• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives

Introduction to 5,6-Dichloropyridine-3-carbonyl Chloride (CAS No. 54127-29-6)

5,6-Dichloropyridine-3-carbonyl chloride, also known by its CAS number 54127-29-6, is a versatile organic compound that has garnered significant attention in the fields of medicinal chemistry and chemical synthesis. This compound is characterized by its unique molecular structure, which includes a pyridine ring substituted with two chlorine atoms and a carbonyl chloride group. The combination of these functional groups endows the molecule with a range of chemical properties that make it a valuable reagent in various synthetic processes.

The chemical formula of 5,6-Dichloropyridine-3-carbonyl chloride is C₇H₃Cl₃N₁O₁. It is a colorless to pale yellow liquid with a molecular weight of approximately 208.00 g/mol. The compound is highly reactive due to the presence of the carbonyl chloride group, which readily undergoes nucleophilic acyl substitution reactions. This reactivity makes it an excellent building block for the synthesis of more complex molecules, particularly in the development of pharmaceuticals and agrochemicals.

In recent years, 5,6-Dichloropyridine-3-carbonyl chloride has been extensively studied for its potential applications in drug discovery and development. One notable area of research involves its use as an intermediate in the synthesis of pyridine-based drugs. Pyridine derivatives are known for their diverse biological activities, including anti-inflammatory, antiviral, and anticancer properties. For instance, a study published in the Journal of Medicinal Chemistry (2021) reported the successful synthesis of a series of pyridine-based compounds using 5,6-Dichloropyridine-3-carbonyl chloride as a key intermediate. These compounds exhibited potent antitumor activity against various cancer cell lines, highlighting the potential of this reagent in the development of novel therapeutic agents.

Beyond its use in medicinal chemistry, 5,6-Dichloropyridine-3-carbonyl chloride has also found applications in the synthesis of agrochemicals. Pyridine derivatives are widely used as herbicides and insecticides due to their ability to disrupt key biological processes in plants and insects. A recent study in the Pest Management Science (2022) demonstrated the effectiveness of a new class of pyridine-based herbicides synthesized using 5,6-Dichloropyridine-3-carbonyl chloride. These herbicides showed high selectivity and low toxicity to non-target organisms, making them promising candidates for sustainable agricultural practices.

The synthesis of 5,6-Dichloropyridine-3-carbonyl chloride typically involves multi-step processes that require careful control of reaction conditions to ensure high yields and purity. One common synthetic route involves the chlorination of 5,6-dichloropyridin-3-amine followed by conversion to the corresponding acid chloride. Advances in green chemistry have led to the development of more environmentally friendly methods for synthesizing this compound. For example, a study published in the

The safety and handling of 5,6-Dichloropyridine-3-carbonyl chloride are critical considerations for researchers and industrial chemists. The compound is highly reactive and can release toxic fumes when exposed to moisture or heat. Therefore, it should be stored in tightly sealed containers under inert conditions and handled with appropriate personal protective equipment (PPE). Additionally, proper disposal methods should be followed to prevent environmental contamination.

In conclusion, 5,6-Dichloropyridine-3-carbonyl chloride (CAS No. 54127-29-6) is a valuable reagent with diverse applications in medicinal chemistry and chemical synthesis. Its unique molecular structure and reactivity make it an essential building block for the development of novel drugs and agrochemicals. Ongoing research continues to uncover new possibilities for this compound, further solidifying its importance in the scientific community.

• 49609-84-9(2-Chloronicotinoyl chloride)
• 607351-40-6(3-Pyridinecarbonyl chloride, 2,4-dichloro-)
• 71690-05-6(5,6-Dichloropyridyl-3-carboxaldehyde)
• 176433-64-0(3-Pyridinecarbonylchloride, 6-chloro-5-formyl-)
• 78686-87-0(2,5-Dichloropyridine-3-carbonyl Chloride)
• 66608-11-5(6-chloropyridine-3-carbonyl chloride hydrochloride)
• 85320-79-2(3-Pyridinecarbonyl chloride, 5-chloro-)
• 58757-38-3(6-CHLORONICOTINOYL CHLORIDE)
• 176433-51-5(3-Pyridinecarbonylchloride, 2-chloro-5-formyl-)
• 54127-31-0(2,3-Dichloro-5-(chloromethyl)pyridine)