• 1. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 2. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 3. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
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• 4. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
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• 5. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives

2-Ethoxy-5-Methylbenzoyl Chloride (CAS No. 64507-09-1): A Comprehensive Overview

2-Ethoxy-5-methylbenzoyl chloride (CAS No. 64507-09-1) is a versatile organic compound that plays a significant role in various chemical and pharmaceutical applications. This compound, also known as 2-ethoxy-5-methylbenzoyl chloride, is characterized by its unique chemical structure and reactivity, making it an essential reagent in synthetic chemistry and drug development.

The molecular formula of 2-ethoxy-5-methylbenzoyl chloride is C₁₀H₁₁ClO₂, and it has a molecular weight of approximately 198.64 g/mol. The compound features a benzene ring substituted with an ethoxy group at the 2-position and a methyl group at the 5-position, with a chlorine atom attached to the carbonyl carbon. This specific arrangement of functional groups imparts unique chemical properties to the molecule, making it highly reactive in various chemical reactions.

In the realm of synthetic chemistry, 2-ethoxy-5-methylbenzoyl chloride is widely used as an acylating agent. Its reactivity with nucleophiles, such as alcohols, amines, and thiols, allows for the formation of esters, amides, and thioesters, respectively. This versatility makes it a valuable intermediate in the synthesis of complex organic molecules, including pharmaceuticals, agrochemicals, and fine chemicals.

Recent research has highlighted the potential of 2-ethoxy-5-methylbenzoyl chloride in the development of novel pharmaceuticals. For instance, a study published in the Journal of Medicinal Chemistry in 2023 explored the use of this compound in the synthesis of potent anti-inflammatory agents. The researchers found that derivatives of 2-ethoxy-5-methylbenzoyl chloride exhibited significant anti-inflammatory activity in both in vitro and in vivo models, suggesting its potential as a lead compound for further drug development.

In addition to its applications in drug discovery, 2-ethoxy-5-methylbenzoyl chloride has also been investigated for its use in polymer science. A study published in the Polymer Chemistry journal in 2022 demonstrated that this compound can be used as a monomer to synthesize functional polymers with tailored properties. These polymers have shown promise in applications such as drug delivery systems and coatings due to their biocompatibility and tunable degradation rates.

The safety and handling of 2-ethoxy-5-methylbenzoyl chloride are critical considerations for its use in laboratory settings. As with many organic chlorides, this compound is highly reactive and can release toxic fumes when exposed to moisture or heat. Therefore, it is essential to handle it under inert conditions and with appropriate personal protective equipment (PPE) to ensure safety.

In conclusion, 2-ethoxy-5-methylbenzoyl chloride (CAS No. 64507-09-1) is a multifaceted compound with a wide range of applications in synthetic chemistry, pharmaceutical development, and polymer science. Its unique chemical structure and reactivity make it an indispensable reagent for researchers and chemists working in these fields. Ongoing research continues to uncover new potential uses for this compound, further solidifying its importance in modern chemistry.

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