Cas no 119-36-8 (Methyl salicylate)

Methyl salicylate is an organic ester derived from salicylic acid and methanol, commonly recognized for its characteristic wintergreen aroma. It serves as a versatile intermediate in pharmaceuticals, fragrances, and flavorings due to its anti-inflammatory and analgesic properties. The compound exhibits excellent solubility in organic solvents, facilitating its use in topical formulations such as liniments and ointments for pain relief. Its stability under standard conditions and high purity make it suitable for industrial and laboratory applications. Methyl salicylate is also employed as a flavoring agent in food products and as a scent enhancer in cosmetics. Its dual functionality as both an active ingredient and a fragrance component underscores its broad utility.

Methyl salicylate structure

Product Name:Methyl salicylate

CAS No:119-36-8

MF:C₈H₈O₃

MW:152.147322654724

MDL:MFCD00002214

CID:35909

PubChem ID:24897111

Update Time:2025-10-28

Methyl salicylate Chemical and Physical Properties

Names and Identifiers

- Methyl Salicylate
- 2-Carbomethoxyphenol
- 2-HYDROXYBENZOIC ACID METHYL ESTER
- 2-(methoxycarbonyl)phenol
- analgit
- BETULA OIL
- BIRCH OIL
- BIRCH OIL, SWEET
- exagien
- FEMA 2154
- FEMA 2745
- Flucarmit
- Gaultheria oil
- Linsal
- METHYL 2-HYDROXYBENZOATE
- METHYL HYDROXYBENZOATE
- METHYLIS SALICYLAS
- METHYL-O-HYDROXYBENZOATE
- o-Hydroxybenzoic acid methyl ester
- OIL OF WINTERGREEN
- Birch-Me
- Salicylic acid methylester
- SALICYLIC ACID METHYLESTER(AS)
- 2-HYDROXY-BENZOIC ACID METHYL ESTER
- 2-METHYL-5-(PROPAN-2-YL)PHENOL
- Methyl Salicylate (AS)
- METHYL SALICYLATE NF
- METHYL SALICYLATE NF FCC
- METHYL SALICYLATE: NF
- methyl-2-hydroxybenzoate
- Salicylic acidMethyl ester
- salicylic-acid methyl ester
- Sweet birch oil
- Teaberry oil
- Wintergreen oil
- Methyl o-hydroxybenzoate
- Betula
- NSC 8204
- PredaLure
- Salicylic Acid Methyl Ester
- Methyl salicylate
- Spicewood Oil
- Wintergruenoel
- Gaultheriaoel
- Natural Wintergreen Oil
- Betula Lenta
- Salicylic acid, methyl ester
- Synthetic Wintergreen Oil
- Benzoic acid, 2-hydroxy-, methyl ester
- Gaultheria oil, artificial
- Wintergr
- La Flecha Japonesa
- AI3-00090
- Balsamo de Vaca Mascura
- Z19703590
- METHYL SALICYLATE (II)
- Methyl salicylate, Vetec(TM) reagent grade, 99%
- D01087
- METHYL SALICYLATE [WHO-DD]
- DB09543
- Methyl salicylate 100 microg/mL in Acetonitrile
- Germa Ubre Mastitis
- 90045-28-6
- Theragesic (Salt/Mix)
- ReLeaf Arthritis Balm
- Natralia Cramp Relief
- F0001-0306
- Methyl ester 2-hydroxy-benzoic acid
- Salonpas (Salt/Mix)
- Dermaline 3 in 1 Roll On
- Zenol Cool
- CS-B1799
- InChI=1/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H
- CCRIS 6259
- Germa Linimento Ubre Plus
- SUNSET PAIN RELIEF-HEATING RELIEF
- Methyl Salicylate,(S)
- FEMA No. 2154
- CHEBI:31832
- EPA Pesticide Chemical Code 076601
- 1-O-methylsalicylate
- NCGC00254104-01
- Neuro Max Pain and Muscle Relief Gel
- EINECS 204-317-7
- SCHEMBL5312
- Wintergreen
- KRONA WART REMOVER
- HYSAN HUA TUO MEDICATED
- NCGC00091106-01
- NCGC00091106-03
- Methyl salicylate, >=98%, FCC, FG
- Methyl salicylate (TN)
- Caswell No. 577
- methylsalicylate
- METHYL SALICYLATE [USP-RS]
- BBL010504
- NSC8204
- Methyl salicylate, natural, 98%, FCC, FG
- AB01275470-01
- WLN: QR BVO1
- METHYL SALICYLATE, ALOE
- 135952-76-0
- 68917-75-9
- METHYL SALICYLATE [MART.]
- SY008800
- Milagroso
- METHYL SALICYLATE (MART.)
