Cas no 59887-17-1 (b-Endorphin (sheep))

Technical Introduction: β-Endorphin (sheep) β-Endorphin (sheep) is a synthetic opioid peptide that replicates the endogenous β-endorphin sequence found in sheep. This 31-amino-acid peptide is known for its high binding affinity to μ-opioid receptors, making it a valuable tool in neurobiological and pharmacological research. Its primary applications include studies on pain modulation, stress response, and reward mechanisms. The sheep-derived variant offers species-specific relevance for comparative endocrinology and veterinary research. With high purity (>95%) and verified bioactivity, this product ensures reliable performance in immunoassays, receptor binding studies, and functional assays. It is supplied lyophilized for stability and reconstituted under controlled conditions to maintain integrity.
b-Endorphin (sheep) structure
b-Endorphin (sheep) structure
Product Name:b-Endorphin (sheep)
CAS No:59887-17-1
MF:C155H250N42O44S
MW:3437.963534832
CID:374888
PubChem ID:16132311
Update Time:2025-11-01

b-Endorphin (sheep) Chemical and Physical Properties

Names and Identifiers

    • beta-ENDORPHIN (RAT)
    • DTXSID20208602
    • 59887-17-1
    • beta-Endorphin, triethoxy(3-isothiocyanatopropyl)-, (6R-(6alpha,7alpha,7(R*)))-
    • Beta Endorphin
    • beta-Endorphin (1-31)
    • CHEMBL3250455
    • beta-Endorphin bovine, camel, ovine, >=97% (HPLC)
    • b-Endorphin (sheep)
    • Inchi： 1S/C155H250N42O44S/c1-17-82(9)123(150(235)182-99(44-29-34-61-160)134(219)186-109(70-116(164)206)139(224)171-84(11)128(213)183-108(69-92-72-166-78-170-92)144(229)178-96(41-26-31-58-157)132(217)175-95(40-25-30-57-156)131(216)169-75-120(210)173-103(155(240)241)51-54-115(163)205)193-151(236)124(83(10)18-2)192-129(214)85(12)172-140(225)110(71-117(165)207)185-133(218)97(42-27-32-59-158)177-143(228)107(68-90-38-23-20-24-39-90)184-141(226)104(64-79(3)4)188-152(237)126(87(14)201)195-149(234)122(81(7)8)191-145(230)105(65-80(5)6)187-148(233)113-45-35-62-197(113)154(239)127(88(15)202)196-137(222)100(50-53-114(162)204)179-146(231)111(76-198)189-135(220)98(43-28-33-60-159)176-136(221)101(52-55-121(211)212)180-147(232)112(77-199)190-153(238)125(86(13)200)194-138(223)102(56-63-242-16)181-142(227)106(67-89-36-21-19-22-37-89)174-119(209)74-167-118(208)73-168-130(215)94(161)66-91-46-48-93(203)49-47-91/h19-24,36-39,46-49,72,78-88,94-113,122-127,198-203H,17-18,25-35,40-45,50-71,73-77,156-161H2,1-16H3,(H2,162,204)(H2,163,205)(H2,164,206)(H2,165,207)(H,166,170)(H,167,208)(H,168,215)(H,169,216)(H,171,224)(H,172,225)(H,173,210)(H,174,209)(H,175,217)(H,176,221)(H,177,228)(H,178,229)(H,179,231)(H,180,232)(H,181,227)(H,182,235)(H,183,213)(H,184,226)(H,185,218)(H,186,219)(H,187,233)(H,188,237)(H,189,220)(H,190,238)(H,191,230)(H,192,214)(H,193,236)(H,194,223)(H,195,234)(H,196,222)(H,211,212)(H,240,241)/t82-,83-,84-,85-,86+,87+,88+,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,122-,123-,124-,125-,126-,127-/m0/s1
    • InChI Key： HQALISCIMNBRAE-XJTHNYJFSA-N
    • SMILES： S(C)CC[C@@H](C(N[C@@H]([C@@H](C)O)C(N[C@@H](CO)C(N[C@@H](CCC(=O)O)C(N[C@@H](CCCCN)C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@@H]([C@@H](C)O)C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(=O)O)CCC(N)=O)=O)=O)CCCCN)=O)CCCCN)=O)CC1=CN=CN1)=O)=O)CC(N)=O)=O)CCCCN)=O)[C@@H](C)CC)=O)[C@@H](C)CC)=O)=O)=O)CCCCN)=O)CC1C=CC=CC=1)=O)CC(C)C)=O)[C@@H](C)O)=O)C(C)C)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)=O)NC([C@H](CC1C=CC=CC=1)NC(CNC(CNC([C@H](CC1C=CC(=CC=1)O)N)=O)=O)=O)=O

Computed Properties

  • Exact Mass: 3435.83000
  • Monoisotopic Mass: 3435.8336806g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 48
  • Hydrogen Bond Acceptor Count: 52
  • Heavy Atom Count: 242
  • Rotatable Bond Count: 118
  • Complexity: 7800
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 33
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 1001
  • XLogP3: -13.7
  • Topological Polar Surface Area: 1440?2

Experimental Properties

  • Color/Form: Not determined
  • PSA: 1442.65000
  • LogP: 3.57110

b-Endorphin (sheep) Security Information

  • WGK Germany：3
  • FLUKA BRAND F CODES：10

b-Endorphin (sheep) Pricemore >>

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b-Endorphin (sheep) Related Literature

Related Categories

Additional information on b-Endorphin (sheep)

Research Update on b-Endorphin (sheep) and Its Association with CAS 59887-17-1

Recent advancements in the field of chemical biology and pharmaceutical research have shed light on the role of b-Endorphin (sheep) and its potential interactions with compounds such as CAS 59887-17-1. This research brief aims to consolidate the latest findings, methodologies, and implications of these studies to provide a comprehensive overview for professionals in the field.

b-Endorphin, a peptide hormone derived from pro-opiomelanocortin (POMC), has been extensively studied for its analgesic and stress-relieving properties. The sheep-derived variant, b-Endorphin (sheep), shares significant homology with human b-Endorphin, making it a valuable model for research. Recent studies have explored its binding affinities, receptor interactions, and potential therapeutic applications, particularly in pain management and neuropsychiatric disorders.

CAS 59887-17-1, a chemical compound of interest, has been investigated for its potential to modulate the activity of b-Endorphin (sheep). Preliminary in vitro studies suggest that this compound may enhance the stability and bioavailability of b-Endorphin, thereby prolonging its therapeutic effects. Researchers have employed advanced techniques such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy to characterize the interaction between these molecules.

One notable study published in the Journal of Chemical Biology demonstrated that CAS 59887-17-1 forms a stable complex with b-Endorphin (sheep), potentially protecting it from enzymatic degradation. This finding opens new avenues for the development of long-acting b-Endorphin-based therapeutics. Additionally, molecular dynamics simulations have provided insights into the conformational changes induced by this interaction, further elucidating the mechanistic basis of its effects.

Despite these promising results, challenges remain in translating these findings into clinical applications. Issues such as delivery methods, dosage optimization, and potential side effects need to be addressed. Future research directions may include in vivo studies to assess the efficacy and safety of CAS 59887-17-1 in combination with b-Endorphin (sheep), as well as the exploration of synthetic analogs with improved pharmacokinetic properties.

In conclusion, the interplay between b-Endorphin (sheep) and CAS 59887-17-1 represents a promising area of research with significant therapeutic potential. Continued investigation into their molecular interactions and biological effects will be crucial for advancing our understanding and application of these compounds in medicine.

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