• 1. An integrated chip for immunofluorescence and its application to analyze lysosomal storage disorders
  Jie Shen,Ying Zhou,Tu Lu,Junya Peng,Zhixiang Lin,Yuhong Pang,Li Yu Lab Chip, 2012,12, 317-324
• 2. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381
• 3. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 4. Alternative donor substrates for inverting and retaining glycosyltransferases?
  Luke L. Lairson,Warren W. Wakarchuk Chem. Commun., 2007, 365-367
• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219

Comprehensive Overview of 4-Chloropyrimidin-5-amine (CAS No. 54660-78-5): Properties, Applications, and Industry Insights

4-Chloropyrimidin-5-amine (CAS No. 54660-78-5) is a specialized heterocyclic compound that has garnered significant attention in pharmaceutical and agrochemical research. This chloropyrimidine derivative serves as a critical building block in synthetic chemistry due to its unique reactivity and structural versatility. With the molecular formula C₄H₄ClN₃, it features a pyrimidine ring substituted with chlorine and amine functional groups, enabling diverse chemical transformations.

The growing demand for pyrimidine-based intermediates in drug discovery aligns with trends in personalized medicine and targeted therapies. Researchers frequently search for "4-chloropyrimidin-5-amine synthesis" or "CAS 54660-78-5 applications," reflecting its relevance in developing kinase inhibitors and antiviral agents. Its role in covalent drug design—a hot topic in AI-driven drug development—has been explored in recent literature, particularly for modulating protein-ligand interactions.

From a technical perspective, 54660-78-5 exhibits notable stability under inert atmospheres but requires careful handling due to its sensitivity to moisture. Analytical methods like HPLC and LC-MS are commonly employed for purity verification (>98%), a key concern for buyers searching "high-purity 4-chloropyrimidin-5-amine suppliers." The compound's chlorine-amine synergy allows selective cross-coupling reactions, making it valuable for constructing N-heterocyclic scaffolds—a frequent subject in organic chemistry forums.

Environmental considerations have spurred interest in "green synthesis of chloropyrimidines," with recent patents describing solvent-free approaches for 4-chloropyrimidin-5-amine production. This aligns with the pharmaceutical industry's push toward sustainable chemistry. Additionally, its potential in crop protection chemicals has been investigated, though non-aggressive formulations dominate current research to meet ecological regulations.

The compound's crystallization behavior—often searched as "54660-78-5 polymorphs"—shows two distinct crystalline forms characterized by X-ray diffraction. This property is crucial for formulation scientists optimizing drug bioavailability. Recent computational studies using molecular docking simulations (a trending AI application) predict its binding affinity with biological targets, accelerating virtual screening workflows.

Supply chain dynamics reveal increasing global demand for 4-chloropyrimidin-5-amine, particularly from contract research organizations (CROs). Quality certifications like ISO 9001 and analytical documentation (COA) are frequently requested by purchasers, as evidenced by search terms such as "CAS 54660-78-5 specification sheet." The compound's shelf life under refrigerated conditions (2-8°C) remains a common technical inquiry among end-users.

Emerging applications include its use in photoaffinity labeling probes for proteomics research—a technique gaining traction in biomarker discovery. This positions 54660-78-5 at the intersection of chemical biology and diagnostic development. Furthermore, its derivatization into fluorescent tags for cellular imaging demonstrates cross-disciplinary utility beyond traditional medicinal chemistry.

Regulatory compliance remains paramount, with manufacturers emphasizing REACH registration and proper SDS documentation for 4-chloropyrimidin-5-amine. The absence of controlled substance classifications facilitates international trade, though stringent impurity profiling is recommended—addressing another frequent search concern: "54660-78-5 HPLC methods."

In conclusion, 4-chloropyrimidin-5-amine (CAS No. 54660-78-5) represents a multifaceted tool for modern chemical innovation. Its evolving applications across drug development, materials science, and biochemical tools underscore the importance of this chloropyrimidine building block in contemporary research landscapes.

• 55583-59-0(dichloropyrimidine-2,5-diamine)
• 5177-27-5(5-Amino-2,4-dichloropyrimidine)
• 5413-85-4(4,6-dichloropyrimidin-5-amine)
• 20090-59-9(4-Chloro-2-methylpyrimidin-5-amine)
• 6959-84-8(4,6-dichloro-N-methylpyrimidin-5-amine)
• 39906-04-2(4,6-Dichloro-2-methylpyrimidin-5-amine)
• 59447-72-2(4-Chloro-N-methylpyrimidin-5-amine)
• 56145-03-0(4,6-Dichloropyrimidine-2,5-diamine hydrochloride)
• 91322-00-8(2,4,6-Trichloropyrimidin-5-amine)
• 14631-09-5(2,5-Pyrimidinediamine,4-chloro-)