• 1. An assessment of strategies for the development of solid-state adsorbents for vehicular hydrogen storage
  Mark D. Allendorf,Alauddin Ahmed,Tom Autrey,Jeffrey Camp,Eun Seon Cho,Maciej Haranczyk,Abhi Karkamkar,Di-Jia Liu,Katie R. Meihaus,Iffat H. Nayyar,Roman Nazarov,Donald J. Siegel,Vitalie Stavila,Jeffrey J. Urban,Srimukh Prasad Veccham,Brandon C. Wood Energy Environ. Sci., 2018,11, 2784-2812
• 2. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 3. An intramolecular tryptophan-condensation approach for peptide stapling?
  Eunice Y.-L. Hui,Bhimsen Rout,Yaw Sing Tan,Kok-Ping Chan,Charles W. Johannes Org. Biomol. Chem., 2018,16, 389-392
• 4. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 5. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzamides
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzamides

Comprehensive Overview of N-tert-Butylbenzamide (CAS No. 5894-65-5): Properties, Applications, and Industry Insights

N-tert-Butylbenzamide (CAS No. 5894-65-5) is a specialized organic compound widely recognized for its role in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. This tertiary amide derivative, characterized by its benzamide core and tert-butyl substituent, exhibits unique physicochemical properties that make it valuable across multiple industries. With growing interest in high-performance amides and custom synthesis, this compound has garnered attention for its versatility and potential in green chemistry applications.

The molecular structure of N-tert-Butylbenzamide combines a benzene ring with a carboxamide functional group, modified by a bulky tert-butyl moiety. This configuration influences its solubility profile (moderate in polar solvents like ethanol but low in water) and thermal stability (decomposition typically above 200°C). Recent studies highlight its utility as a building block in peptide mimetics and small-molecule drug discovery, particularly in modulating bioavailability and metabolic resistance—key concerns in modern pharmaceutical R&D.

In agrochemical applications, 5894-65-5 serves as a precursor for crop protection agents, where its lipophilic nature enhances systemic activity in plants. Industry trends show rising demand for low-toxicity intermediates, positioning this compound as an alternative to traditional aromatic amides in sustainable pesticide formulations. Researchers are also exploring its potential in polymer additives, where it may improve UV resistance and thermal aging properties—a hot topic in material science forums.

Analytical characterization of N-tert-Butylbenzamide typically involves HPLC purity testing (≥98% purity for industrial use), FTIR spectroscopy (notable C=O stretch at ~1650 cm?1), and mass spectrometry (MW 191.27 g/mol). Quality control protocols emphasize the absence of residual solvents, a critical parameter for GMP-compliant production. Recent patents disclose novel catalytic amidation methods to synthesize this compound with improved atom economy, aligning with circular chemistry principles.

Market intelligence reveals increasing searches for "N-tert-Butylbenzamide suppliers," "5894-65-5 technical data sheet," and "benzamide derivatives applications," reflecting commercial interest. Environmental considerations drive innovation in waste minimization during synthesis, while QSAR modeling studies explore structure-activity relationships for bioactive analogs. As regulatory landscapes evolve, particularly in REACH compliance, proper SDS documentation for this compound remains essential for global trade.

Future prospects for CAS 5894-65-5 include emerging applications in electronic materials (as a dielectric layer modifier) and cosmetic stabilizers. The compound's low ecotoxicity profile makes it attractive for biodegradable formulations, addressing consumer demand for eco-friendly chemicals. Ongoing research investigates its synergistic effects with ionic liquids for energy storage systems—an area gaining traction in battery technology discussions.

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