Cas no 64376-14-3 (2-Amino-6-methylpyrimidine-4-carbonitrile)

2-Amino-6-methylpyrimidine-4-carbonitrile is a heterocyclic organic compound featuring a pyrimidine core substituted with an amino group, a methyl group, and a nitrile functionality. This structure imparts versatility as a key intermediate in pharmaceutical and agrochemical synthesis. Its reactive sites enable further functionalization, making it valuable for constructing complex molecules. The compound exhibits stability under standard conditions, ensuring consistent performance in synthetic applications. Its high purity and well-defined chemical properties facilitate precise reactions, particularly in nucleophilic substitutions and cyclization processes. Researchers and industrial chemists utilize this compound for developing active ingredients, leveraging its robust scaffold for tailored molecular designs.
2-Amino-6-methylpyrimidine-4-carbonitrile structure
64376-14-3 structure
Product Name:2-Amino-6-methylpyrimidine-4-carbonitrile
CAS No:64376-14-3
MF:C6H6N4
MW:134.13863992691
CID:501045
PubChem ID:818454
Update Time:2025-10-29

2-Amino-6-methylpyrimidine-4-carbonitrile Chemical and Physical Properties

Names and Identifiers

    • 2-Amino-6-methylpyrimidine-4-carbonitrile
    • 2-AMINO-4-CYANO-6-METHYLPYRIMIDINE
    • 4-Pyrimidinecarbonitrile,2-amino-6-methyl-
    • 2-Amino-4-methyl-6-cyan-pyrimidin
    • 2-Amino-6-cyano-4-methylpyrimidin
    • 2-Amino-6-methyl-pyrimidin-4-carbonitril
    • 2-amino-6-methyl-pyrimidine-4-carbonitrile
    • AG-664/25005969
    • FT-0691540
    • 64376-14-3
    • DTXSID50355951
    • A834736
    • YXSNOFWJDHHMPD-UHFFFAOYSA-N
    • AKOS006241955
    • SB56005
    • 2-amino-6-cyano-4-methylpyrimidine
    • SCHEMBL10692686
    • DB-017507
    • Inchi： 1S/C6H6N4/c1-4-2-5(3-7)10-6(8)9-4/h2H,1H3,(H2,8,9,10)
    • InChI Key： YXSNOFWJDHHMPD-UHFFFAOYSA-N
    • SMILES： N1C(N)=NC(C#N)=CC=1C

Computed Properties

  • Exact Mass: 134.05900
  • Monoisotopic Mass: 134.059246208g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 0
  • Complexity: 158
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.3
  • Topological Polar Surface Area: 75.6?2

Experimental Properties

  • Density: 1.27
  • Boiling Point: 397.9 °C at 760 mmHg
  • Flash Point: 194.5 °C
  • Refractive Index: 1.582
  • PSA: 75.59000
  • LogP: 0.82008

2-Amino-6-methylpyrimidine-4-carbonitrile Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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2-Amino-6-methylpyrimidine-4-carbonitrile Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:64376-14-3)2-Amino-6-methylpyrimidine-4-carbonitrile
Order Number:A834736
Stock Status:in Stock
Quantity:1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 06:31
Price ($):380.0

2-Amino-6-methylpyrimidine-4-carbonitrile Related Literature

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Additional information on 2-Amino-6-methylpyrimidine-4-carbonitrile

Comprehensive Overview of 2-Amino-6-methylpyrimidine-4-carbonitrile (CAS No. 64376-14-3)

2-Amino-6-methylpyrimidine-4-carbonitrile (CAS No. 64376-14-3) is a versatile heterocyclic compound widely used in pharmaceutical and agrochemical research. This pyrimidine derivative is characterized by its amino and cyano functional groups, which make it a valuable intermediate in organic synthesis. Researchers frequently explore its applications in drug discovery, particularly in the development of kinase inhibitors and antimicrobial agents. The compound's molecular structure (C6H6N4) offers unique reactivity, enabling modifications for targeted biological activity.

In recent years, the demand for 2-Amino-6-methylpyrimidine-4-carbonitrile has surged due to its role in synthesizing small-molecule therapeutics. Its relevance in cancer research and central nervous system (CNS) drug development aligns with trending scientific inquiries, such as "how to design selective kinase inhibitors" or "novel pyrimidine-based antimicrobials." The compound's CAS No. 64376-14-3 is often searched alongside terms like "synthetic routes," "spectroscopic data," and "safety profiles," reflecting its technical importance.

From a synthetic chemistry perspective, 2-Amino-6-methylpyrimidine-4-carbonitrile serves as a precursor for multi-step reactions, including palladium-catalyzed cross-coupling and nucleophilic substitutions. Its nitrile group allows further functionalization, making it a staple in medicinal chemistry libraries. Analytical techniques like HPLC, NMR, and mass spectrometry are commonly employed to verify its purity, a topic frequently queried in academic forums.

Environmental and regulatory considerations are also critical. While not classified as hazardous, proper handling of 64376-14-3 is emphasized in laboratory safety guidelines. Users often search for "storage conditions" or "compatibility with solvents," underscoring the need for precise technical documentation. The compound's stability under various pH levels and temperatures is another area of interest, particularly for industrial-scale applications.

Innovations in green chemistry have spurred interest in sustainable synthesis methods for 2-Amino-6-methylpyrimidine-4-carbonitrile. Questions like "catalytic alternatives for pyrimidine synthesis" or "solvent-free reactions" dominate discussions in research communities. These advancements align with global trends toward eco-friendly manufacturing, further elevating the compound's profile.

In summary, 2-Amino-6-methylpyrimidine-4-carbonitrile (CAS No. 64376-14-3) remains a cornerstone in modern organic synthesis, bridging gaps between academia and industry. Its adaptability to high-throughput screening and structure-activity relationship (SAR) studies ensures its enduring relevance in solving complex biochemical challenges.

64376-14-3 (2-Amino-6-methylpyrimidine-4-carbonitrile) Related Products

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Amadis Chemical Company Limited
(CAS:64376-14-3)2-Amino-6-methylpyrimidine-4-carbonitrile
A834736
Purity:99%
Quantity:1g
Price ($):380.0
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