Cas no 1028615-75-9 (Pyridazin-4-ylmethanamine dihydrochloride)

Pyridazin-4-ylmethanamine dihydrochloride is a dihydrochloride salt derivative of pyridazin-4-ylmethanamine, commonly utilized as a versatile intermediate in organic synthesis and pharmaceutical research. Its stable crystalline form and high solubility in aqueous solutions enhance its utility in reaction schemes requiring precise amine functionalization. The compound’s pyridazine core offers a rigid heterocyclic scaffold, facilitating the development of bioactive molecules, particularly in medicinal chemistry for targeting enzyme inhibition or receptor modulation. The dihydrochloride salt form improves handling and storage stability compared to the free base. This reagent is valued for its consistent purity and reliability in synthetic applications, making it a practical choice for researchers in drug discovery and development.
Pyridazin-4-ylmethanamine dihydrochloride structure
1028615-75-9 structure
Product Name:Pyridazin-4-ylmethanamine dihydrochloride
CAS No:1028615-75-9
MF:C5H9Cl2N3
MW:182.051058530807
MDL:MFCD27756609
CID:838808
PubChem ID:67024095
Update Time:2025-11-02

Pyridazin-4-ylmethanamine dihydrochloride Chemical and Physical Properties

Names and Identifiers

    • Pyridazin-4-ylmethanamine dihydrochloride
    • 4-AMinoMethylpyridazine dihydrochloride
    • 4-PyridazineMethanaMine hydrochloride
    • 4-Pyridazinemethanamine dihydrochloride
    • (pyridazin-4-ylmethyl)amine dihydrochloride
    • ZTHDCITZMPPPKQ-UHFFFAOYSA-N
    • (pyridazin-4-ylmethyl)amine 2hcl
    • SB10016
    • Pyridazin-4-ylmethylamine dihydrochloride
    • AX8220455
    • 1028615-75-9
    • EN300-1604979
    • MFCD27756609
    • (pyridazin-4-yl)methanamine dihydrochloride
    • AS-33384
    • SY097971
    • Pyridazin-4-ylmethanaminedihydrochloride
    • AKOS022182771
    • CS-0048736
    • 4-Pyridazinylmethanamine Dihydrochloride
    • SCHEMBL1416120
    • pyridazin-4-ylmethanamine;dihydrochloride
    • MDL: MFCD27756609
    • Inchi: 1S/C5H7N3.2ClH/c6-3-5-1-2-7-8-4-5;;/h1-2,4H,3,6H2;2*1H
    • InChI Key: ZTHDCITZMPPPKQ-UHFFFAOYSA-N
    • SMILES: Cl.Cl.NCC1=CN=NC=C1

Computed Properties

  • Exact Mass: 181.0173527g/mol
  • Monoisotopic Mass: 181.0173527g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 64.7
  • Covalently-Bonded Unit Count: 3
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 51.8

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Additional information on Pyridazin-4-ylmethanamine dihydrochloride

Exploring Pyridazin-4-ylmethanamine Dihydrochloride (CAS No. 1028615-75-9): Properties, Applications, and Market Insights

Pyridazin-4-ylmethanamine dihydrochloride (CAS No. 1028615-75-9) is a specialized organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, characterized by its pyridazine core and amine hydrochloride functionality, serves as a versatile building block in drug discovery and development. With the increasing demand for novel heterocyclic compounds in medicinal chemistry, Pyridazin-4-ylmethanamine dihydrochloride stands out due to its unique structural features and potential therapeutic applications.

The molecular structure of Pyridazin-4-ylmethanamine dihydrochloride includes a pyridazine ring, a six-membered aromatic heterocycle containing two nitrogen atoms, which is known for its electron-deficient nature. This property makes it an excellent scaffold for designing enzyme inhibitors and receptor modulators. The dihydrochloride salt form enhances the compound's solubility in aqueous solutions, a critical factor for bioavailability in drug formulations. Researchers are particularly interested in its role as an intermediate in synthesizing central nervous system (CNS) targeting molecules, given the rising global focus on neurological disorders.

One of the most searched questions about Pyridazin-4-ylmethanamine dihydrochloride relates to its applications in drug discovery. Recent studies highlight its utility in developing kinase inhibitors, a hot topic in oncology research. Kinases play a pivotal role in cell signaling pathways, and their dysregulation is linked to various cancers. The pyridazine moiety in this compound can interact with ATP-binding sites of kinases, making it a promising candidate for anticancer drug development. Additionally, its potential in designing neuroprotective agents aligns with the growing interest in neurodegenerative diseases like Alzheimer's and Parkinson's.

The synthesis and purification of Pyridazin-4-ylmethanamine dihydrochloride (CAS No. 1028615-75-9) involve multi-step organic reactions, often starting from pyridazine derivatives. Advanced techniques such as high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy are employed to ensure high purity and structural confirmation. These methods are frequently searched by chemists and researchers working with heterocyclic compounds, reflecting the compound's relevance in modern synthetic chemistry.

Market trends indicate a steady increase in the demand for Pyridazin-4-ylmethanamine dihydrochloride, driven by its applications in pharmaceutical intermediates and biochemical research. The compound is often listed by suppliers specializing in fine chemicals and custom synthesis, catering to academic institutions and pharmaceutical companies. With the rise of AI-driven drug discovery, there is a surge in queries about how such compounds integrate into computational modeling and virtual screening workflows, further boosting its visibility in scientific databases.

Safety and handling of Pyridazin-4-ylmethanamine dihydrochloride are also common topics of interest. While it is not classified as a hazardous material, standard laboratory precautions, such as wearing personal protective equipment (PPE) and working in a well-ventilated area, are recommended. Researchers often search for material safety data sheets (MSDS) to ensure compliance with safety protocols, emphasizing the importance of transparency in chemical handling.

In conclusion, Pyridazin-4-ylmethanamine dihydrochloride (CAS No. 1028615-75-9) is a compound of significant scientific and commercial value. Its structural uniqueness, coupled with its applications in drug discovery and biochemical research, positions it as a key player in the evolving landscape of medicinal chemistry. As the pharmaceutical industry continues to explore heterocyclic scaffolds for novel therapies, this compound is likely to remain a focal point of research and development efforts worldwide.

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