- BCP29151
- HMS1398J05
- DTXSID5025659
- METHYL SALICYLATE [HSDB]
- METHYL SALICYLATE [II]
- Methyl salicylate, Pharmaceutical Secondary Standard; Certified Reference Material
- Metylester kyseliny salicylove
- FlexSport Roll On
- FEMA No. 2745
- XCEPTOR CBD PAINMENTHOL
- FEMA Number 2745
- UNII-LAV5U5022Y
- teds topical pain cream
- HY-Y0189
- METHYL SALICYLATE [VANDF]
- Mascura la Vaca Plus
- MFCD00002214
- Veneno de AbejaAceite De Vibora Brand
- wintergreen leaf extract
- NS00008765
- Koong Yick Hung Fa
- 8024-54-2
- HMS3885C04
- METHYL SALICYLATE (EP MONOGRAPH)
- SR-05000001473-1
- COATS ALOE ANALGESIC
- 9041-28-5
- Methyl salicylate, SAJ first grade, >=98.0%
- STK397388
- 1335435-40-9
- 68917-50-0
- METHYL SALICYLATE (USP-RS)
- 2-Hydroxybenzoic acid, methyl ester
- Hyundai Moolpas F
- Methyl salicylate, BioXtra
- Tox21_201543
- Germa Manteca Ubre Plus (RED)
- Methyl salicylate, puriss., 99.0-100.5%
- Q407669
- Methylester kyseliny salicylove [Czech]
- Methyl ester of 2-hydroxy-benzoic acid
- Bumooly-S
- Methyl salicylate, analytical standard
- METHYL SALICYLATE COMPONENT OF SALONPAS
- Germa Manteca Ubre Plus (YELLOW)
- Methyl salicylate, ReagentPlus(R), >=99% (GC)
- EN300-15491
- Balsamo de UbreMascura
- AC-11584
- Flavor,wintergreen
- BRN 0971516
- Panalgesic
- TS-02010
- CCG-266225
- Flexitol Foot and Knee Pain Relief
- CHEMBL108545
- HMS2089H12
- Methyl Salicylate 2%
- methyl-salicylate
- SR-05000001473
- D70335
- Methyl salicylate (natural)
- Methyl salicylate [JAN]
- BIDD:ER0323
- METHYL SALICYLATE [FCC]
- METHYL SALICYLATE,SYNTHETIC [VANDF]
- Kofal Original
- CAS-119-36-8
- Methyl2-Hydroxybenzoate
- Metylester kyseliny salicylove [Czech]
- Abejas y Viboras Roll On
- DTXCID805659
- EC 204-317-7
- Oils,wintergreen
- foot worksarthritis achy foot and muscle
- METHYL SALICYLATE [FHFI]
- HSDB 1935
- NSC-8204
- SALONPAS COMPONENT METHYL SALICYLATE
- Ling Nam Hung Far
- Ben Gay
- 302912-49-8
- Methyl salicylate, 98%
- METHYL SALICYLATE [ORANGE BOOK]
- Methyl salicylate (JP17/NF)
- NCGC00091106-05
- Methyl-d3 salicylate-OD
- Benzoic acid, hydroxy-, methyl ester
- Germa Linimento Ubre Plus (Roll-On)
- FEMA No. 3113
- Methyl salicylate, United States Pharmacopeia (USP) Reference Standard
- East Coast Joint Relief
- Ubredol
- Enamine_001611
- BRD-K10103010-001-01-1
- Methyl salicylate [JAN:NF]
- Herb Street Sore Muscle Relief
- WINTERGREEN [VANDF]
- s3756
- Tox21_300137
- METHYL SALICYLATE [MI]
- Methylester kyseliny salicylove
- Q-100939
- Ted s Pain
- Germa Manteca Ubre Plus (TIN)
- METHYL SALICYLATE [EP MONOGRAPH]
- LAV5U5022Y
- Anthrapole ND
- DB-012808
- 2,4-Cyclohexadien-1-one,6-(hydroxymethoxymethylene)-(9CI)
- METHYL SALICYLATE (EP IMPURITY)
- 4-10-00-00143 (Beilstein Handbook Reference)
- GTPL2431
- Methyl salicylate, tested according to Ph.Eur.
- salicylate methyl ester
- NCGC00091106-04
- o-Hydroxybenzoic acid, methyl ester
- Methyl salicylate,synthetic
- Methyl Salicylate 10%
- Kofal
- Theragesic
- Methyl salicylate, 8CI
- Aspi-RubPain Reliever
- NCGC00259093-01
- DB-209477
- NCGC00091106-02
- 119-36-8
- XCEPTOR PAIN
- AKOS000118977
- Kofal Fuerte
- Tox21_111081
- METHYL SALICYLATE [EP IMPURITY]
- FM02407
- HY-Y0189R
- Methyl Salicylate (Standard)
- Methyl salicylate EP / USP / NF
- 204-317-7
- MDL： MFCD00002214
- Inchi： 1S/C8H8O3/c1-11-8(10)6-4-2-3-5-7(6)9/h2-5,9H,1H3
- InChI Key： OSWPMRLSEDHDFF-UHFFFAOYSA-N
- SMILES： COC(C1C(O)=CC=CC=1)=O
- BRN： 971516

