Cas no 54053-45-1 ((R)-2-Chlorobutyric Acid)

(R)-2-Chlorobutyric Acid is a chiral carboxylic acid derivative with the molecular formula C?H?ClO?. It serves as a valuable intermediate in organic synthesis, particularly in the production of enantiomerically pure pharmaceuticals, agrochemicals, and specialty chemicals. The compound's stereospecificity enables precise control over reaction pathways, making it advantageous for asymmetric synthesis. Its chlorine substituent enhances reactivity in nucleophilic substitution and elimination reactions. (R)-2-Chlorobutyric Acid is typically used under controlled conditions due to its corrosive nature. High-purity grades are available to meet stringent application requirements in research and industrial processes. Proper handling and storage are essential to maintain stability and prevent degradation.
(R)-2-Chlorobutyric Acid structure
(R)-2-Chlorobutyric Acid structure
Product Name:(R)-2-Chlorobutyric Acid
CAS No:54053-45-1
MF:C4H7ClO2
MW:122.550180673599
MDL:MFCD00067098
CID:367341
PubChem ID:5326288
Update Time:2025-11-07

(R)-2-Chlorobutyric Acid Chemical and Physical Properties

Names and Identifiers

    • Butanoic acid,2-chloro-, (2R)-
    • (R)-2-chlorobutanoic acid
    • (R)-2-Chlorobutyric Acid
    • (R)-(+)-2-CHLOROBUTANOIC ACID
    • (+)-alpha-Chlorobutanoic acid
    • (R)-alpha-Chlorobutyric acid
    • (2R)-2-chlorobutanoic acid
    • (R)-2-Chlorbuttersaure
    • Butanoic acid, 2-chloro-, (2R)-
    • A7861
    • 54053-45-1
    • (R)-2-ChlorobutyricAcid
    • AKOS015848429
    • BS-43995
    • AKOS006378193
    • SCHEMBL605192
    • TQP0742
    • T71033
    • (R)-2-chlorobutanoicacid
    • MFCD00067098
    • (R)-(+)-2-CHLOROBUTANOICACID
    • EN300-222189
    • C2109
    • MDL： MFCD00067098
    • Inchi： 1S/C4H7ClO2/c1-2-3(5)4(6)7/h3H,2H2,1H3,(H,6,7)/t3-/m1/s1
    • InChI Key： RVBUZBPJAGZHSQ-GSVOUGTGSA-N
    • SMILES： Cl[C@@H](C(=O)O)CC

Computed Properties

  • Exact Mass: 122.01300
  • Monoisotopic Mass: 122.013
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 7
  • Rotatable Bond Count: 2
  • Complexity: 72.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 1.3
  • Topological Polar Surface Area: 37.3

Experimental Properties

  • Color/Form: Not determined
  • Density: 1.213±0.06 g/cm3 (20 oC 760 Torr),
  • Melting Point: Not available
  • Boiling Point: 98°C/14mmHg(lit.)
  • Flash Point: 76.7±19.8 oC,
  • Refractive Index: 17 ° (C=neat)
  • Solubility: Slightly soluble (26 g/l) (25 o C),
  • PSA: 37.30000
  • LogP: 1.08840
  • Solubility: Not determined
  • Vapor Pressure: 0.1±0.8 mmHg at 25°C

(R)-2-Chlorobutyric Acid Security Information

(R)-2-Chlorobutyric Acid Customs Data

  • HS CODE：2915900090
  • Customs Data：

    China Customs Code:

    2915900090

    Overview:

    2915900090. Other saturated acyclic monocarboxylic acids and their anhydrides(Acyl halide\Peroxygenation)Chemicals\Peroxy acid and its halogenation\nitrification\sulfonation\Nitrosative derivative. VAT:17.0%. Tax refund rate:9.0%. Regulatory conditions:AB(Customs clearance form for Inbound Goods,Customs clearance form for outbound goods). MFN tariff:5.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Regulatory conditions:

