• 1. Copper-catalyzed borylamidation of vinyl arenes with isocyanates
  Zhenni Su,Yunqiu Feng,Rong Zou,Xianfan Qiu,Jian Wang,Chuanzhou Tao Chem. Commun. 2020 56 7483
• 2. Synthesis and structural characterisation of dithiocarbamate-stabilised dimeric molybdenum(V) imido complexes via oxo substitution reactions with organic isocyanates
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• 3. Notes
  Roy J. Gritter,Royce S. Woosley,Peter Walker,A. J. Birch,J. Winter,Karl O. Christe,Attila E. Pavlath,W. Carruthers,G. Harris,I. C. MacWilliam,G. Valkanas,N. K. Roberts,Henri Ulrich,A. A. R. Sayigh,Alwyn G. Evans,B. J. Tabner,Joseph V. Urenovitch,Rade Pejic,Alan G. MacDiarmid,B. R. Brown,A. H. Todd,J. G. Pritchard,R. L. Vollmer,Paul J. Scheuer,Frank Werny,R. K. Smalley,H. Suschitzky,C. D. Foxall,J. W. W. Morgan,D. F. Evans,G. O. P. Doherty,N. B. Haynes,W. B. Whalley,H. J. Rylance J. Chem. Soc. 1963 5544
• 4. Featuring Xantphos
  Piet W. N. M. van Leeuwen,Paul C. J. Kamer Catal. Sci. Technol. 2018 8 26
• 5. Synthesis of alkynamides through reaction of alkyl- or aryl-substituted alkynylaluminums with isocyanates
  Soohong Cho,Yeonjoo Lee,Kyeongmin Lee,Hwiwoong Lee,Yunmi Lee,Byunghyuck Jung Org. Biomol. Chem. 2022 20 139

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Toluenes
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

1-Isocyanato-2-Methylbenzene: A Comprehensive Overview

1-isocyanato-2-methylbenzene, also known as o-methylbenzene isocyanate, is a versatile organic compound with the CAS number 614-68-6. This compound is widely recognized in the chemical industry for its unique properties and applications. Its molecular formula, C8H7N, indicates a structure where an isocyanate group (-NCO) is attached to a methyl-substituted benzene ring. This substitution pattern at the ortho position (position 2) of the benzene ring gives it distinct chemical reactivity and physical properties.

The synthesis of 1-isocyanato-2-methylbenzene typically involves the reaction of an amine with phosgene or other carbonylating agents. Recent advancements in catalytic systems have enabled more efficient and environmentally friendly production methods. For instance, researchers have explored the use of heterogeneous catalysts to enhance reaction yields and reduce byproduct formation. These developments underscore the compound's importance in modern chemical manufacturing.

1-isocyanato-2-methylbenzene exhibits a high degree of reactivity due to the electrophilic nature of the isocyanate group. This makes it a valuable intermediate in the synthesis of various polymers, including polyurethanes and isocyanurate-based materials. In recent studies, its application in the development of thermally stable polymers has gained significant attention. For example, scientists have demonstrated its potential in creating high-performance adhesives and coatings that exhibit excellent resistance to thermal degradation.

In terms of physical properties, 1-isocyanato-2-methylbenzene has a melting point of approximately -5°C and a boiling point around 95°C at standard atmospheric pressure. Its density is about 1.05 g/cm3, making it slightly denser than water. These properties make it suitable for use in various industrial processes where controlled reactivity and handling are essential.

The compound's applications extend beyond polymer synthesis. It is also employed as an intermediate in the production of pharmaceuticals, agrochemicals, and specialty chemicals. Recent research has highlighted its role in the development of novel drug delivery systems, where its reactivity allows for the creation of biocompatible materials with tailored properties.

Safety considerations are paramount when handling 1-isocyanato-2-methylbenzene. The compound is highly reactive and can release toxic fumes when exposed to heat or open flames. Proper ventilation and personal protective equipment are essential during its use and storage. Regulatory bodies have established strict guidelines to ensure safe handling practices, reflecting its importance as a key industrial chemical.

In conclusion, 1-isocyanato-2-methylbenzene, with its CAS number 614-68-6, remains a critical component in numerous industrial applications. Its unique chemical properties, coupled with ongoing advancements in synthesis and application techniques, ensure its continued relevance in both academic research and commercial production.

• 9017-01-0(Benzene,1,3-diisocyanatomethyl-, homopolymer)
• 109909-28-6(2-Hydroxypropyl 2-methyl-2-propenoate polymer with hydroxy-terminated hydrogenated polybutadiene and TDI)
• 137060-28-7(Furan,tetrahydro-3-methyl-, polymer with 2,4-diisocyanato-1-methylbenzene andtetrahydrofuran, 2-hydroxyethyl acrylate-blocked)
• 16959-10-7(Benzene,2,4-diisocyanato-1,3,5-trimethyl-)
• 2958-62-5(2,4,6-Trimethylphenyl isocyanate)
• 28556-81-2(2,6-Dimethylphenyl isocyanate)
• 22683-71-2(Benzenamine,3-isocyanato-2-methyl-)
• 26006-20-2(Benzene, 2,4-diisocyanato-1-methyl-, homopolymer)
• 40397-98-6(2-isocyanato-1,4-dimethylbenzene)
• 51163-29-2(1-isocyanato-2,4-dimethylbenzene)