Cas no 599-79-1 (Sulfasalazine)

Sulfasalazine is a sulfonamide-derived compound combining 5-aminosalicylic acid (5-ASA) and sulfapyridine, linked via an azo bond. It is primarily used as an anti-inflammatory and immunosuppressive agent, particularly in the management of inflammatory bowel diseases (e.g., ulcerative colitis, Crohn's disease) and rheumatoid arthritis. Its mechanism involves bacterial cleavage of the azo bond in the colon, releasing active 5-ASA locally to reduce inflammation, while sulfapyridine contributes systemic effects. Key advantages include targeted colonic delivery, proven efficacy in chronic inflammatory conditions, and a well-established safety profile with decades of clinical use. Sulfasalazine also exhibits cost-effectiveness compared to newer biologics, making it a first-line option in certain therapeutic regimens.
Sulfasalazine structure
Sulfasalazine structure
Product Name:Sulfasalazine
CAS No:599-79-1
MF:C18H14N4O5S
MW:398.392562389374
MDL:MFCD00057363
CID:38690
PubChem ID:87560165
Update Time:2026-05-14

Sulfasalazine Chemical and Physical Properties

Names and Identifiers

    • Salazosulfapyridine
    • SULFASALAZINE
    • SSZ
    • 5-(p-(2-pyridylsulfamoyl)phenylazo)salicylic acid
    • 5-[4-(2-PYRIDYLSULFAMOYL)PHENYLAZO]SALICYLIC ACID
    • 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic acid
    • NSC 667219
    • Salicylazosulfapyridine
    • Sulfidefluor 7 AM
    • 5-((p-(2-pyridylsulfamoyl)phenyl)azo)-salicylic aci
    • accucol
    • azopyrin
    • reupirin
    • rorasul
    • salisulf
    • sas-500
    • sasp
    • si-88
    • sulcolon
    • 2-Hydroxy-5-{{4-[(2-pyridinylamino)sulfonyl]phenyl}azo}benzoic acid
    • Azulfidine
    • Sulphasalazine
    • Salazopyrin
    • Asulfidine
    • Salazopyridin
    • Colo-Pleon
    • Salazopiridazin
    • Benzosulfa
    • Azopyrine
    • Salazosulfapyridin
    • w-t Sasp oral
    • Sulfasalazinum
    • Sulfasalazina
    • Sulfasalazin
    • Azulfidine EN
    • Sulfazalazine
    • Azulfidine EN-tabs
    • Salazosulfapiridina
    • Salazosulfapyridinum
    • Azosulfidin
    • Salazo-sulfapyridinum
    • 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid
    • 5-(4-(2-
    • Sulfasalazine
    • MDL： MFCD00057363
    • Inchi： 1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
    • InChI Key： NCEXYHBECQHGNR-QZQOTICOSA-N
    • SMILES： S(C1C([H])=C([H])C(=C([H])C=1[H])/N=N/C1C([H])=C([H])C(=C(C(=O)O[H])C=1[H])O[H])(N([H])C1=C([H])C([H])=C([H])C([H])=N1)(=O)=O

Computed Properties

  • Exact Mass: 398.06800
  • Monoisotopic Mass: 398.068
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 9
  • Heavy Atom Count: 28
  • Rotatable Bond Count: 6
  • Complexity: 657
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • Functional 3D Acceptor Count: 7
  • Functional 3D Anion Count: 2
  • isomeric RMSD: 0.8
  • CID conformational isomer Count: 106
  • Topological Polar Surface Area: 146
  • Surface Charge: 0
  • Functional 3D Donor Count: 2
  • Functional 3D ring Count: 3
  • Rotatable Bond Count: 6
  • XLogP3: -0.7
  • Topological Polar Surface Area: 150

Experimental Properties

  • Color/Form: Brownish yellow fine crystals
  • Density: 1.3742 (rough estimate)
  • Melting Point: 260-265?°C (dec.) (lit.)
  • Boiling Point: 689.3°C at 760 mmHg
  • Flash Point: 335.4oC
  • Refractive Index: 1.6000 (estimate)
  • Solubility: NH4OH 1 M: 50?mg/mL, clear, red
  • Water Partition Coefficient: <0.1 g/100 mL at 25 oC
  • PSA: 149.69000
  • LogP: 4.85540
  • Merck: 8942
  • Solubility: Slightly soluble in ethanol, insoluble in water, chloroform, ether, benzene
  • Vapor Pressure: 0.0±2.3 mmHg at 25°C

Sulfasalazine Security Information

  • Symbol: GHS08
  • Prompt：warning
  • Signal Word：Danger
  • Hazard Statement： H351
  • Warning Statement： P201-P202-P280-P308+P313-P405-P501
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：2
  • Hazard Category Code： 42/43
  • Safety Instruction： S22-S29/56-S45
  • FLUKA BRAND F CODES：8
  • RTECS：VO6250000
  • Hazardous Material Identification： Xn
  • Risk Phrases：R42/43
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Sulfasalazine Customs Data

  • HS CODE：29350090
  • Customs Data：

    China Customs Code:

    2935009090

    Overview:

    2935009090 Other sulphonates(Acyl)amine. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:35.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Sulfasalazine Pricemore >>

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Sulfasalazine Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:599-79-1)柳氮磺胺吡啶
Order Number:LE1682461;LE15202
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:32
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Suzhou Senfeida Chemical Co., Ltd
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(CAS:599-79-1)Sulfasalazine
Order Number:sfd454;1682461
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Quantity:200KG/Company Customization
Purity:99%/98%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally
Amadis Chemical Company Limited
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(CAS:599-79-1)Sulfasalazine
Order Number:A832559
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 15:28
Price ($):218.0

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Recommended suppliers
Tiancheng Chemical (Jiangsu) Co., Ltd
(CAS:599-79-1)柳氮磺胺吡啶
LE1682461;LE15202
Purity:99%/99%
Quantity:25KG,200KG,1000KG/25KG,200KG,1000KG
Price ($):Inquiry/Inquiry
Email
Suzhou Senfeida Chemical Co., Ltd
(CAS:599-79-1)Sulfasalazine
sfd454;1682461
Purity:99%/98%
Quantity:200KG/Company Customization
Price ($):Inquiry/Inquiry
Email