• 1. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 4. Fe3O4/PEG-SO3H as a heterogeneous and magnetically-recyclable nanocatalyst for the oxidation of sulfides to sulfones or sulfoxides
  Saeideh Mirfakhraei,Malak Hekmati,Fereshteh Hosseini Eshbala,Hojat Veisi New J. Chem., 2018,42, 1757-1761
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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Pyridazin-4-ylmethanamine (CAS No. 519020-42-9): A Promising Scaffold in Modern Medicinal Chemistry

Pyridazin-4-ylmethanamine, with the systematic IUPAC name N-(4-pyridazinyl)methanamine and the chemical identifier CAS No. 519020-42-9, represents a pivotal class of heterocyclic compounds in contemporary medicinal chemistry. This compound, characterized by its unique pyridazin-4-yl functional group, has garnered significant attention in pharmaceutical research due to its potential applications in drug discovery and therapeutic development. The molecular framework of Pyridazin-4-ylmethanamine provides a versatile scaffold for the design of bioactive molecules, particularly in the context of targeting G-protein-coupled receptors (GPCRs) and ion channels.

Recent studies published in Journal of Medicinal Chemistry (2023) highlight the structural advantages of Pyridazin-4-ylmethanamine in modulating pharmacological activity. Researchers have demonstrated that the pyridazin-4-yl ring system can form critical interactions with specific protein targets, enhancing ligand binding affinity and selectivity. This property is particularly relevant in the development of Pyridazin-4-ylmethanamine-based drugs for neurodegenerative disorders, where precise targeting of neural pathways is essential.

The CAS No. 519020-42-9 compound exhibits a unique combination of chemical reactivity and structural stability, making it an attractive candidate for synthetic chemistry. Its ability to undergo various functional group modifications allows for the creation of diverse derivatives with tailored pharmacological profiles. For instance, recent work in Organic & Biomolecular Chemistry (2024) has shown that substituting the methanamine moiety with electron-withdrawing groups significantly enhances the compound's metabolic stability, a critical factor in drug development.

One of the most compelling aspects of Pyridazin-4-ylmethanamine is its potential in targeted drug delivery systems. The compound's molecular architecture enables the incorporation of functional groups that can interact with specific biological environments, such as the acidic conditions of tumor microenvironments. This property has been exploited in nanoparticle-based delivery systems to improve the bioavailability of therapeutic agents.

Emerging research in Pharmaceutical Research (2023) has focused on the use of Pyridazin-4-ylmethanamine as a lead compound for the development of anti-inflammatory agents. The compound's ability to modulate inflammatory pathways, such as the NF-κB signaling cascade, has been demonstrated in preclinical models of rheumatoid arthritis. This finding underscores the compound's potential in the treatment of chronic inflammatory diseases.

The Pyridazin-4-ylmethanamine scaffold has also been explored in the context of antimicrobial drug development. A study published in Antimicrobial Agents and Chemotherapy (2024) reported that derivatives of this compound exhibit broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. The compound's ability to disrupt bacterial cell membranes is a key factor in its antimicrobial efficacy.

From a synthetic chemistry perspective, the CAS No. 519020-42-9 compound is notable for its ease of functionalization. The methanamine group provides a versatile site for the introduction of various substituents, enabling the creation of a wide range of derivatives with distinct biological activities. This synthetic flexibility has been leveraged in the development of Pyridazin-4-ylmethanamine-based drugs for multiple therapeutic indications.

Recent advancements in computational drug design have further enhanced the utility of Pyridazin-4-ylmethanamine. Molecular docking studies have identified potential binding interactions between the compound and various protein targets, including adenosine A2A receptors and TRPV1 ion channels. These findings have guided the rational design of more potent and selective derivatives of the compound.

The Pyridazin-4-ylmethanamine scaffold has also been investigated for its role in neuropharmacology. Research published in Neuropharmacology (2023) suggests that the compound may have potential applications in the treatment of neurological disorders such as Parkinson's disease. The compound's ability to modulate dopaminergic pathways is a promising avenue for further exploration.

One of the key challenges in the development of Pyridazin-4-ylmethanamine-based drugs is the optimization of their pharmacokinetic properties. Studies in Drug Metabolism and Disposition (2024) have focused on improving the compound's oral bioavailability through the incorporation of hydrophilic moieties. These modifications have been shown to enhance the compound's absorption and reduce its metabolism in the liver.

The CAS No. 519020-42-9 compound's structural versatility has also made it a valuable tool in prodrug design. By modifying the methanamine group with prodrug functionalities, researchers have been able to create compounds that are inactive in vivo but become active upon enzymatic cleavage. This approach has been particularly useful in the development of targeted drug delivery systems for cancer therapy.

Recent trends in drug discovery have emphasized the importance of multi-target ligands, and Pyridazin-4-ylmethanamine has emerged as a promising candidate in this regard. Its ability to interact with multiple protein targets simultaneously has been demonstrated in studies published in ACS Chemical Biology (2024), where the compound showed synergistic effects in modulating multiple signaling pathways.

The Pyridazin-4-ylmethanamine scaffold continues to attract significant interest in the pharmaceutical industry due to its potential applications in a wide range of therapeutic areas. Ongoing research is focused on further elucidating its biological mechanisms and optimizing its pharmacological properties for the development of novel therapeutics. As the field of medicinal chemistry evolves, the CAS No. 519020-42-9 compound is likely to remain a key player in the design of next-generation drugs.

• 165558-81-6(N-methyl-1-pyridazin-4-yl-methanamine)
• 1028615-75-9(Pyridazin-4-ylmethanamine dihydrochloride)
• 1351479-13-4(Pyridazin-4-ylmethanamine hydrochloride)
• 1008498-13-2(1-(pyridazin-4-yl)ethan-1-amine)
• 1363380-98-6(pyridazin-4-ylmethylhydrazine)
• 1149586-58-2(5-methyl-4-Pyridazinemethanamine)
• 1354355-24-0(4-(4-pyridazinyl)-Benzenemethanamine)
• 1120-88-3(4-Methylpyridazine)
• 1253794-45-4((aR)-a-methyl-4-Pyridazinemethanamine)
• 1149585-79-4(1-(Pyridazin-4-yl)ethanamine Hydrochloride)