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• 2. A design strategy of bipolar host materials for more than 30 times extended lifetime in phosphorescent organic light-emitting diodes using benzocarbazole and quinazoline
  Sung Moo Kim,Ju Hui Yun,Si Hyun Han,Jun Yeob Lee J. Mater. Chem. C 2017 5 9072
• 3. A design strategy of bipolar host materials for more than 30 times extended lifetime in phosphorescent organic light-emitting diodes using benzocarbazole and quinazoline
  Sung Moo Kim,Ju Hui Yun,Si Hyun Han,Jun Yeob Lee J. Mater. Chem. C 2017 5 9072
• 4. Ring transformations involving chloroheterocycles. Part III. Reaction of 4-chloroquinazolines with hydrazines
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Quinazolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolines

Comprehensive Overview of 4-Chloro-2-phenylquinazoline (CAS No. 6484-25-9): Properties, Applications, and Research Insights

4-Chloro-2-phenylquinazoline (CAS No. 6484-25-9) is a heterocyclic organic compound belonging to the quinazoline family, a class of nitrogen-containing bicyclic structures widely studied for their diverse chemical and pharmacological properties. This compound features a chlorine substituent at the 4-position and a phenyl group at the 2-position of the quinazoline core, which significantly influences its reactivity and potential applications. Researchers and industries are increasingly interested in this molecule due to its role as a versatile building block in medicinal chemistry, material science, and agrochemical development.

The structural uniqueness of 4-Chloro-2-phenylquinazoline makes it a valuable intermediate in synthesizing more complex molecules. Its electron-deficient quinazoline ring and chloro-substituent enable nucleophilic substitution reactions, facilitating the creation of derivatives with tailored properties. Recent studies highlight its utility in designing kinase inhibitors, a hot topic in drug discovery for targeting cancers and inflammatory diseases. The compound’s aromatic system also contributes to its potential in optoelectronic materials, aligning with the growing demand for organic semiconductors in flexible electronics and OLED technologies.

In the context of green chemistry, researchers are exploring sustainable synthetic routes for 4-Chloro-2-phenylquinazoline to minimize environmental impact. Questions like "How to optimize the yield of 4-Chloro-2-phenylquinazoline?" or "What are the alternatives to toxic solvents in its synthesis?" reflect current trends in laboratory practices. Analytical techniques such as HPLC, NMR, and mass spectrometry are critical for characterizing this compound, ensuring purity for downstream applications. These methodologies address common search queries like "CAS 6484-25-9 analysis methods" or "quinazoline derivative purification protocols."

The compound’s stability under various conditions is another area of interest. Users often search for "storage recommendations for 4-Chloro-2-phenylquinazoline" or "compatibility with common reagents." Proper handling in anhydrous environments and protection from light are advised to maintain its integrity. Additionally, its solubility profile—moderate in polar organic solvents like DMSO but poor in water—guides formulation strategies in pharmaceutical research.

Beyond laboratories, 4-Chloro-2-phenylquinazoline has garnered attention in patent literature for its inclusion in novel antimicrobial agents and anticancer scaffolds. This aligns with the surge in public interest around drug-resistant infections and personalized medicine. Discussions on platforms like ResearchGate often focus on its mechanistic interactions with biological targets, addressing queries such as "How does 4-Chloro-2-phenylquinazoline inhibit enzyme activity?" or "What are its structure-activity relationships?"

In summary, 4-Chloro-2-phenylquinazoline (CAS No. 6484-25-9) exemplifies the intersection of fundamental chemistry and applied science. Its adaptability in molecular design, coupled with ongoing advancements in synthetic and analytical techniques, ensures its relevance in addressing contemporary challenges across multiple disciplines. As innovation continues, this compound will likely remain a focal point for both academic and industrial research.

• 59490-96-9(Quinazoline, 4-chloro-2-(4-methylphenyl)-)
• 144924-32-3(Quinazoline,4,6-dichloro-2-(4-chlorophenyl)-)
• 885277-13-4(Quinazoline,4-chloro-5-methyl-2-phenyl-)
• 885277-69-0(Quinazoline,4-chloro-2-(4-chlorophenyl)-6-methyl-)
• 59490-94-7(4-chloro-2-(4-chlorophenyl)quinazoline)
• 885277-72-5(4,7-Dichloro-2-(4-Chlorophenyl)Quinazoline)
• 885277-09-8(4-Chloro-6-fluoro-2-phenylquinazoline)
• 29083-98-5(Quinazoline,4-chloro-6-methyl-2-phenyl-)
• 62220-44-4(Quinazoline, 4-chloro-2-(3,4-dichlorophenyl)-)
• 83800-98-0(2-(4-bromophenyl)-4-chloroquinazoline)