Production Method 1

10535-17-8

5888-51-7

93-51-6

59056-76-7

5888-52-8

874-41-9

494-99-5

2785-87-7

2785-89-9

91-16-7

93-15-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ;  6 h, 330 °C

Reference

Molybdenum carbide, supercritical ethanol and base: Keys for unlocking renewable BTEX from lignin

Lui, Matthew Y.; et al, Applied Catalysis, 2023, 325,

Production Method 2

94687-10-2

5888-51-7

93-51-6

59056-76-7

5888-52-8

874-41-9

494-99-5

2785-87-7

2785-89-9

91-16-7

93-15-2

Reaction Conditions

1.1 Reagents: Lithium borohydride Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Water ;  rt
2.1 Reagents: Sodium hydroxide Solvents: Ethanol ;  6 h, 330 °C

Reference

Molybdenum carbide, supercritical ethanol and base: Keys for unlocking renewable BTEX from lignin

Lui, Matthew Y.; et al, Applied Catalysis, 2023, 325,

Production Method 3

13078-21-2

120-14-9

5888-51-7

93-51-6

59056-76-7

5888-52-8

874-41-9

494-99-5

2785-87-7

2785-89-9

91-16-7

93-15-2

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  1 h, -78 °C; 10 min
1.2 Solvents: Tetrahydrofuran ;  30 min; 2 h
1.3 Reagents: Carbon dioxide
2.1 Reagents: Lithium borohydride Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; overnight, rt
2.2 Reagents: Water ;  rt
3.1 Reagents: Sodium hydroxide Solvents: Ethanol ;  6 h, 330 °C

Reference

Molybdenum carbide, supercritical ethanol and base: Keys for unlocking renewable BTEX from lignin

Lui, Matthew Y.; et al, Applied Catalysis, 2023, 325,

Production Method 4

90-05-1

105-36-2

5888-51-7

93-51-6

59056-76-7

5888-52-8

874-41-9

494-99-5

2785-87-7

2785-89-9

91-16-7

93-15-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  overnight, rt → reflux
2.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  1 h, -78 °C; 10 min
2.2 Solvents: Tetrahydrofuran ;  30 min; 2 h
2.3 Reagents: Carbon dioxide
3.1 Reagents: Lithium borohydride Solvents: Tetrahydrofuran ;  0 °C; 0 °C → rt; overnight, rt
3.2 Reagents: Water ;  rt
4.1 Reagents: Sodium hydroxide Solvents: Ethanol ;  6 h, 330 °C

Reference

Molybdenum carbide, supercritical ethanol and base: Keys for unlocking renewable BTEX from lignin

Lui, Matthew Y.; et al, Applied Catalysis, 2023, 325,

4-Ethyl-1,2-dimethoxybenzene Raw materials

• Guaiacol
• Ethyl 2-(2-methoxyphenoxy)acetate
• Ethyl bromoacetate
• Veratraldehyde
• 1-(3,4-Dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol
• Ethyl 3-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxyphenoxy)propanoate

4-Ethyl-1,2-dimethoxybenzene Preparation Products

• 2-Methoxy-4-methylphenol (93-51-6)
• Benzene, 4-butyl-1,2-dimethoxy- (59056-76-7)
• 1,2-Dimethoxy-4-propylbenzene (5888-52-8)
• 1-Ethyl-2,4-dimethylbenzene (874-41-9)
• 3,4-Dimethoxytoluene (494-99-5)
• 4-Ethyl-1,2-dimethoxybenzene (5888-51-7)
• 2-Methoxy-4-propylphenol (2785-87-7)
• 4-Ethylguaiacol (2785-89-9)
• Veratrole (91-16-7)
• Methyl Eugenol (93-15-2)

• 1. An aqueous ammonia sensor based on an inkjet-printed polyaniline nanoparticle-modified electrode
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• 2. Alternative mixtures to R-600a. Theoretical assessment and experimental energy evaluation of binary mixtures in a commercial cooler: Mélanges alternatifs au R-600a. évaluation théorique et évaluation énergétique expérimentale de mélanges binaires dans un refroidisseur commercial.
  DanielCalleja-Anta,DanielSánchez,LauraNebot-Andres,RamónCabello,RodrigoLlopis
• 3. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
  Haitao Li,Yu Pan,Zhizhi Wang,Shan Chen,Ruixin Guo,Jianqiu Chen RSC Adv., 2015,5, 100775-100782
• 4. An investigation into the origin of variations in photovoltaic performance using D–D–π–A and D–A–π–A triphenylimidazole dyes with a copper electrolyte?
  Govind Reddy Mol. Syst. Des. Eng., 2021,6, 779-789
• 5. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Methoxybenzenes Dimethoxybenzenes
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Chemical Profile of 4-Ethyl-1,2-dimethoxybenzene (CAS No. 5888-51-7)

