• 1. Synthetic studies on daphniglaucins
  Yuanyou Qiu,Jiaxin Zhong,Shan Du,Shuanhu Gao Chem. Commun. 2018 54 5554

Comprehensive Overview of Ethyl 2-(benzylamino)acetate Hydrochloride (CAS No. 6344-42-9)

Ethyl 2-(benzylamino)acetate Hydrochloride (CAS No. 6344-42-9) is a specialized organic compound widely utilized in pharmaceutical and chemical research. This hydrochloride salt derivative of ethyl 2-(benzylamino)acetate is recognized for its unique molecular structure, combining an ethyl ester group with a benzylamine moiety. Its chemical stability and solubility profile make it a valuable intermediate in synthetic chemistry, particularly in the development of bioactive molecules.

The compound's CAS number 6344-42-9 serves as a critical identifier in regulatory and commercial databases, ensuring precise tracking in supply chains. Researchers often explore its role in peptide synthesis and drug delivery systems, aligning with current trends in precision medicine and bioconjugation techniques. Recent studies highlight its potential in modulating enzyme activity, a topic gaining traction in AI-driven drug discovery platforms.

From a commercial perspective, Ethyl 2-(benzylamino)acetate Hydrochloride is frequently searched alongside terms like "high-purity chemical intermediates" and "non-toxic pharmaceutical excipients", reflecting industry demand for safer alternatives. Its low environmental impact aligns with the growing focus on green chemistry, a key concern for modern manufacturers. Analytical techniques such as HPLC and NMR spectroscopy are typically employed to verify its purity, addressing quality control questions commonly raised in research forums.

The compound's crystalline form and hygroscopic nature require specific storage conditions, a practical consideration often discussed in laboratory management circles. While not classified as hazardous, proper handling protocols are recommended to maintain its structural integrity—a detail frequently queried in chemical safety databases. Patent literature reveals innovative applications in controlled-release formulations, connecting to the broader sustained-release drug technology market projected to exceed $40 billion by 2026.

Emerging applications in biomedical imaging probes have sparked new interest in 6344-42-9, particularly for fluorescence labeling techniques. This intersects with the booming diagnostic reagents sector, where users commonly search for "multifunctional linker molecules". The compound's benzylic position offers strategic modification opportunities, making it relevant to click chemistry methodologies—a hot topic in nanomaterial functionalization research.

Quality benchmarks for Ethyl 2-(benzylamino)acetate Hydrochloride typically specify ≥98% purity, with chromatographic data becoming a key purchasing criterion. This responds to the pharmaceutical industry's emphasis on QC documentation transparency, a frequent subject in GMP compliance discussions. The compound's melting point range (typically 160-163°C) serves as an important physical characteristic for identity confirmation, addressing common verification questions in analytical chemistry communities.

Recent technological advancements have enabled more efficient large-scale synthesis of 6344-42-9, reducing production costs while maintaining batch-to-batch consistency—a major concern for contract manufacturing organizations. This development aligns with search trends focusing on "cost-effective chiral building blocks" and "scalable organic synthesis". The compound's zwitterionic potential at physiological pH also makes it interesting for ion-exchange chromatography studies, connecting to popular queries about protein purification techniques.

In academic settings, Ethyl 2-(benzylamino)acetate Hydrochloride serves as an excellent model compound for teaching protecting group strategies and carboxylate activation mechanisms. These educational applications respond to frequent searches from chemistry educators seeking "demonstration reagents for amide bond formation". The benzyl group's orthogonal deprotection characteristics further enhance its utility in multistep synthesis curricula.

The compound's molecular weight (229.72 g/mol) and stoichiometric properties facilitate precise calculations in reaction optimization studies, a practical aspect often explored in process chemistry blogs. Its hydrogen bonding capacity also makes it relevant to contemporary studies on supramolecular assembly, addressing growing interest in molecular recognition systems. These multifaceted applications ensure CAS 6344-42-9 remains a compound of enduring scientific and industrial significance.

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