    A.Customs clearance form for Inbound Goods
    B.Customs clearance form for outbound goods

    Inspection and quarantine category:

    R.Sanitary supervision and inspection of imported food
    S.Sanitary supervision and inspection of exported food
    M.Import commodity inspection
    N.Export commodity inspection

    Summary:

    2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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(R)-2-Chlorobutyric Acid Suppliers

Amadis Chemical Company Limited
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(CAS:54053-45-1)(R)-2-Chlorobutyric Acid
Order Number:A7861
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Monday, 2 September 2024 16:04
Price ($):304.0

(R)-2-Chlorobutyric Acid Related Literature

Additional information on (R)-2-Chlorobutyric Acid

Recent Advances in the Application of (R)-2-Chlorobutyric Acid (CAS: 54053-45-1) in Chemical Biology and Pharmaceutical Research

(R)-2-Chlorobutyric Acid (CAS: 54053-45-1) is a chiral carboxylic acid derivative that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound serves as a key intermediate in the synthesis of various bioactive molecules and has been extensively studied for its potential in drug development. Recent studies have highlighted its role in the synthesis of enantiomerically pure compounds, which are crucial for the development of targeted therapies with reduced side effects.

One of the most notable advancements in the use of (R)-2-Chlorobutyric Acid is its incorporation into the synthesis of novel chiral ligands and catalysts. Researchers have demonstrated that this compound can be used to create highly efficient catalysts for asymmetric synthesis, enabling the production of complex molecules with high enantioselectivity. For instance, a 2023 study published in the Journal of Medicinal Chemistry reported the successful use of (R)-2-Chlorobutyric Acid-derived catalysts in the synthesis of beta-amino acids, which are important building blocks for peptidomimetic drugs.

In addition to its role in catalysis, (R)-2-Chlorobutyric Acid has been explored as a precursor for the development of new antimicrobial agents. A recent study in the European Journal of Medicinal Chemistry (2024) revealed that derivatives of (R)-2-Chlorobutyric Acid exhibit potent activity against multidrug-resistant bacterial strains. The study identified specific structural modifications that enhance the compound's antibacterial properties while minimizing toxicity, paving the way for the development of next-generation antibiotics.

Another promising application of (R)-2-Chlorobutyric Acid is in the field of cancer research. Researchers have utilized this compound to synthesize novel histone deacetylase (HDAC) inhibitors, which are a class of drugs that have shown potential in treating various cancers. A 2024 study in Bioorganic & Medicinal Chemistry Letters demonstrated that (R)-2-Chlorobutyric Acid-based HDAC inhibitors exhibit selective cytotoxicity against cancer cells, with minimal effects on normal cells. This selectivity is attributed to the chiral nature of the compound, which allows for precise interactions with biological targets.

Despite these advancements, challenges remain in the large-scale production and application of (R)-2-Chlorobutyric Acid. Recent research has focused on optimizing synthetic routes to improve yield and reduce costs. For example, a 2023 study in Organic Process Research & Development described a novel enzymatic resolution method that significantly enhances the efficiency of (R)-2-Chlorobutyric Acid production. This method not only improves yield but also aligns with the growing demand for sustainable and environmentally friendly synthetic processes.

In conclusion, (R)-2-Chlorobutyric Acid (CAS: 54053-45-1) continues to be a valuable tool in chemical biology and pharmaceutical research. Its applications in asymmetric synthesis, antimicrobial development, and cancer therapy underscore its versatility and potential for future innovations. Ongoing research efforts are expected to further expand its utility and address current limitations, making it a compound of enduring interest in the scientific community.

54053-45-1 ((R)-2-Chlorobutyric Acid) Related Products

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Amadis Chemical Company Limited
(CAS:54053-45-1)(R)-2-Chlorobutyric Acid
A7861
Purity:99%
Quantity:5g
Price ($):304.0
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