N,N-Diethyl-p-toluenesulfonamide is a sulfonamide derivative characterized by its toluenesulfonyl backbone and diethylamino substituents. This compound is commonly utilized as an intermediate in organic synthesis, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty chemicals. Its key advantages include high stability under a range of reaction conditions and compatibility with various solvents, making it a versatile reagent. The presence of the electron-withdrawing sulfonamide group enhances its reactivity in nucleophilic substitution and condensation reactions. Additionally, its well-defined structure and purity ensure consistent performance in synthetic applications. The compound is typically handled under standard laboratory conditions, with appropriate precautions for sulfonamide derivatives.
N,N-Diethyl-p-toluenesulfonamide structure
649-15-0 structure
Product Name:N,N-Diethyl-p-toluenesulfonamide
CAS No:649-15-0
MF:C11H17NO2S
MW:227.323181867599
MDL:MFCD00059369
CID:508988
PubChem ID:87576261
Update Time:2025-06-07

N,N-Diethyl-p-toluenesulfonamide Chemical and Physical Properties

Names and Identifiers

    • N,N-Diethyl-4-methylbenzenesulfonamide
    • N,N-Diethyl-p-toluenesulfonamide
    • Benzenesulfonamide,N,N-diethyl-4-methyl-
    • p-Toluenesulfonyl-N,N-diethylamide
    • p-Toluenesulfonamide, N,N-diethyl-
    • Benzenesulfonamide, N,N-diethyl-4-methyl-
    • p-Toluenesulfonyl-N-diethylamide
    • NSC22501
    • n,n-diethyl-4-methylbenzolsulfonamid
    • Maybridge1_002134
    • Cambridge id 5116375
    • CBDivE_015189
    • p-Toluenesulfonamide,N-diethyl-
    • N,N-Dirthyl-P-toluenesulfonamide
    • Toluenesulf
    • Benzenesulfonamide, 4-methyl-N,N-diethyl-
    • PJP
    • AE-641/00674038
    • CS-0020189
    • AOJBACHWNDMRQP-UHFFFAOYSA-
    • N,N-diethyl-4-methylbenzenesulonamide
    • N,N-Diethyl-4-methylbenzenesulfonamide; 4-Methyl-N,N-diethylbenzenesulfonamide; N,N-Diethyl-p-toluenesulfonamide; NSC 22501
    • AOJBACHWNDMRQP-UHFFFAOYSA-N
    • CHEBI:195017
    • HMS547I22
    • AS-63654
    • EU-0000082
    • 649-15-0
    • NSC-22501
    • Benzenesulfonamide,N-diethyl-4-methyl-
    • N1,N1-diethyl-4-methylbenzene-1-sulfonamide
    • MFCD00059369
    • T0285
    • SR-01000389095
    • SR-01000389095-1
    • N,N-diethyl-4-methylbenzene-1-sulfonamide
    • SB79601
    • Z45516134
    • BRN 2214537
    • AKOS002286012
    • NSC 22501
    • AI3-01084
    • DTXSID30215221
    • InChI=1/C11H17NO2S/c1-4-12(5-2)15(13,14)11-8-6-10(3)7-9-11/h6-9H,4-5H2,1-3H3
    • EN300-7408208
    • SCHEMBL5023540
    • N,N-diethyl-4-methyl-benzenesulfonamide
    • D95378
    • MDL： MFCD00059369
    • Inchi： 1S/C11H17NO2S/c1-4-12(5-2)15(13,14)11-8-6-10(3)7-9-11/h6-9H,4-5H2,1-3H3
    • InChI Key： AOJBACHWNDMRQP-UHFFFAOYSA-N
    • SMILES： S(C1C=CC(C)=CC=1)(N(CC)CC)(=O)=O
    • BRN： 2214537

Computed Properties

  • Exact Mass: 227.09800
  • Monoisotopic Mass: 227.098
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 4
  • Complexity: 270
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2.2
  • Topological Polar Surface Area: 45.8

Experimental Properties

  • Color/Form: 。
  • Density: 1.112
  • Melting Point: 57.0 to 61.0 deg-C
  • Boiling Point: 328.7°C at 760 mmHg
  • Flash Point: 152.6°C
  • Refractive Index: 1.524
  • PSA: 45.76000
  • LogP: 3.10630
  • Solubility: 。

N,N-Diethyl-p-toluenesulfonamide Security Information

  • RTECS：XT5619800

N,N-Diethyl-p-toluenesulfonamide Customs Data

  • HS CODE：2935009090
  • Customs Data：

    China Customs Code:

    2935009090

    Overview:

    2935009090 Other sulphonates(Acyl)amine. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:35.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

N,N-Diethyl-p-toluenesulfonamide Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
TRC
D442075-500mg
N,N-Diethyl-p-toluenesulfonamide
 649-15-0
500mg
 $178.00 2023-05-18
TRC
D442075-1g
N,N-Diethyl-p-toluenesulfonamide
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 $ 265.00 2022-06-05
TRC
D442075-2.5g
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 $758.00 2023-05-18
TRC
D442075-5g
N,N-Diethyl-p-toluenesulfonamide
 649-15-0
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 $ 800.00 2023-09-07
Alichem
A019087994-500g
N,N-Diethyl-4-methylbenzenesulfonamide
 649-15-0 95%
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TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.
T0285-25G
N,N-Diethyl-p-toluenesulfonamide
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 ￥660.00 2024-04-16
abcr
AB142646-25 g
p-Toluenesulfonyl-N,N-diethylamide, 98%; .
 649-15-0 98%
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 €101.70 2023-05-09
SHANG HAI XIAN DING Biotechnology Co., Ltd.
T0285-25g
N,N-Diethyl-p-toluenesulfonamide
 649-15-0 98.0%(LC&N)
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 ￥730.0 2022-06-10
A FA AI SHA ， SAI MO FEI SHI ER KE JI QI XIA GONG SI
H55053-1g
N,N-Diethyl-4-methylbenzenesulfonamide, 97%
 649-15-0 97%
1g
 ￥1146.00 2023-02-09
A FA AI SHA ， SAI MO FEI SHI ER KE JI QI XIA GONG SI
H55053-5g
N,N-Diethyl-4-methylbenzenesulfonamide, 97%
 649-15-0 97%
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 ￥4600.00 2023-02-09

N,N-Diethyl-p-toluenesulfonamide Production Method

Production Method 1

Reaction Conditions
1.1 Solvents: Toluene ;  48 h, 110 °C
Reference
TiCl4-mediated direct N-alkylation of sulfonamides with inactive ethers
Chen, Jiayan; et al, Synlett, 2012, 23(4), 595-600

N,N-Diethyl-p-toluenesulfonamide Raw materials

N,N-Diethyl-p-toluenesulfonamide Preparation Products

N,N-Diethyl-p-toluenesulfonamide Related Literature

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