• 1. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 2. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
• 5. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Hydroxy bile acids, alcohols and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Bile acids, alcohols and derivatives Hydroxy bile acids, alcohols and derivatives

Comprehensive Overview of Norcholic Acid (CAS No. 60696-62-0): Properties, Applications, and Research Insights

Norcholic acid (CAS No. 60696-62-0) is a bile acid derivative that has garnered significant attention in pharmaceutical and biochemical research due to its unique structural properties and potential therapeutic applications. As a norsteroid, it differs from typical bile acids by the absence of a methyl group at the C-24 position, which influences its metabolic pathways and biological activity. This compound is often studied alongside other bile acid analogs for its role in lipid metabolism, liver function, and as a precursor for synthetic drug development.

In recent years, the demand for norcholic acid research has surged, driven by growing interest in metabolic disorders such as non-alcoholic fatty liver disease (NAFLD) and cholesterol homeostasis. Researchers are particularly intrigued by its potential to modulate FXR (farnesoid X receptor) and TGR5 (Takeda G protein-coupled receptor 5), key targets in treating metabolic syndromes. Online searches for "norcholic acid benefits" and "60696-62-0 solubility" reflect the compound's relevance in both academic and industrial settings.

The synthesis of norcholic acid typically involves the oxidation of chenodeoxycholic acid or microbial transformation, with optimization strategies frequently discussed in journals focusing on steroid chemistry. Its physicochemical properties—including a molecular weight of 376.53 g/mol and a melting point of 180–182°C—make it suitable for formulation studies. Notably, its water solubility and lipophilicity are critical parameters for drug delivery system design, a topic trending in pharmaceutical nanotechnology forums.

Emerging applications of CAS 60696-62-0 extend to gut microbiome modulation, a hot topic in 2024 due to increasing awareness of the gut-liver axis. Studies suggest that norcholic acid derivatives may influence microbial populations that produce secondary bile acids, linking it to broader discussions on personalized nutrition and probiotic therapies. This aligns with frequent search queries like "bile acids and gut health" and "norsteroids in medicine."

From a regulatory perspective, norcholic acid is classified as a non-hazardous research chemical, but its handling requires standard laboratory precautions. Analytical methods such as HPLC purity testing and mass spectrometry characterization are routinely employed, as evidenced by patents focusing on high-purity norcholic acid preparation. The compound's stability under various pH conditions also makes it a candidate for biomarker research in chronic liver diseases.

In conclusion, 60696-62-0 represents a versatile scaffold in medicinal chemistry, with ongoing investigations into its structure-activity relationships and therapeutic potential. As interest in metabolic engineering and bile acid therapeutics continues to rise, norcholic acid remains a focal point for innovation in drug discovery and nutraceutical development.

• 474-25-9(Chenodeoxycholic acid)
• 128-13-2(Ursodeoxycholic acid)
• 434-13-9(Lithocholic acid)
• 459789-99-2(Obeticholic acid)
• 112076-61-6(Deoxycholic acid-d)
• 81-25-4(Cholic acid)
• 83-44-3(Deoxycholic acid)
• 83-49-8(Hyodeoxycholic acid)
• 132465-11-3(CDC)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)