Production Method 1

897-06-3

638163-36-7

Reaction Conditions

1.1R:D2, C:RhCl(PPh3)3, S:C6D6, 1 h, rt
1.2S:C6D6, 10 min, rt
1.3R:D2, 1 h, rt
2.1R:NaOD, S:D2O, S:MeOD, 24 h, 65°C
2.2R:DCl, S:D2O, rt, pH 6-7
3.1R:NaBD4, S:4712-36-1, S:D2O, 2 h, 0°C
3.2R:AcOD, S:D2O, pH 6-7
4.1R:H2SO4, S:MeOH, 48 h, 55°C
4.2R:KOH, S:H2O, rt, pH 7-8

Reference

Syntheses of stable isotope-labeled 6β-hydroxycortisol, 6β-hydroxycortisone, and 6β-hydroxytestosterone

By Furuta, Takashi et al, Steroids, 2003, 68(7-8), 693-703

[2H4]-Testosterone Raw materials

• Androsta-1,4-diene-3,17-dione

[2H4]-Testosterone Preparation Products

• [2H4]-Testosterone (638163-36-7)

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