• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 3. Excimer emission and magnetoluminescence of radical-based zinc(ii) complexes doped in host crystals?
  Shojiro Kimura,Tetsuro Kusamoto Chem. Commun., 2020,56, 11195-11198
• 4. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
  Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
• 5. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693

Introduction to 2-(2,4-Dichlorophenoxy)propanoyl chloride (CAS No. 58048-37-6)

2-(2,4-Dichlorophenoxy)propanoyl chloride, identified by the Chemical Abstracts Service Number (CAS No.) 58048-37-6, is a significant intermediate in the field of organic synthesis and pharmaceutical chemistry. This compound belongs to the class of phenoxypropionyl chlorides, which are widely recognized for their utility in the synthesis of various bioactive molecules. The presence of two chlorine atoms at the 2 and 4 positions of the phenyl ring enhances its reactivity, making it a valuable building block for further functionalization.

The structure of 2-(2,4-Dichlorophenoxy)propanoyl chloride consists of a propanoyl group linked to a phenoxy moiety, which is itself substituted with two chlorine atoms. This specific arrangement imparts unique chemical properties that make it particularly useful in the development of agrochemicals and pharmaceuticals. The reactivity of the compound is primarily governed by the presence of the acyl chloride functionality, which readily participates in nucleophilic acyl substitution reactions.

In recent years, there has been growing interest in the applications of 2-(2,4-Dichlorophenoxy)propanoyl chloride due to its role as a precursor in synthesizing various biologically active compounds. For instance, researchers have explored its utility in the preparation of herbicides and fungicides, where its structural features contribute to enhanced efficacy against target organisms. The dichlorophenoxyl group is particularly notable for its ability to interact with biological targets, thereby influencing the activity of derived compounds.

One of the most compelling aspects of 2-(2,4-Dichlorophenoxy)propanoyl chloride is its versatility in synthetic chemistry. The acyl chloride group can be readily transformed into esters, amides, and other derivatives through standard reactions, allowing chemists to tailor the properties of their final products. This flexibility has made it a preferred choice for medicinal chemists working on drug discovery programs. Additionally, the compound's stability under various reaction conditions further enhances its appeal as an intermediate.

Recent advancements in synthetic methodologies have also highlighted the importance of 2-(2,4-Dichlorophenoxy)propanoyl chloride in modern chemical research. For example, studies have demonstrated its use in cross-coupling reactions, where it serves as an effective electrophile. These reactions are crucial for constructing complex molecular architectures and have found applications in both academic and industrial settings. The ability to incorporate this compound into diverse synthetic pathways underscores its significance in organic chemistry.

The pharmaceutical industry has particularly benefited from the use of 2-(2,4-Dichlorophenoxy)propanoyl chloride as a key intermediate. Researchers have leveraged its reactivity to develop novel therapeutic agents targeting various diseases. For instance, derivatives of this compound have been investigated for their potential antimicrobial and anti-inflammatory properties. The dichlorophenoxyl moiety plays a critical role in modulating biological activity, making it a valuable scaffold for drug design.

In conclusion, 2-(2,4-Dichlorophenoxy)propanoyl chloride (CAS No. 58048-37-6) is a versatile and highly reactive compound with broad applications in synthetic chemistry and pharmaceutical research. Its unique structural features and reactivity make it an indispensable tool for chemists working on agrochemicals and drug development. As research continues to uncover new synthetic possibilities and biological applications, the importance of this compound is expected to grow further.

• 64855-76-1(Propanoyl chloride, 2-[4-(2,4-dichlorophenoxy)phenoxy]-)
• 61994-01-2(Butanoyl chloride, 2-(2,3,4-trichlorophenoxy)-)
• 62047-39-6(Propanoyl chloride, 2-(2,3,5-trichlorophenoxy)-)
• 62047-38-5(Propanoyl chloride, 2-(3,4,5-trichlorophenoxy)-)
• 139554-53-3(Propanoyl chloride, 2-(2,4,6-trichlorophenoxy)-)
• 1160257-84-0(2-(2,5-Dichlorophenoxy)-2-methylpropanoyl chloride)
• 61993-99-5(Butanoyl chloride, 2-(2,3,5-trichlorophenoxy)-)
• 55746-49-1(Propanoyl chloride, 2-(2,4,5-trichlorophenoxy)-)
• 68534-29-2(Propanoyl chloride, 2-[2-chloro-5-(2,4-dichlorophenoxy)phenoxy]-)
• 211184-89-3(2-(2-Chloro-phenoxy)-propionyl Chloride)