• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Fc microparticles can modulate the physical extent and magnitude of complement activity?
  David White,Sean R. Stowell Biomater. Sci., 2017,5, 463-474

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Phenylpropanes

2-(3-Chlorophenyl)-2-methylpropanoic Acid (CAS No. 64798-35-2): Properties, Applications, and Market Insights

2-(3-Chlorophenyl)-2-methylpropanoic acid (CAS No. 64798-35-2) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This white crystalline powder belongs to the class of arylpropionic acid derivatives, a group known for its diverse biological activities and industrial applications. With the growing interest in chiral compounds and pharmaceutical intermediates, this chemical has become increasingly relevant in modern synthetic chemistry.

The molecular structure of 2-(3-Chlorophenyl)-2-methylpropanoic acid features a chlorophenyl group attached to a branched carboxylic acid moiety, giving it unique physicochemical properties. It has a molecular weight of 198.65 g/mol and typically appears as fine crystals with a melting point range of 120-125°C. The presence of both aromatic and aliphatic components in its structure makes it particularly interesting for researchers exploring structure-activity relationships in drug development.

In pharmaceutical applications, 2-(3-Chlorophenyl)-2-methylpropanoic acid serves as a valuable building block for the synthesis of various active pharmaceutical ingredients (APIs). Its structural features make it particularly useful in creating non-steroidal anti-inflammatory drugs (NSAIDs) analogs, where researchers are investigating novel compounds with improved efficacy and reduced side effects. The compound's chiral center also makes it relevant for studies in asymmetric synthesis, a hot topic in modern medicinal chemistry.

Recent trends in green chemistry have spurred interest in more sustainable production methods for compounds like 2-(3-Chlorophenyl)-2-methylpropanoic acid. Researchers are exploring catalytic processes and biocatalytic routes to synthesize this intermediate with higher atom economy and lower environmental impact. These developments align with the pharmaceutical industry's push toward sustainable manufacturing practices, addressing common search queries about eco-friendly chemical synthesis.

The global market for 2-(3-Chlorophenyl)-2-methylpropanoic acid has shown steady growth, driven by increasing demand from the pharmaceutical sector and contract research organizations. Market analysts note particular interest from regions with strong generic drug manufacturing capabilities, as this intermediate finds use in various therapeutic categories. Quality standards for this compound typically require high purity levels (>98%), with strict control of residual solvents and heavy metal content to meet pharmaceutical-grade specifications.

Analytical characterization of 2-(3-Chlorophenyl)-2-methylpropanoic acid typically involves techniques such as HPLC analysis, mass spectrometry, and NMR spectroscopy. These methods are crucial for verifying identity, purity, and stability - key concerns for researchers who frequently search for compound characterization methods. The compound shows good stability under standard storage conditions (room temperature, protected from moisture), though prolonged exposure to strong light or extreme temperatures should be avoided.

In research applications, 2-(3-Chlorophenyl)-2-methylpropanoic acid has been investigated for its potential in creating molecular probes and bioconjugates. Its carboxylic acid functionality allows for straightforward derivatization, making it useful in chemical biology studies. This aligns with current scientific trends toward targeted drug delivery systems and precision medicine approaches, topics that generate significant search volume in scientific databases.

Safety considerations for handling 2-(3-Chlorophenyl)-2-methylpropanoic acid include standard laboratory precautions - wearing appropriate personal protective equipment and working in well-ventilated areas. While not classified as highly hazardous, proper handling procedures should be followed, as with all fine chemicals. These safety aspects are frequently searched by laboratory professionals and students new to working with organic compounds.

The synthesis of 2-(3-Chlorophenyl)-2-methylpropanoic acid typically involves Friedel-Crafts acylation followed by various functional group transformations. Recent patent literature reveals ongoing optimization of these synthetic routes, particularly focusing on improving yield and stereoselectivity. Process chemists often search for alternative synthetic pathways to such intermediates, reflecting the compound's industrial importance.

Looking forward, 2-(3-Chlorophenyl)-2-methylpropanoic acid is expected to maintain its relevance in pharmaceutical research, particularly as interest grows in structural analogs of established drugs. The compound's versatility as a synthetic intermediate positions it well for future applications in drug discovery and medicinal chemistry programs. Its role in developing potential treatments for inflammatory conditions continues to be an area of active investigation, connecting to widespread public interest in new therapeutic options for chronic diseases.

• 21771-88-0(2-(4-chlorophenyl)-2-phenylacetic acid)
• 6258-30-6(4-Chloro-α,α-dimethylphenylacetic acid)
• 938-95-4(2-(4-Chlorophenyl)propanoic acid)
• 75852-57-2([1,1'-Biphenyl]-3-aceticacid, 5-chloro-a-methyl-)
• 118459-48-6(2-(4-Chlorophenyl)malonic acid)
• 88875-60-9(2-(3,4-Dichlorophenyl)-2-Phenylacetic Acid)
• 83-05-6(Bis(4-chlorophenyl)acetic Acid)
• 75852-59-4([1,1'-Biphenyl]-3-aceticacid, 4',5-dichloro-a-methyl-)
• 14161-84-3(2-(3-Chlorophenyl)propanoic acid)
• 64047-34-3(Benzeneacetic acid,ar-chloro-a-(chlorophenyl)-, sodium salt(9CI))