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  Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
• 2. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 3. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 4. An approach to the structure and vibrational analysis of cis- and trans-3-chlorostyrene through IR/Raman and INS spectroscopies and theoretical ab initio/DFT calculations?
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• 5. An insight into the role of side chains in the microstructure and carrier mobility of high-performance conjugated polymers?
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Comprehensive Guide to 1-Ethyl-3-methyl-1H-pyrazole hydrochloride (CAS No. 57241-76-6): Properties, Applications, and Market Insights

1-Ethyl-3-methyl-1H-pyrazole hydrochloride (CAS No. 57241-76-6) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This heterocyclic compound, belonging to the pyrazole derivatives family, exhibits unique chemical properties that make it valuable for various industrial applications. With the increasing demand for nitrogen-containing heterocycles in drug discovery, this compound has become a subject of intense scientific investigation.

The molecular structure of 1-Ethyl-3-methyl-1H-pyrazole hydrochloride features a five-membered aromatic ring containing two nitrogen atoms at adjacent positions. This structural characteristic contributes to its remarkable stability and reactivity, making it an excellent building block for more complex molecules. Researchers particularly value its hydrogen chloride salt form, which enhances solubility and handling properties in synthetic applications.

In pharmaceutical applications, 1-Ethyl-3-methyl-1H-pyrazole hydrochloride serves as a crucial intermediate in the synthesis of various bioactive molecules. Recent studies have explored its potential in developing anti-inflammatory agents and CNS-active compounds, aligning with current trends in neurological disorder research. The compound's versatility also extends to material science, where it contributes to the development of advanced functional materials with specific electronic properties.

The synthesis of 1-Ethyl-3-methyl-1H-pyrazole hydrochloride typically involves condensation reactions between appropriate hydrazine derivatives and β-diketones, followed by salt formation. Modern synthetic approaches emphasize green chemistry principles, reflecting the growing industry focus on sustainable production methods. Process optimization has led to improved yields and purity levels exceeding 98%, meeting the stringent requirements of pharmaceutical applications.

From a commercial perspective, the global market for pyrazole derivatives like 1-Ethyl-3-methyl-1H-pyrazole hydrochloride has shown steady growth, driven by expanding applications in medicinal chemistry. Leading suppliers have reported increased demand, particularly from research institutions and specialty chemical manufacturers. The compound's cost-effectiveness compared to similar heterocyclic building blocks contributes to its competitive advantage in the fine chemicals market.

Quality control protocols for 1-Ethyl-3-methyl-1H-pyrazole hydrochloride typically involve advanced analytical techniques including HPLC, NMR spectroscopy, and mass spectrometry. These methods ensure compliance with international purity standards and verify the absence of process-related impurities. Storage recommendations emphasize protection from moisture and maintenance at controlled room temperature to preserve the compound's stability over extended periods.

Recent patent literature reveals growing intellectual property activity surrounding 1-Ethyl-3-methyl-1H-pyrazole hydrochloride derivatives, particularly in therapeutic applications. This trend reflects the compound's potential in addressing current healthcare challenges, including the development of novel antiviral agents and enzyme inhibitors. The scientific community continues to explore structure-activity relationships to optimize its pharmacological properties.

Environmental and safety considerations for handling 1-Ethyl-3-methyl-1H-pyrazole hydrochloride follow standard laboratory protocols for organic salts. While not classified as hazardous under normal conditions, proper personal protective equipment including gloves and safety glasses is recommended during manipulation. The compound's environmental impact is considered minimal when disposed of according to established chemical waste management procedures.

Future research directions for 1-Ethyl-3-methyl-1H-pyrazole hydrochloride include exploration of its coordination chemistry with transition metals and potential applications in catalysis. The compound's structural features suggest possible utility in designing new ligand systems for asymmetric synthesis, an area of significant interest in modern organic chemistry. These developments could further expand its industrial relevance beyond current applications.

For researchers seeking high-quality 1-Ethyl-3-methyl-1H-pyrazole hydrochloride, several specialty chemical suppliers offer the compound in various quantities, from milligram-scale for initial screening to kilogram quantities for process development. Technical specifications typically include detailed certificates of analysis and comprehensive safety data sheets to support research and development activities across multiple disciplines.

The versatility of 1-Ethyl-3-methyl-1H-pyrazole hydrochloride (CAS No. 57241-76-6) ensures its continued importance in chemical research and industrial applications. As synthetic methodologies advance and new biological targets emerge, this compound is poised to maintain its position as a valuable tool in the chemist's repertoire, contributing to innovations in medicine, materials science, and beyond.

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