• 1. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
  Craig A. Kelly,David R. Rosseinsky Phys. Chem. Chem. Phys., 2001,3, 2086-2090
• 2. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 3. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 4. Evolution of dealloying induced strain in nanoporous gold crystals?
  Ross Harder,David C. Dunand,Ian McNulty Nanoscale, 2017,9, 5686-5693
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

Introduction to 3-Methylthio-2-butanone (CAS No. 53475-15-3)

3-Methylthio-2-butanone, identified by the Chemical Abstracts Service Number (CAS No.) 53475-15-3, is a significant organic compound that has garnered attention in the field of chemical biology and pharmaceutical research. This compound, characterized by its unique molecular structure, exhibits a range of potential applications that span from synthetic chemistry to drug development. Its molecular formula, C₅H₁₂OS, underscores its role as a sulfur-containing heterocyclic compound, which is increasingly relevant in modern medicinal chemistry due to its structural versatility and biological activity.

The structure of 3-Methylthio-2-butanone consists of a ketone group (C=O) attached to a methylthio (-SCH₃) substituent on a butanone backbone. This configuration imparts distinct chemical properties that make it a valuable intermediate in organic synthesis. The presence of the sulfur atom not only influences its reactivity but also enhances its potential as a bioactive molecule. In recent years, the study of sulfur-containing compounds has seen substantial growth, driven by their role in modulating biological pathways and their incorporation into pharmacophores that exhibit therapeutic effects.

In the realm of chemical biology, 3-Methylthio-2-butanone has been explored for its potential role as a modulator of enzyme activity and signal transduction pathways. Research indicates that sulfur-containing compounds often interact with biological targets in unique ways, making them promising candidates for drug discovery. Specifically, the methylthio group in 3-Methylthio-2-butanone can participate in hydrogen bonding and hydrophobic interactions, which are critical for binding to biological macromolecules such as proteins and enzymes. This property has led to investigations into its potential use as an inhibitor or activator in various biochemical processes.

Recent studies have highlighted the pharmaceutical applications of 3-Methylthio-2-butanone and related derivatives. For instance, researchers have examined its efficacy in inhibiting specific enzymes implicated in inflammatory responses and metabolic disorders. The compound’s ability to mimic or interfere with natural signaling molecules makes it an attractive scaffold for designing novel therapeutic agents. Additionally, its stability under various reaction conditions enhances its utility as a synthetic intermediate in the preparation of more complex molecules.

The synthetic chemistry of 3-Methylthio-2-butanone is another area where this compound has demonstrated significant utility. Its synthesis typically involves reactions such as thiolation of ketones or condensation reactions involving sulfur-containing precursors. These synthetic pathways are not only efficient but also scalable, making 3-Methylthio-2-butanone accessible for industrial applications. Furthermore, the compound’s reactivity allows for further functionalization, enabling the creation of libraries of derivatives with tailored properties for specific applications.

In conclusion, 3-Methylthio-2-butanone (CAS No. 53475-15-3) is a versatile and intriguing compound with broad implications in chemical biology and pharmaceutical research. Its unique structural features and biological activity make it a valuable asset in both academic research and industrial applications. As the field of medicinal chemistry continues to evolve, compounds like 3-Methylthio-2-butanone are poised to play an increasingly important role in the discovery and development of new therapeutic agents that address unmet medical needs.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)