• 1. A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A
  William Doherty,Eva-Maria Dürr,Hannah T. Baddock,Sook Y. Lee,Peter J. McHugh,Tom Brown,Mathias O. Senge,Eoin M. Scanlan,Joanna F. McGouran Org. Biomol. Chem. 2019 17 8094
• 2. Selective chemical modification of DNA with alkoxy- and benzyloxyamines
  Lorina Gjonaj,Gerard Roelfes Org. Biomol. Chem. 2015 13 6059
• 3. Synthesis of (Z?)-N-(2-amino-1,2-dicyanovinyl)formamide O-alkyloximes and a study of their cyclization in the presence of base
  Brian L. Booth,Flora A. T. Costa,Zahid Mahmood,Robin G. Pritchard,M. Fernanda Proen?a J. Chem. Soc. Perkin Trans. 1 1999 1853
• 4. A bodipy based hydroxylamine sensor
  Adam C. Sedgwick,Robert S. L. Chapman,Jordan E. Gardiner,Lucy R. Peacock,Gyoungmi Kim,Juyoung Yoon,Steven D. Bull,Tony D. James Chem. Commun. 2017 53 10441
• 5. Competition-driven selection in covalent dynamic networks and implementation in organic reactional selectivity
  P. Kova?í?ek,A. C. Meister,K. Flídrová,R. Cabot,K. Kova?í?ková,J.-M. Lehn Chem. Sci. 2016 7 3215

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives
• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides

Professional Introduction to O-Benzylhydroxylamine (CAS No. 622-33-3)

O-Benzylhydroxylamine, a compound with the chemical formula C?H?NO? and CAS number 622-33-3, is a significant intermediate in the field of organic synthesis and pharmaceutical research. This compound has garnered considerable attention due to its versatile applications in the development of various bioactive molecules. The benzyl group and hydroxylamine moiety present in its structure contribute to its reactivity, making it a valuable building block for synthesizing more complex molecules.

The utility of O-Benzylhydroxylamine extends across multiple domains, particularly in medicinal chemistry and biochemical research. Its role as a protecting group for primary amines is well-documented, where it prevents unwanted side reactions during synthetic processes. This property is particularly crucial in multi-step syntheses where selective functionalization is required.

In recent years, the demand for high-purity O-Benzylhydroxylamine has surged, driven by advancements in drug discovery and development. Researchers are increasingly leveraging this compound to design novel therapeutic agents targeting various diseases. The ability to introduce or remove the benzyl group selectively allows for greater control over the chemical properties of the final product, which is essential for optimizing pharmacokinetic profiles.

One of the most compelling applications of O-Benzylhydroxylamine is in the synthesis of protease inhibitors. Proteases are enzymes that play a pivotal role in numerous biological pathways, making them attractive targets for therapeutic intervention. By incorporating this compound into drug candidates, scientists can modulate protease activity, which has implications in treating conditions such as cancer, inflammation, and infectious diseases. Recent studies have highlighted its effectiveness in generating potent inhibitors with improved selectivity and reduced toxicity.

The chemical reactivity of O-Benzylhydroxylamine also makes it a valuable tool in the development of diagnostic agents. Its ability to participate in nucleophilic substitution reactions allows for the creation of labeled compounds used in imaging techniques and biomarker detection. These applications are particularly relevant in personalized medicine, where precise molecular probes are essential for accurate disease diagnosis and monitoring.

The synthesis of O-Benzylhydroxylamine typically involves the reaction of benzaldehyde with hydroxylamine hydrochloride under controlled conditions. This process requires careful optimization to ensure high yield and purity, which are critical for pharmaceutical applications. Advances in synthetic methodologies have enabled more efficient production techniques, reducing costs and environmental impact while maintaining stringent quality standards.

In conclusion, O-Benzylhydroxylamine (CAS No. 622-33-3) is a multifaceted compound with broad applications in pharmaceuticals and biochemical research. Its role as a protecting group and intermediate in drug synthesis underscores its importance in modern medicinal chemistry. As research continues to uncover new therapeutic targets and diagnostic methods, the demand for high-quality O-Benzylhydroxylamine is expected to grow, driving further innovation in its production and application.

• 54484-68-3(O-(naphthalen-1-yl)methylhydroxylamine)
• 75959-26-1(O-(2-methylphenyl)methylhydroxylamine)
• 30777-81-2(Hydroxylamine,O-[[4-[(aminooxy)methyl]phenyl]methyl]-, hydrochloride (1:2))
• 30777-79-8(Hydroxylamine,O-[[2-[(aminooxy)methyl]phenyl]methyl]-, hydrochloride (1:2))
• 83670-44-4(O-(4-methylphenyl)methylhydroxylamine)
• 2687-43-6(O-Benzylhydroxylamine hydrochloride)
• 935-05-7(Nitrous acid benzyl ester)
• 30777-80-1(Hydroxylamine,O-[[3-[(aminooxy)methyl]phenyl]methyl]-, hydrochloride (1:2))
• 792902-18-2(O-(3,5-dimethylphenyl)methylhydroxylamine)
• 38936-62-8(1-(aminooxy)methyl-4-methylbenzene hydrochloride)