Computed Properties

Exact Mass: 152.04700
Monoisotopic Mass: 152.047344113 g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 11
Rotatable Bond Count: 2
Complexity: 144
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: 4
XLogP3: 2.3
Topological Polar Surface Area: 46.5
Molecular Weight: 152.15

Experimental Properties

Color/Form: Oil
Density: 1.174?g/mL?at 25?°C(lit.)
Melting Point: ?8-?7?°C (lit.)
Boiling Point: 222?°C(lit.)
Flash Point: Degrees Fahrenheit:204.8°F
Degrees Celsius:96°C
Refractive Index: n20/D 1.536(lit.)
Solubility: less than 1 mg/mL at 66° F (NTP, 1992)
Water Partition Coefficient: 0.07 g/100 mL (20 oC)
Stability/Shelf Life: Stable. Incompatible with strong oxidizing agents, strong bases.
PSA: 46.53000
LogP: 1.17880
Odor: LIQUID HAVING THE CHARACTERISTIC ODOR OF WINTERGREEN
Refractive Index: INDEX OF REFRACTION: 1.5369 AT 20 °C/D; MAX ABSORPTION: 306 NM (LOG E= 3.64); SADTLER REFERENCE NUMBER: 2238 (IR, PRISM); MAX ABSORPTION (ALC): 238 NM (LOG E= 3.97)
Sensitiveness: Sensitive to humidity
Merck: 6120
Vapor Pressure: 1 mmHg ( 54 °C)
FEMA: 2745
Solubility: Slightly soluble in water, soluble in ethanol, diethyl ether, chloroform and acetic acid.

Methyl salicylate Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H302,H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：3082
WGK Germany：1
Hazard Category Code： 22
Safety Instruction： S26-S36-S24/25
FLUKA BRAND F CODES：8
RTECS：VO4725000
Hazardous Material Identification：
HazardClass：6.1(b)
PackingGroup：III
TSCA：Yes
Toxicity：LD50 orally in rats: 887 mg/kg (Jenner)
Storage Condition：Pure form -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
Safety Term：6.1(b)
Packing Group：III
Risk Phrases：R22; R36/38
Packing Group：III
Hazard Level：6.1(b)

Methyl salicylate Customs Data

HS CODE：2918219000
Customs Data：

China Customs Code:
2918230000

Overview:

2918230000 Other salicylic acid esters. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

Declaration elements:

Product Name, component content, use to

Summary:

2918230000 other esters of salicylic acid and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Methyl salicylate Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd.	M813577-2.5L	Birch-Me	119-36-8	AR,99%	2.5L	￥351.00	2022-10-10
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274518-SAMPLE-K	Methyl salicylate	119-36-8	≥98%, FCC, FG		587.6	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274518-1KG-K	Methyl salicylate	119-36-8	≥98%, FCC, FG	1KG	1029.64	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274518-5KG-K	Methyl salicylate	119-36-8	≥98%, FCC, FG	5KG	1897.79	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274518-10KG-K	Methyl salicylate	119-36-8	≥98%, FCC, FG	10KG	2206.66	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274502-SAMPLE-K	Methyl salicylate	119-36-8	natural, 98%, FG		587.6	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274502-500G-K	Methyl salicylate	119-36-8	natural, 98%, FG	500G	3073.57	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274502-1KG-K	Methyl salicylate	119-36-8	natural, 98%, FG	1KG	4897.62	2021-05-17
XI GE MA AO DE LI QI （ SHANG HAI ） MAO YI Co., Ltd.	W274502-5KG-K	Methyl salicylate	119-36-8	natural, 98%, FG	5KG	21854.46	2021-05-17
NAN JING HUA XUE SHI JI GU FEN Co., Ltd.	C0833620223- 500ml（玻瓶）	Methyl salicylate	119-36-8	99.5%	500ml	￥ 44.7	2021-05-18

