Cas no 58880-19-6 (Trichostatin A)

Trichostatin A (TSA) is a potent and selective histone deacetylase (HDAC) inhibitor, widely utilized in epigenetic research. It exhibits high specificity for Class I and II HDACs, effectively inducing histone hyperacetylation and modulating gene expression. TSA is particularly valued for its ability to alter chromatin structure, making it a critical tool in studying cellular differentiation, apoptosis, and transcriptional regulation. Its reversible inhibition mechanism and well-characterized biochemical activity ensure reliable experimental reproducibility. Additionally, TSA is soluble in organic solvents like DMSO and ethanol, facilitating its use in cell culture and in vitro assays. Its consistent performance and broad applicability in oncology and neurology research underscore its significance in scientific investigations.
Trichostatin A structure
Trichostatin A structure
Product Name:Trichostatin A
CAS No:58880-19-6
MF:C17H22N2O3
MW:302.368184566498
MDL:MFCD03848392
CID:90005
PubChem ID:87560260
Update Time:2025-06-07

Trichostatin A Chemical and Physical Properties

Names and Identifiers

    • trichostatin A
    • Trichostatin A, Streptomyces sp.
    • (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
    • Trichostatin A (TSA)
    • TRICHOSTATIN A FROM STREPTOMYCES SP
    • TSA
    • [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    • (R)-Trichostatin A
    • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    • Trichostatin
    • Tricostatin A
    • RTKIYFITIVXBLE-QEQCGCAPSA-N
    • 3X2S926L3Z
    • 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    • 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-
    • 7-[4-(DIMETHYLAMINO)PHENYL]-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE
    • [R-(E,E)]-7-[
    • 3f0r
    • NSC-311042
    • NCGC00162453-04
    • 1c3r
    • 2,4-Heptadienamide,7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
    • C17H22N2O3
    • LMPK01000055
    • NCGC00162453-02
    • (2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide
    • Q425894
    • SR-05000013796
    • BRD-K68202742-001-05-8
    • SCHEMBL19886
    • Trichostatina
    • NS00034030
    • HMS3649O20
    • EX-A1665
    • BRD-K68202742-001-04-1
    • HB1402
    • HMS1792L09
    • NCGC00162453-01
    • AKOS015899840
    • T2477
    • BDBM50005711
    • M02571
    • 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, [R-(E,E)]-
    • AC-35470
    • SMR004702883
    • 2,4-HEPTADIENAMIDE, 7-(4-(DIMETHYLAMINO)PHENYL)-N-HYDROXY-4,6-DIMETHYL-7-OXO-,(2E,4E,6R)-
    • Trichostatin A, >=98% (HPLC), from Streptomyces sp.
    • (2E,4E,6R)-7-(4-dimethylaminophenyl)-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid
    • UNII-3X2S926L3Z
    • Antibiotic A-300
    • Trichostatin-A
    • s1045
    • (2E,4E,6R)-7-(4-(Dimethylamino)phen yl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamid e
    • GTPL7005
    • HY-15144
    • (R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
    • 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
    • CHEBI:93196
    • Trichostatin(s)
    • PD119680
    • trichostatine a
    • BCP01776
    • CCG-208142
    • BCPP000035
    • Trichostatin A from Streptomyces sp.
    • SW219664-1
    • 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)-
    • Trichlostatin A
    • SGCTO-002
    • CHEBI:46024
    • MLS006011095
    • 58880-19-6 (R-isomer)
    • 7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
    • VTR-297
    • Trichostatin A,TSA
    • (2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
    • CS-0499
    • TRICHOSTATIN A [MI]
    • NCGC_TSA
    • AS-74315
    • Trichostatin A??, Vetec(TM) reagent grade, from Streptomyces sp., >=98%
    • MFCD03848392
    • HMS1990L09
    • A25618
    • 2,4-Heptadienamide, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI)
    • A-300-I
    • CCG-208681
    • GNF-PF-1011
    • TSN
    • Trichostatin A, Streptomyces sp. - CAS 58880-19-6
    • DB04297
    • SCHEMBL675951
    • Q-201864
    • NSC 311042
    • NCGC00162453-03
    • NCGC00162453-05
    • 58880-19-6
    • HMS1362L09
    • HMS3403L09
    • 3C10
    • DTXSID6037063
    • SR-05000013796-3
    • NCGC00162453-15
    • LS-14594
    • NSC709238
    • 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
    • 2, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-
    • CS-0021924
    • NSC311042
    • Hepta-2, 7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl- 7-oxo-, (2E,4E,6R)-
    • PD128664
    • CHEBI:91570
    • Trichostatin A (racemate)
    • 503610-77-3
    • SCHEMBL446806
    • BRD-A19037878-001-01-5
    • 2, 7-[4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-
    • AKOS030213149
    • 1208356-08-4
    • 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide
    • NSC-709238
    • (2E,4E)-7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide
    • CHEMBL26159
    • VTR297
    • BRD-K68202742-001-13-2
    • (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-, 2,4-heptadienamide; [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide; (R)-Trichostatin A; TSA;
    • Trichostatin A (TSA)?
    • BRD-K68202742-001-16-5
    • Trichostatin A
    • MDL： MFCD03848392
    • Inchi： 1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
    • InChI Key： RTKIYFITIVXBLE-QEQCGCAPSA-N
    • SMILES： O=C(C1C=CC(=CC=1)N(C)C)[C@H](C)/C=C(/C=C/C(NO)=O)\C

