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  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Enabling high-throughput single-animal gene-expression studies with molecular and micro-scale technologies
  Jason Wan Lab Chip, 2020,20, 4528-4538
• 3. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Diarylethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Diarylethers

Comprehensive Overview of 2-(4-Fluorophenoxy)nicotinic acid (CAS No. 54629-13-9): Properties, Applications, and Industry Insights

2-(4-Fluorophenoxy)nicotinic acid (CAS No. 54629-13-9) is a specialized organic compound with a molecular formula of C₁₂H₈FNO₃. This compound belongs to the class of nicotinic acid derivatives, which are widely studied for their potential applications in pharmaceuticals, agrochemicals, and material science. The presence of both a fluorophenoxy group and a nicotinic acid moiety in its structure makes it a versatile intermediate for synthetic chemistry. Researchers and industry professionals often search for terms like "2-(4-Fluorophenoxy)nicotinic acid synthesis", "CAS 54629-13-9 applications", and "fluorophenoxy derivatives in drug discovery", reflecting its growing relevance in modern chemistry.

The compound's unique structure contributes to its physicochemical properties, including a moderate solubility in polar organic solvents and a melting point range of 160–165°C. Its fluorine-substituted aromatic ring enhances its stability and bioavailability, making it a candidate for medicinal chemistry applications. Recent trends in drug development highlight the demand for fluorinated building blocks, as they often improve metabolic stability and binding affinity. Searches for "fluorine in pharmaceuticals 2024" or "nicotinic acid derivatives in CNS drugs" align with the interest in this compound's potential.

In agrochemical research, 2-(4-Fluorophenoxy)nicotinic acid is explored as a precursor for herbicides and plant growth regulators. The fluorophenoxy group is known to influence the activity of auxin-like compounds, a topic frequently queried as "fluorophenoxy herbicides mechanism". Environmental concerns have also driven searches for "biodegradable fluorinated agrochemicals", positioning this compound as a subject of sustainable chemistry discussions.

From a synthetic perspective, the compound is typically prepared via Pd-catalyzed cross-coupling or nucleophilic aromatic substitution reactions, with researchers often searching for "optimized synthesis of nicotinic acid derivatives". Its purity (>98%) is critical for high-yield downstream applications, as reflected in queries like "HPLC analysis of fluorophenoxy compounds". Analytical techniques such as NMR, LC-MS, and FTIR are routinely employed for characterization.

The compound's safety profile is another hot topic, with searches for "54629-13-9 safety data sheet" and "fluorophenoxy compound toxicity studies". While not classified as hazardous under standard regulations, proper handling protocols are emphasized in industrial settings. This aligns with the broader trend of "green chemistry in fluorine compound synthesis", a highly searched term in 2024.

Market analysts note increasing demand for 2-(4-Fluorophenoxy)nicotinic acid in Asia-Pacific regions, particularly for pharmaceutical intermediates. Queries like "CAS 54629-13-9 suppliers China" and "fluorophenoxy compound price trends" reflect commercial interest. The compound's patent landscape is also dynamic, with searches for "nicotinic acid derivative patents 2024" indicating competitive R&D activity.

In material science, the compound's potential as a ligand for metal-organic frameworks (MOFs) has gained attention, coinciding with searches for "fluorinated MOF precursors". Its ability to coordinate with transition metals while maintaining thermal stability makes it valuable for gas storage applications, a subject trending under "advanced materials for carbon capture".

For researchers exploring structure-activity relationships (SAR), the compound serves as a model for studying "electronic effects of fluorine in heterocycles"—a frequently published topic. Computational chemistry searches like "DFT studies on fluorophenoxy compounds" further demonstrate its theoretical importance. The rise of AI-assisted drug discovery has also increased interest in such structurally diverse building blocks.

Quality control remains paramount, with industry standards requiring rigorous testing for residual solvents and heavy metals (searches for "ICH guidelines for fluorinated APIs"). The compound's shelf life and storage conditions (typically 2–8°C under inert atmosphere) are practical concerns reflected in queries like "long-term stability of nicotinic acid derivatives".

Emerging applications in PET radiopharmaceuticals have sparked searches for "fluorine-18 labeled nicotinic analogs", while its potential in ionic liquid synthesis connects to queries about "task-specific fluorinated ionic liquids". These diverse applications underscore why 2-(4-Fluorophenoxy)nicotinic acid remains a compound of significant interdisciplinary interest in 2024.

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