• 1. Disulfide- and terminal alkyne-functionalized magnetic silica particles for enrichment of azido glycopeptides?
  Sheng Wang,Wenxian Xie,Xiu Zhang,Xia Zou,Yan Zhang Chem. Commun., 2012,48, 5907-5909
• 2. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 3. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 4. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 5. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130

4-Formyl-benzamidine: A Comprehensive Overview

4-Formyl-benzamidine, also known by its CAS number 55514-20-0, is a compound of significant interest in the fields of organic chemistry and materials science. This compound, characterized by its unique molecular structure, has garnered attention due to its potential applications in drug discovery, catalysis, and advanced materials. In this article, we delve into the properties, synthesis, and recent advancements in the research of 4-formyl-benzamidine, providing a comprehensive understanding of its significance in contemporary scientific studies.

The molecular structure of 4-formyl-benzamidine comprises a benzene ring substituted with a formyl group (-CHO) and a benzamidine moiety. The benzamidine group, which consists of an amine (-NH2) attached to a benzene ring via a methylene bridge (-CH2-), contributes to the compound's unique reactivity and stability. The presence of the formyl group introduces additional functionality, enabling participation in various chemical reactions such as condensation and oxidation processes. Recent studies have highlighted the role of 4-formyl-benzamidine in forming stable complexes with metal ions, making it a promising candidate for catalytic applications.

The synthesis of 4-formyl-benzamidine typically involves multi-step reactions, often starting from readily available aromatic compounds. One common approach involves the condensation of benzaldehyde with guanidine hydrochloride in the presence of an appropriate base. This method not only ensures high yield but also allows for precise control over the product's purity. Researchers have recently explored alternative synthetic pathways utilizing microwave-assisted synthesis and continuous flow reactors, which offer enhanced efficiency and scalability.

4-Formyl-benzamidine's chemical properties make it an attractive candidate for various applications. In drug discovery, its ability to act as a scaffold for bioactive molecules has been extensively studied. Recent findings suggest that derivatives of 4-formyl-benzamidine exhibit potent anti-inflammatory and anticancer activities, making them promising leads for therapeutic development. Additionally, the compound's role as a ligand in metalloenzyme mimics has opened new avenues in catalytic chemistry.

In terms of materials science, 4-formyl-benzamidine's ability to form self-assembled monolayers (SAMs) has been leveraged for creating advanced surfaces with tailored properties. These SAMs exhibit excellent stability under various environmental conditions and have been proposed for use in sensors and electronic devices. Recent advancements in computational modeling have provided deeper insights into the molecular interactions governing SAM formation, further enhancing their potential applications.

The study of 4-formyl-benzamidine's interaction with biological systems has also yielded fascinating results. Researchers have demonstrated that certain derivatives possess selective binding affinity towards specific proteins, making them valuable tools in proteomics and diagnostics. Furthermore, the compound's role as a chiral selector in asymmetric synthesis has been explored, offering new strategies for producing enantiomerically pure compounds—an essential requirement in pharmaceutical manufacturing.

In conclusion, 4-formyl-benzamidine, with its unique molecular architecture and versatile reactivity, continues to be a focal point in scientific research. Its applications span across multiple disciplines, from drug discovery to materials science, underscoring its importance as a multifaceted chemical entity. As ongoing studies uncover new facets of its potential, CAS No 55514-20-0-based compounds are poised to play an increasingly significant role in advancing modern science and technology.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)