Computed Properties

  • Exact Mass: 302.16300
  • Monoisotopic Mass: 302.163
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 22
  • Rotatable Bond Count: 6
  • Complexity: 447
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 2
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 9
  • XLogP3: 2.7
  • Topological Polar Surface Area: 69.6

Experimental Properties

  • Color/Form: Not determined
  • Density: 1.139
  • Melting Point: 140-143 oC
  • Refractive Index: 136 ° (C=0.3, MeOH)
  • Solubility: ethanol: 1?mg/mL
  • PSA: 69.64000
  • LogP: 2.97020
  • Merck: 9649
  • Specific Rotation: D20.5 +62.8° ±1.1° (c = 1.007 in ethanol)
  • Sensitiveness: Sensitive to heat

Trichostatin A Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302-H312-H315-H317-H319-H332-H335
  • Warning Statement： P261-P280-P305 + P351 + P338
  • Hazardous Material transportation number：NONH for all modes of transport
  • WGK Germany：3
  • Hazard Category Code： 20/21/22-36/37/38-43
  • Safety Instruction： S26; S36
  • Regulatory Condition Code：Class Q (sugars, alkaloids, antibiotics, hormones)
  • RTECS：MI5215000
  • Hazardous Material Identification： Xn
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
  • Risk Phrases：R20/21/22

Trichostatin A Customs Data

  • HS CODE：2924299090
  • Customs Data：

    China Customs Code:

    2924299090

    Overview:

    2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Trichostatin A Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
T129665-50mg
Trichostatin A
 58880-19-6 ≥98%
50mg
 ￥7799.90 2023-08-31
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
T129665-5mg
Trichostatin A
 58880-19-6 ≥98%
5mg
 ￥1499.90 2023-08-31
SHANG HAI A LA DING SHENG HUA KE JI GU FEN Co., Ltd.
T129665-10mg
Trichostatin A
 58880-19-6 ≥98%
10mg
 ￥2399.90 2023-08-31
S e l l e c k ZHONG GUO
S1045-2mg
Trichostatin A (TSA)
 58880-19-6 99.94%
2mg
 ￥ 1613.43 2023-11-02
S e l l e c k ZHONG GUO
S1045-5mg
Trichostatin A (TSA)
 58880-19-6 99.94%
5mg
 ￥ 3030.3 2023-11-02
HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI
QT5211-1mg
Trichostatin A
 58880-19-6 ≥98%
1mg
 ￥720元 2023-09-15
HE FEI BO MEI SHENG WU KE JI YOU XIAN ZE REN GONG SI
QT5211-5mg
Trichostatin A
 58880-19-6 ≥98%
5mg
 ￥3000元 2023-09-15
TRC
B589545-1mg
trichostatin
 58880-19-6
1mg
 $ 105.00 2022-06-07
TRC
B589545-5mg
trichostatin
 58880-19-6
5mg
 $ 400.00 2022-06-07
TRC
B589545-10mg
trichostatin
 58880-19-6
10mg
 $ 740.00 2022-06-07

Trichostatin A Related Literature

Related Categories

58880-19-6 (Trichostatin A) Related Products

Recommended suppliers
Zouping Mingyuan Import and Export Trading Co., Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Zouping Mingyuan Import and Export Trading Co., Ltd
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Hangzhou TSurgeX Pharmaceutical Technology Co., Ltd.
Shanghai Joy Biotech Ltd
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Shanghai Joy Biotech Ltd
Wuhan Comings Biotechnology Co., Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Bulk
Wuhan Comings Biotechnology Co., Ltd.
Wuhan ChemNorm Biotech Co.,Ltd.
Gold Member
Audited Supplier Audited Supplier
CN Supplier
Reagent
Wuhan ChemNorm Biotech Co.,Ltd.