Production Method 1

615-10-1

874-66-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Potassium carbonate ,  Iron chloride (FeCl3) ,  Ferrous chloride ,  Chloroauric acid ;  0.3 MPa, rt; 4 h, 140 °C

Reference

A tunable process: catalytic transformation of renewable furfural with aliphatic alcohols in the presence of molecular oxygen

Tong, Xinli; et al, Chemical Communications (Cambridge, 2015, 51(17), 3674-3677

Production Method 2

615-10-1

874-66-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Cesium carbonate ,  Diaqua[5-(1H-1,2,3-triazol-1-yl)-1,3-benzenedicarboxylato(2-)-κO1,κO′1]cobalt Solvents: 1-Propanol ;  4 h, 0.3 MPa, 140 °C

Reference

Selective transformation of renewable furfural catalyzed by diverse active species derived from 2D Co-based metal-organic frameworks

Ning, Liangmin; et al, Journal of Catalysis, 2017, 352, 480-490

Production Method 3

615-10-1

874-66-8

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: 1,10-Phenanthroline ,  Cobalt diacetate ,  Cesium carbonate ,  Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) ;  4 h, 0.3 atm, 140 °C

Reference

Sustainable and Cost-Effective Protocol for Cascade Oxidative Condensation of Furfural with Aliphatic Alcohols

Yu, Linhao; et al, ACS Sustainable Chemistry & Engineering, 2016, 4(4), 1894-1898

Production Method 4

615-10-1

874-66-8

1204-93-9

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Palladium oxide (PdO) ,  Titania ;  0.3 MPa, rt → 140 °C; 4 h, 140 °C

Reference

Selective carbon-chain increasing of renewable furfural utilizing oxidative condensation reaction catalyzed by mono-dispersed palladium oxide

Tong, Xinli; et al, Molecular Catalysis, 2019, 477,

Production Method 5

615-10-1

874-66-8

1204-93-9

Reaction Conditions

1.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Ceria ,  Copper oxide (CuO) ;  4 h, 0.3 MPa, 140 °C

Reference

Efficient and selective transformation of biomass-derived furfural with aliphatic alcohols catalyzed by a binary Cu-Ce oxide

Tong, Xinli; et al, Catalysis Today, 2017, 298, 175-180

Production Method 6

615-10-1

874-66-8

1204-93-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Ceria ,  Copper oxide (CuO)
2.1 Reagents: Potassium carbonate ,  Oxygen Catalysts: Ceria ,  Copper oxide (CuO) ;  4 h, 0.3 MPa, 140 °C

Reference

Efficient and selective transformation of biomass-derived furfural with aliphatic alcohols catalyzed by a binary Cu-Ce oxide

Tong, Xinli; et al, Catalysis Today, 2017, 298, 175-180

2-Furancarboxylic Acid N-Propyl Ester Preparation Products

• 2-Methyl-3-(2-furyl)acrolein (874-66-8)
• 2-Furancarboxylic Acid N-Propyl Ester (615-10-1)
• 2-(Dipropoxymethyl)furan (1204-93-9)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Furans Furoic acid esters
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Furans Furoic acid and derivatives Furoic acid esters
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Study of 2-Furancarboxylic Acid N-Propyl Ester (CAS: 615-10-1)

2-Furancarboxylic Acid N-Propyl Ester (CAS: 615-10-1) is a furan derivative that has garnered significant attention in the chemical, biological, and pharmaceutical research communities due to its versatile applications. Recent studies have explored its potential as a bioactive compound, its role in synthetic chemistry, and its utility in drug development. This research brief synthesizes the latest findings related to this compound, providing insights into its properties, synthesis methods, and emerging applications.

One of the key areas of interest is the compound's role as a flavoring agent and fragrance enhancer. Recent research has demonstrated that 2-Furancarboxylic Acid N-Propyl Ester exhibits unique organoleptic properties, making it a valuable additive in the food and cosmetic industries. Studies have also highlighted its stability under various environmental conditions, which is critical for industrial applications. Additionally, its low toxicity profile has been confirmed through in vitro and in vivo assays, further supporting its safe use in consumer products.

In the realm of synthetic chemistry, advancements have been made in the efficient synthesis of 2-Furancarboxylic Acid N-Propyl Ester. A 2023 study published in the Journal of Organic Chemistry detailed a novel catalytic method that significantly improves yield and reduces reaction time. This method employs a palladium-based catalyst under mild conditions, offering a greener alternative to traditional synthesis routes. Such innovations are expected to lower production costs and enhance scalability, making the compound more accessible for research and commercial use.

Pharmaceutical research has also explored the bioactive potential of 2-Furancarboxylic Acid N-Propyl Ester. Preliminary studies suggest that it may exhibit antimicrobial and anti-inflammatory properties. A recent in vitro study demonstrated its efficacy against certain Gram-positive bacteria, with minimal inhibitory concentrations (MICs) comparable to established antibiotics. While these findings are promising, further in vivo studies are needed to validate its therapeutic potential and elucidate its mechanism of action.

Another emerging application of 2-Furancarboxylic Acid N-Propyl Ester is in the field of material science. Researchers have investigated its use as a precursor for biodegradable polymers. Its furan ring structure provides a unique platform for polymerization, resulting in materials with desirable mechanical and thermal properties. These biodegradable polymers could potentially replace conventional plastics in specific applications, contributing to sustainability efforts.

Despite these advancements, challenges remain in the widespread adoption of 2-Furancarboxylic Acid N-Propyl Ester. Regulatory hurdles, particularly in the pharmaceutical and food industries, require comprehensive safety assessments. Moreover, the scalability of novel synthesis methods needs to be demonstrated at an industrial scale. Addressing these challenges will be critical for unlocking the full potential of this compound.

In conclusion, 2-Furancarboxylic Acid N-Propyl Ester (CAS: 615-10-1) represents a multifaceted compound with applications spanning multiple industries. Recent research has shed light on its synthesis, bioactive properties, and material science applications, paving the way for future innovations. Continued interdisciplinary collaboration will be essential to overcome existing challenges and fully realize the benefits of this promising compound.

• 10551-58-3(5-Acetoxymethyl-2-furaldehyde)
• 2527-96-0(Methyl 5-Methyl-2-furoate)
• 611-13-2(Methyl 2-furoate)
• 614-99-3(Ethyl 2-furoate)
• 39251-88-2(N-Octyl 2-Furancarboxylate)
• 36802-01-4(Methyl 5-(hydroxymethyl)furan-2-carboxylate)
• 4208-49-5(Allyl Furoate)
• 4282-32-0(Dimethyl furan-2,5-dicarboxylate)
• 1334-82-3(Furancarboxylic acid,pentyl ester)
• 1335-40-6(Ethyl 2-furoate)