A hydroxamic-acid-containing nucleoside inhibits DNA repair nuclease SNM1A?
Organic & Biomolecular Chemistry Pub Date: 2019-08-05 DOI: 10.1039/C9OB01133A
Abstract
Nine modified nucleosides, incorporating zinc-binding pharmacophores, have been synthesised and evaluated as inhibitors of the DNA repair nuclease SNM1A. The series included oxyamides, hydroxamic acids, hydroxamates, a hydrazide, a squarate ester and a squaramide. A hydroxamic acid-derived nucleoside inhibited the enzyme, offering a novel approach for potential therapeutic development through the use of rationally designed nucleoside derived inhibitors.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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