Methyl salicylate Production Method

Methyl salicylate Suppliers

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:119-36-8)水楊酸甲酯

Order Number:LE25473457;LE1338;LE10197

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:48

Price ($):discuss personally

Email:[email protected]

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:119-36-8)Methyl salicylate

Order Number:sfd19258

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:38

Price ($):discuss personally

Email:[email protected]

Product Official Link

Methyl salicylate Spectrogram

GC-MS

EI-B

1H NMR

JEOL

CDCl3

13C NMR

NEVA

CDCl3

Methyl salicylate Related Literature

1. Biological and chemical insight into Gaultheria procumbens fruits: a rich source of anti-inflammatory and antioxidant salicylate glycosides and procyanidins for food and functional application

Piotr Michel,Sebastian Granica,Karolina Rosińska,Jaros?aw Rojek,?ukasz Poraj,Monika Anna Olszewska Food Funct. 2020 11 7532
2. Efficient scavenging of β-carotene radical cations by antiinflammatory salicylates

Hong Cheng,Ran Liang,Rui-Min Han,Jian-Ping Zhang,Leif H. Skibsted Food Funct. 2014 5 291
3. A supramolecular topical gel derived from a non-steroidal anti-inflammatory drug, fenoprofen, is capable of treating skin inflammation in mice

Joydeb Majumder,Pavani Yedoti,Parthasarathi Dastidar Org. Biomol. Chem. 2015 13 2300
4. Tandem buildup of complexity of aromatic molecules through multiple successive electrophile generation in one pot, controlled by varying the reaction temperature

Akinari Sumita,Yuko Otani,Tomohiko Ohwada Org. Biomol. Chem. 2016 14 1680
5. Highly sensitive electrochemical detection of methyl salicylate using electroactive gold nanoparticles

Yogeswaran Umasankar,Ramaraja P. Ramasamy Analyst 2013 138 6623

Related Categories

Additional information on Methyl salicylate

Methyl Salicylate: A Comprehensive Overview

Methyl salicylate, also known as CAS No. 119-36-8, is a versatile compound with a wide range of applications in various industries. Derived from the esterification of salicylic acid and methanol, this compound is widely recognized for its aromatic scent and diverse functional properties. In recent years, advancements in chemical synthesis and analytical techniques have further enhanced our understanding of methyl salicylate's potential applications and mechanisms of action.

Methyl salicylate has long been valued for its role in the fragrance industry, where it contributes to the characteristic scent of wintergreen and other natural aromas. Its ability to dissolve in both water and organic solvents makes it an ideal ingredient in perfumes, cosmetics, and personal care products. Moreover, methyl salicylate has been explored for its pharmacological properties, particularly in the context of anti-inflammatory and analgesic effects. Recent studies have highlighted its potential as a natural alternative to synthetic pain relievers, offering a safer profile for topical applications.

The chemical structure of methyl salicylate plays a pivotal role in its functionality. The molecule consists of a benzene ring substituted with a hydroxyl group at the ortho position and an ester group at the para position. This arrangement not only imparts its distinctive aroma but also influences its reactivity in various chemical reactions. Researchers have leveraged this structure to develop innovative derivatives with enhanced bioavailability and stability, opening new avenues for pharmaceutical applications.

In the field of biotechnology, methyl salicylate has gained attention as a signaling molecule in plant defense mechanisms. Studies have demonstrated that certain plants release methyl salicylate as part of their immune response to pathogens, suggesting potential applications in agricultural pest control and disease resistance enhancement. This discovery underscores the compound's role beyond traditional industrial uses, positioning it as a key player in sustainable agriculture practices.

Recent advancements in analytical chemistry have enabled more precise characterization of methyl salicylate's properties. Techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry have provided deeper insights into its stability under different environmental conditions and its interactions with biological systems. These findings are critical for optimizing its use in pharmaceutical formulations and ensuring safety standards across various applications.

The growing demand for natural and sustainable ingredients has further propelled the utilization of methyl salicylate in eco-friendly products. Its derivation from renewable resources aligns with global trends toward greener chemistry practices, making it an attractive option for environmentally conscious consumers. As industries continue to prioritize sustainability, the demand for methyl salicylate is expected to rise, driven by its dual appeal as both a functional ingredient and a sustainable choice.

In conclusion, methyl salicylate stands out as a multifaceted compound with significant contributions across fragrance, pharmaceuticals, biotechnology, and sustainability sectors. Ongoing research continues to unlock new potentials for this compound, ensuring its relevance in an ever-evolving market landscape.

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