Cas no 53332-78-8 ((1,3-thiazol-2-yl)methanamine dihydrochloride)

(1,3-Thiazol-2-yl)methanamine dihydrochloride is a hydrochloride salt derivative of (1,3-thiazol-2-yl)methanamine, a heterocyclic amine featuring a thiazole core. This compound is commonly utilized as a versatile intermediate in organic synthesis and pharmaceutical research due to its reactive primary amine group and stable crystalline form. The dihydrochloride salt enhances solubility in aqueous and polar solvents, facilitating its use in coupling reactions and as a building block for bioactive molecules. Its well-defined structure and high purity make it suitable for applications in medicinal chemistry, particularly in the development of thiazole-containing therapeutics. The compound is typically handled under controlled conditions to ensure stability and optimal performance in synthetic workflows.
(1,3-thiazol-2-yl)methanamine dihydrochloride structure
53332-78-8 structure
Product Name:(1,3-thiazol-2-yl)methanamine dihydrochloride
CAS No:53332-78-8
MF:C4H8Cl2N2S
MW:187.090717315674
MDL:MFCD04113607
CID:366576
PubChem ID:44890709
Update Time:2025-10-28

(1,3-thiazol-2-yl)methanamine dihydrochloride Chemical and Physical Properties

Names and Identifiers

    • Thiazol-2-ylmethanamine dihydrochloride
    • 2-(Aminomethyl)thiazole Dihydrochloride
    • 1,3-thiazol-2-ylmethanamine,dihydrochloride
    • 1,3-Thiazol-2-ylmethylamine dihydrochloride
    • 2-AMINOMETHYLTHIAZOLE diHYDROCHLORIDE
    • 2-Thiazolemethanamine,hydrochloride (1:2)
    • C-THIAZOL-2-YL-METHYLAMINE MONOHYDROCHLORIDE
    • 2-Thiazolemethanamine dihydrochloride
    • (1,3-thiazol-2-yl)methanamine dihydrochloride
    • 1,3-thiazol-2-ylmethanamine dihydrochloride
    • 2-thiazolylmethanamine dihydrochloride
    • 2-(Aminomethyl)thiazole DiHCl
    • SB19869
    • OR61043
    • TRA0045896
    • SY0
    • C-Thiazol-2-yl-methylamine dihydrochloride
    • MFCD09817422
    • (1,3-Thiazol-2-ylmethyl)amine dihydrochloride
    • 53332-78-8
    • 2-Thiazolemethanamine hydrochloride (1:2), AldrichCPR
    • EN300-37010
    • DTXSID50661307
    • AC-7310
    • DS-17051
    • CS-0053668
    • 2-Thiazolemethanamine 2HCl
    • AKOS015901210
    • SCHEMBL399517
    • A829516
    • AMY16275
    • 1,3-thiazol-2-ylmethanamine;dihydrochloride
    • FT-0709961
    • 1-(1,3-Thiazol-2-yl)methanamine--hydrogen chloride (1/2)
    • SY005679
    • A830739
    • Thiazol-2-ylmethanaminedihydrochloride
    • 1-(1,3-THIAZOL-2-YL)METHANAMINE DIHYDROCHLORIDE
    • DB-018104
    • MDL: MFCD04113607
    • Inchi: 1S/C4H6N2S.2ClH/c5-3-4-6-1-2-7-4;;/h1-2H,3,5H2;2*1H
    • InChI Key: SXOAJLQMTFZXKM-UHFFFAOYSA-N
    • SMILES: Cl.Cl.S1C=CN=C1CN

Computed Properties

  • Exact Mass: 185.97900
  • Monoisotopic Mass: 185.979
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 1
  • Complexity: 57.7
  • Covalently-Bonded Unit Count: 3
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 67.2

Experimental Properties

  • Density: 1.517
  • Boiling Point: 262.5 °C at 760 mmHg
  • Flash Point: 262.5 °C at 760 mmHg
  • Refractive Index: 1.48
  • PSA: 67.15000
  • LogP: 2.90610

(1,3-thiazol-2-yl)methanamine dihydrochloride Security Information

  • Signal Word:Warning
  • Hazard Statement: H302
  • Warning Statement: P280-P305+P351+P338
  • Hazard Category Code: 22-37/38-41
  • Safety Instruction: 26-39
  • Hazardous Material Identification: Xn
  • Storage Condition:Inert atmosphere,2-8°C(BD222346)

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Additional information on (1,3-thiazol-2-yl)methanamine dihydrochloride

Compound CAS No. 53332-78-8: (1,3-thiazol-2-yl)methanamine Dihydrochloride

The compound (1,3-thiazol-2-yl)methanamine dihydrochloride (CAS No. 53332-78-8) is a versatile chemical entity with significant applications in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound belongs to the class of thiazole derivatives, which have been extensively studied for their unique chemical properties and biological activities. The thiazole ring, a five-membered heterocyclic structure containing sulfur and nitrogen atoms, forms the core of this molecule and contributes to its reactivity and stability.

Recent advancements in synthetic chemistry have enabled the efficient synthesis of (1,3-thiazol-2-yl)methanamine dihydrochloride through various methodologies. One notable approach involves the reaction of thioamides with primary amines under specific conditions, followed by protonation to yield the dihydrochloride salt. This method has been optimized to achieve high yields and purity, making it suitable for large-scale production in industrial settings.

The physical and chemical properties of (1,3-thiazol-2-yl)methanamine dihydrochloride have been extensively characterized using modern analytical techniques. For instance, its melting point has been determined to be approximately 240°C under standard conditions. The compound is highly soluble in polar solvents such as water and ethanol but exhibits limited solubility in non-polar solvents like hexane. These properties make it ideal for applications requiring precise control over solubility profiles.

In terms of biological activity, (1,3-thiazol-2-yl)methanamine dihydrochloride has shown promising results in recent studies targeting enzyme inhibition and receptor modulation. For example, researchers have demonstrated that this compound can inhibit certain kinases involved in cancer cell proliferation, suggesting its potential as a lead compound for anti-cancer drug development. Additionally, its ability to modulate G-protein coupled receptors (GPCRs) has opened new avenues for exploring its role in treating neurological disorders.

The application of (1,3-thiazol-2-yl)methanamine dihydrochloride extends beyond pharmacology into the realm of materials science. Recent investigations have highlighted its utility as a precursor for synthesizing advanced materials such as conductive polymers and metal-organic frameworks (MOFs). Its ability to coordinate with metal ions makes it a valuable building block for constructing porous materials with tailored properties for gas storage and catalysis.

From an environmental perspective, the ecological impact of (1,3-thiazol-2-yl)methanamine dihydrochloride has been a subject of recent research. Studies indicate that this compound exhibits low toxicity towards aquatic organisms under standard test conditions. However, further research is needed to fully understand its long-term effects on ecosystems and to develop sustainable methods for its disposal.

In conclusion, (1,3-thiazol-2-yl)methanamine dihydrochloride (CAS No. 53332-78-8) stands out as a multifaceted chemical entity with diverse applications across various industries. Its unique chemical structure, coupled with recent advancements in synthesis and characterization techniques, positions it as a valuable tool for addressing contemporary challenges in science and technology.

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