4-Ethyl-1,2-dimethoxybenzene, identified by the Chemical Abstracts Service registry number CAS No. 5888-51-7, is a significant organic compound that has garnered attention in the field of pharmaceutical chemistry and material science due to its unique structural and functional properties. This aromatic heterocyclic compound features a benzene ring substituted with two methoxy groups and an ethyl group, which contribute to its distinct chemical reactivity and potential applications.

The molecular structure of 4-Ethyl-1,2-dimethoxybenzene consists of a phenolic core, which is a well-known scaffold in medicinal chemistry. The presence of the ethyl group at the para position relative to the methoxy groups enhances its solubility in organic solvents and influences its electronic properties, making it a valuable intermediate in synthesizing more complex molecules. This compound’s ability to participate in various chemical reactions, such as electrophilic aromatic substitution and nucleophilic addition, underscores its versatility in synthetic chemistry.

In recent years, 4-Ethyl-1,2-dimethoxybenzene has been explored for its potential role in drug development. Its structural motif is reminiscent of several bioactive natural products and pharmaceutical agents, suggesting that it could serve as a precursor or analog in designing new therapeutic compounds. For instance, researchers have investigated its derivatives as candidates for antimicrobial and anti-inflammatory applications. The methoxy groups provide sites for further functionalization, enabling the creation of molecules with tailored biological activities.

The compound’s relevance extends beyond pharmaceuticals into the realm of specialty chemicals and materials science. Its aromatic nature makes it a candidate for use in liquid crystals, organic electronics, and polymer additives. The dimethoxy substitution pattern enhances thermal stability and processability, which are critical factors in industrial applications. Additionally, 4-Ethyl-1,2-dimethoxybenzene has been studied for its photophysical properties, showing promise as a component in optoelectronic devices due to its ability to absorb and emit light efficiently.

Recent advancements in computational chemistry have further highlighted the importance of 4-Ethyl-1,2-dimethoxybenzene. Molecular modeling studies indicate that this compound can act as a ligand in metal-organic frameworks (MOFs), where it could facilitate the design of novel catalysts or sensors. The interactions between the methoxy groups and transition metals provide opportunities for tuning electronic and steric properties, which is essential for optimizing catalytic performance.

The synthesis of 4-Ethyl-1,2-dimethoxybenzene typically involves aromatic alkylation followed by methylation reactions. Modern synthetic methodologies have improved yields and purity levels, making it more accessible for industrial-scale production. Green chemistry approaches have also been applied to minimize waste and energy consumption during its synthesis. These innovations align with global efforts to promote sustainable chemical manufacturing practices.

In conclusion, 4-Ethyl-1,2-dimethoxybenzene (CAS No. 5888-51-7) is a multifaceted compound with broad applications across pharmaceuticals, materials science, and industrial chemistry. Its unique structural features offer opportunities for developing novel drugs, advanced materials, and efficient catalysts. As research continues to uncover new uses for this compound, its significance in modern chemistry is likely to grow further.

• 2380-78-1(Homovanillyl alcohol)
• 2785-88-8(5-Ethyl-2-methoxyphenol)
• 1158-27-6(Benzene,1,1'-methylenebis[3,4-dimethoxy-)
• 919355-96-7(Phenol, 2-methoxy-5-[(4-methylphenyl)methyl]-)
• 2785-87-7(2-Methoxy-4-propylphenol)
• 2785-89-9(4-Ethylguaiacol)
• 7417-21-2(2-(3,4-Dimethoxyphenyl)ethanol)
• 14059-92-8(4-ethyl-2,6-dimethoxyphenol)
• 62224-32-2(Phenol, 4-ethyl-2-(4-ethylphenoxy)-)
• 88563-55-7(Ethylium, 1-(3,4-dimethoxyphenyl)-)