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  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Biphenyls and derivatives Chlorinated biphenyls

Comprehensive Overview of 3-Chloro-4-phenylbenzaldehyde (CAS No. 57592-44-6): Properties, Applications, and Industry Insights

3-Chloro-4-phenylbenzaldehyde (CAS No. 57592-44-6) is a specialized organic compound widely recognized for its versatile applications in pharmaceuticals, agrochemicals, and material science. This aromatic aldehyde features a chloro substituent at the 3-position and a phenyl group at the 4-position of the benzaldehyde ring, imparting unique reactivity and functional properties. Its molecular structure (C₁₃H₉ClO) and high purity make it a critical intermediate in synthetic chemistry, particularly in the development of fine chemicals and advanced materials.

In recent years, the demand for 3-Chloro-4-phenylbenzaldehyde has surged due to its role in synthesizing pharmaceutical intermediates and bioactive molecules. Researchers highlight its utility in constructing heterocyclic compounds, which are pivotal in drug discovery for treating metabolic disorders and inflammatory diseases. The compound’s electron-withdrawing chloro group enhances its reactivity in cross-coupling reactions, a topic frequently searched in AI-driven chemistry platforms like Reaxys or SciFinder.

From an industrial perspective, CAS No. 57592-44-6 is manufactured under stringent GMP-compliant conditions to ensure consistency for high-value applications. Environmental and regulatory trends have also influenced its production, with a shift toward green chemistry protocols to minimize waste. This aligns with the growing search queries around “sustainable synthesis of aromatic aldehydes” and “eco-friendly halogenated compounds” in academic and industrial forums.

The compound’s physical properties—such as a melting point range of 85–88°C and solubility in organic solvents like ethanol and dichloromethane—are frequently cited in technical datasheets. These characteristics make it suitable for multistep organic synthesis, a key focus area for researchers optimizing catalytic processes. Notably, its stability under inert atmospheres has been explored in peer-reviewed studies, addressing common user questions about “handling sensitive aldehydes in air-sensitive reactions.”

Emerging applications of 3-Chloro-4-phenylbenzaldehyde include its use in OLED materials and liquid crystals, where its planar structure contributes to desirable optoelectronic properties. This connects to trending searches on “aromatic aldehydes in material science” and “small-molecule semiconductors.” Additionally, its derivatives are investigated for antimicrobial coatings, reflecting the broader interest in functionalized benzaldehydes for industrial hygiene solutions.

Quality control of CAS No. 57592-44-6 involves advanced analytical techniques like HPLC and GC-MS, ensuring compliance with international standards such as ISO and USP. Suppliers often emphasize batch-to-batch consistency, a critical factor for buyers searching for “reliable sources of halogenated benzaldehydes.” Storage recommendations typically include cool, dry conditions away from light, as degradation studies indicate sensitivity to prolonged UV exposure.

In summary, 3-Chloro-4-phenylbenzaldehyde (CAS No. 57592-44-6) represents a intersection of innovation and practicality in modern chemistry. Its adaptability across diverse sectors—from medicinal chemistry to advanced materials—ensures its relevance in both academic research and industrial applications. As synthetic methodologies evolve, this compound is poised to remain a staple in laboratories addressing global challenges in health and technology.

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